Psd3 pleckstrin and Sec7 domain containing 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Psd3provided by MGI
Official Full Name: pleckstrin and Sec7 domain containing 3provided by MGI
Primary source: MGI:MGI:1918215
See related: Ensembl:ENSMUSG00000030465 AllianceGenome:MGI:1918215
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: EFA6D; D430018P08; 4931420C21Rik
Summary: Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of ARF protein signal transduction. Predicted to act upstream of or within ARF protein signal transduction. Located in ruffle membrane. Is expressed in several structures, including brain; eye; genitourinary system; hemolymphoid system gland; and liver. Orthologous to human PSD3 (pleckstrin and Sec7 domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in cortex adult (RPKM 13.0), frontal lobe adult (RPKM 12.7) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 B3.2- B3.3; 8 33.46 cM

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (68141728..68664740, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (67689082..68212063, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PSD3 downregulation confers protection against fatty liver disease.
Title: PSD3 downregulation confers protection against fatty liver disease.
Genetic variants of EFA6D were found to be distributed in overlapping patterns throughout the subcellular brain.
Title: Distinct subcellular localization of alternative splicing variants of EFA6D, a guanine nucleotide exchange factor for Arf6, in the mouse brain.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI661273 (e-PCR)
- UniSTS:164378

D8Mit340 (e-PCR), detects polymorphism
- UniSTS:131554

Psd3 (e-PCR), detects polymorphism
- UniSTS:496626

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within ARF protein signal transduction	IC Inferred by Curator more info	PubMed
involved_in regulation of ARF protein signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
NOT located_in cleavage furrow	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in ruffle membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in ruffle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: PH and SEC7 domain-containing protein 3

Names: exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 D; exchange factor for ARF6 D; guanine nucleotide exchange factor for ADP ribosylation factor 6; pleckstrin homology and SEC7 domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001419758.1 → NP_001406687.1 PH and SEC7 domain-containing protein 3 isoform 4

Status: VALIDATED

Source sequence(s)

AC109142, AC122500, AC125262
NM_001419759.1 → NP_001406688.1 PH and SEC7 domain-containing protein 3 isoform 5

Status: VALIDATED

Source sequence(s)

AC109142, AC122500, AC125262
NM_001419760.1 → NP_001406689.1 PH and SEC7 domain-containing protein 3 isoform 6

Status: VALIDATED

Source sequence(s)

AC109142, AC122500
NM_001419761.1 → NP_001406690.1 PH and SEC7 domain-containing protein 3 isoform 7

Status: VALIDATED

Source sequence(s)

AC109142, AC122500
NM_001419762.1 → NP_001406691.1 PH and SEC7 domain-containing protein 3 isoform 8

Status: VALIDATED

Source sequence(s)

AC109142, AC122500
NM_001419763.1 → NP_001406692.1 PH and SEC7 domain-containing protein 3 isoform 9

Status: VALIDATED

Source sequence(s)

AC109142, AC122500
NM_027626.2 → NP_081902.1 PH and SEC7 domain-containing protein 3 isoform 3

Status: VALIDATED

Source sequence(s)

AC109142, AC122500

Consensus CDS

CCDS52563.1

UniProtKB/TrEMBL

E9PUC5

Related

ENSMUSP00000112545.2, ENSMUST00000120071.8

Conserved Domains (2) summary

cd13295
Location:109 → 234

PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain

pfam00169
Location:114 → 222

PH; PH domain
NM_030263.6 → NP_084539.2 PH and SEC7 domain-containing protein 3 isoform 1

See identical proteins and their annotated locations for NP_084539.2

Status: VALIDATED

Source sequence(s)

AC109142, AC122500

Consensus CDS

CCDS22340.1

UniProtKB/Swiss-Prot

Q2PFD7

UniProtKB/TrEMBL

Q78V97

Related

ENSMUSP00000091178.6, ENSMUST00000093468.12

Conserved Domains (3) summary

cd00171
Location:52 → 206

Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...

cd13295
Location:251 → 376

PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain

pfam00169
Location:256 → 364

PH; PH domain
NM_177698.6 → NP_808366.2 PH and SEC7 domain-containing protein 3 isoform 2

See identical proteins and their annotated locations for NP_808366.2

Status: VALIDATED

Source sequence(s)

AC109142, AC122500, AC125262

Consensus CDS

CCDS40355.3

UniProtKB/TrEMBL

F6Z9E6

Related

ENSMUSP00000091179.5, ENSMUST00000093469.11

Conserved Domains (3) summary

cd00171
Location:537 → 692

Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...

cd13295
Location:737 → 862

PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain

pfam00169
Location:742 → 850

PH; PH domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

68141728..68664740 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036153921.1 → XP_036009814.1 PH and SEC7 domain-containing protein 3 isoform X3

UniProtKB/TrEMBL

A0A1D5RMH7

Related

ENSMUSP00000148783.2, ENSMUST00000212960.2

Conserved Domains (2) summary

cd00171
Location:823 → 977

Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...

cd13295
Location:1022 → 1147

PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain
XM_036153919.1 → XP_036009812.1 PH and SEC7 domain-containing protein 3 isoform X1

Conserved Domains (2) summary

cd00171
Location:823 → 977

Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...

cd13295
Location:1022 → 1147

PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain
XM_036153918.1 → XP_036009811.1 PH and SEC7 domain-containing protein 3 isoform X1

Conserved Domains (2) summary

cd00171
Location:823 → 977

Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...

cd13295
Location:1022 → 1147

PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain
XM_036153920.1 → XP_036009813.1 PH and SEC7 domain-containing protein 3 isoform X2

Conserved Domains (2) summary

cd00171
Location:822 → 976

Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...

cd13295
Location:1021 → 1146

PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain
XM_036153917.1 → XP_036009810.1 PH and SEC7 domain-containing protein 3 isoform X1

Conserved Domains (2) summary

cd00171
Location:823 → 977

Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...

cd13295
Location:1022 → 1147

PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain
XM_036153923.1 → XP_036009816.1 PH and SEC7 domain-containing protein 3 isoform X5

UniProtKB/TrEMBL

A0A1D5RLK2

Conserved Domains (2) summary

cd00171
Location:569 → 723

Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...

cd13295
Location:768 → 893

PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain
XM_036153922.1 → XP_036009815.1 PH and SEC7 domain-containing protein 3 isoform X4

UniProtKB/Swiss-Prot

Q2PFD7, Q3TTA1, Q80TN6, Q80UZ7, Q8CEA6

Conserved Domains (2) summary

cd00171
Location:570 → 724

Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...

cd13295
Location:769 → 894

PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain
XM_036153927.1 → XP_036009820.1 PH and SEC7 domain-containing protein 3 isoform X10

UniProtKB/TrEMBL

F6Z9E6

Conserved Domains (2) summary

cd00171
Location:505 → 659

Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...

cd13295
Location:704 → 829

PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain
XM_036153925.1 → XP_036009818.1 PH and SEC7 domain-containing protein 3 isoform X8

UniProtKB/TrEMBL

F6Z9E6

Conserved Domains (2) summary

cd00171
Location:536 → 690

Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...

cd13295
Location:735 → 860

PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain
XM_036153924.1 → XP_036009817.1 PH and SEC7 domain-containing protein 3 isoform X7

UniProtKB/TrEMBL

F6Z9E6

Conserved Domains (2) summary

cd00171
Location:537 → 691

Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...

cd13295
Location:736 → 861

PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain
XM_036153928.1 → XP_036009821.1 PH and SEC7 domain-containing protein 3 isoform X10

UniProtKB/TrEMBL

F6Z9E6

Conserved Domains (2) summary

cd00171
Location:505 → 659

Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...

cd13295
Location:704 → 829

PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain
XM_036153931.1 → XP_036009824.1 PH and SEC7 domain-containing protein 3 isoform X21

Conserved Domains (2) summary

cd00171
Location:52 → 206

Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...

cd13295
Location:251 → 376

PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain
XM_017312704.3 → XP_017168193.1 PH and SEC7 domain-containing protein 3 isoform X9

Conserved Domains (1) summary

cd00171
Location:823 → 967

Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
XM_017312705.3 → XP_017168194.1 PH and SEC7 domain-containing protein 3 isoform X11

Conserved Domains (1) summary

cd00171
Location:823 → 966

Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
XM_036153929.1 → XP_036009822.1 PH and SEC7 domain-containing protein 3 isoform X12

Conserved Domains (1) summary

cd00171
Location:823 → 968

Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
XM_017312707.3 → XP_017168196.1 PH and SEC7 domain-containing protein 3 isoform X18

Conserved Domains (2) summary

COG5307
Location:701 → 879

COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]

cl00136
Location:823 → 879

Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
XM_011242288.4 → XP_011240590.1 PH and SEC7 domain-containing protein 3 isoform X13

Conserved Domains (2) summary

COG5307
Location:701 → 934

COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]

cd00171
Location:823 → 936

Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
XM_036153930.1 → XP_036009823.1 PH and SEC7 domain-containing protein 3 isoform X19

Conserved Domains (2) summary

COG5307
Location:701 → 879

COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]

cl00136
Location:823 → 879

Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
XM_006509619.5 → XP_006509682.1 PH and SEC7 domain-containing protein 3 isoform X14

Conserved Domains (2) summary

COG5307
Location:701 → 934

COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]

cd00171
Location:823 → 936

Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
XM_017312706.3 → XP_017168195.1 PH and SEC7 domain-containing protein 3 isoform X17

Conserved Domains (2) summary

COG5307
Location:701 → 879

COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]

cl00136
Location:823 → 879

Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
XM_006509620.5 → XP_006509683.1 PH and SEC7 domain-containing protein 3 isoform X15

Conserved Domains (2) summary

COG5307
Location:701 → 934

COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]

cd00171
Location:823 → 936

Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
XM_017312709.3 → XP_017168198.1 PH and SEC7 domain-containing protein 3 isoform X20

Conserved Domains (2) summary

COG5307
Location:701 → 879

COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]

cl00136
Location:823 → 879

Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
XM_006509621.5 → XP_006509684.1 PH and SEC7 domain-containing protein 3 isoform X16

Conserved Domains (2) summary

COG5307
Location:701 → 934

COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]

cd00171
Location:823 → 938

Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...