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Ddx60 DExD/H box helicase 60 [ Mus musculus (house mouse) ]

Gene ID: 234311, updated on 23-Jun-2021

Summary

Official Symbol
Ddx60provided by MGI
Official Full Name
DExD/H box helicase 60provided by MGI
Primary source
MGI:MGI:2384570
See related
Ensembl:ENSMUSG00000037921
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9830118M07
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Ddx60 in Genome Data Viewer
Location:
8; 8 B3.1
Exon count:
40
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (62381121..62490735)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (61928073..62037704)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (64406886..64516492)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene palladin, cytoskeletal associated protein Neighboring gene lysyl-tRNA synthetase pseudogene Neighboring gene RIKEN cDNA 4930512H18 gene Neighboring gene annexin A10 Neighboring gene predicted gene 2961

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC19297

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables single-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within defense response to virus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of MDA-5 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of RIG-I signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in response to virus ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
probable ATP-dependent RNA helicase DDX60
Names
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
NP_001280712.1
XP_006509456.1
XP_006509459.1
XP_011240516.1
XP_017168186.1
XP_017168187.1
XP_036009806.1
XP_036009807.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001293783.1NP_001280712.1  probable ATP-dependent RNA helicase DDX60

    See identical proteins and their annotated locations for NP_001280712.1

    Status: VALIDATED

    Source sequence(s)
    AC139846, AC144858
    Consensus CDS
    CCDS52556.2
    UniProtKB/TrEMBL
    G3X9F7
    Related
    ENSMUSP00000070741.8, ENSMUST00000070631.15
    Conserved Domains (3) summary
    smart00490
    Location:12521328
    HELICc; helicase superfamily c-terminal domain
    smart00487
    Location:760951
    DEXDc; DEAD-like helicases superfamily
    pfam00270
    Location:766920
    DEAD; DEAD/DEAH box helicase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    62381121..62490735
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509393.3XP_006509456.1  probable ATP-dependent RNA helicase DDX60 isoform X1

    Conserved Domains (2) summary
    COG4581
    Location:6081318
    Dob10; Superfamily II RNA helicase [Replication, recombination and repair]
    cd18025
    Location:713885
    DEXHc_DDX60; DEXH-box helicase domain of DEAD box protein 60
  2. XM_017312697.3XP_017168186.1  probable ATP-dependent RNA helicase DDX60 isoform X5

    Conserved Domains (1) summary
    cd18025
    Location:761938
    DEXHc_DDX60; DEXH-box helicase domain of DEAD box protein 60
  3. XM_006509396.3XP_006509459.1  probable ATP-dependent RNA helicase DDX60 isoform X6

    Conserved Domains (1) summary
    cd18025
    Location:761938
    DEXHc_DDX60; DEXH-box helicase domain of DEAD box protein 60
  4. XM_011242214.3XP_011240516.1  probable ATP-dependent RNA helicase DDX60 isoform X3

    Conserved Domains (1) summary
    cd18025
    Location:761938
    DEXHc_DDX60; DEXH-box helicase domain of DEAD box protein 60
  5. XM_036153914.1XP_036009807.1  probable ATP-dependent RNA helicase DDX60 isoform X4

    Conserved Domains (1) summary
    cd18025
    Location:761938
    DEXHc_DDX60; DEXH-box helicase domain of DEAD box protein 60
  6. XM_017312698.3XP_017168187.1  probable ATP-dependent RNA helicase DDX60 isoform X7

    Conserved Domains (1) summary
    cl28899
    Location:761858
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
  7. XM_036153913.1XP_036009806.1  probable ATP-dependent RNA helicase DDX60 isoform X2

    Conserved Domains (2) summary
    COG4581
    Location:356967
    Dob10; Superfamily II RNA helicase [Replication, recombination and repair]
    cd18025
    Location:357534
    DEXHc_DDX60; DEXH-box helicase domain of DEAD box protein 60

RNA

  1. XR_001778429.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001081215.1: Suppressed sequence

    Description
    NM_001081215.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  2. NM_144928.1: Suppressed sequence

    Description
    NM_144928.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
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