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Inpp4b inositol polyphosphate-4-phosphatase, type II [ Mus musculus (house mouse) ]

Gene ID: 234515, updated on 21-Apr-2024

Summary

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Official Symbol
Inpp4bprovided by MGI
Official Full Name
inositol polyphosphate-4-phosphatase, type IIprovided by MGI
Primary source
MGI:MGI:2158925
See related
Ensembl:ENSMUSG00000037940 AllianceGenome:MGI:2158925
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E130107I17Rik
Summary
Enables lipid binding activity; phosphatidylinositol bisphosphate phosphatase activity; and phosphatidylinositol trisphosphate phosphatase activity. Acts upstream of or within several processes, including negative regulation of osteoclast differentiation; regulation of bone remodeling; and regulation of protein kinase B signaling. Located in Golgi apparatus. Is expressed in several structures, including brain; ear; genitourinary system; heart; and musculoskeletal system. Orthologous to human INPP4B (inositol polyphosphate-4-phosphatase type II B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in heart adult (RPKM 1.6), cerebellum adult (RPKM 1.4) and 22 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 C2; 8 39.02 cM
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (82068895..82865553)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (81342266..82134312)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene coenzyme Q10 homolog B pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr8:83877485-83877786 Neighboring gene STARR-seq mESC enhancer starr_22053 Neighboring gene STARR-seq mESC enhancer starr_22054 Neighboring gene STARR-positive B cell enhancer mm9_chr8:83898997-83899298 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 51582 Neighboring gene STARR-positive B cell enhancer mm9_chr8:84002682-84002982 Neighboring gene STARR-seq mESC enhancer starr_22055 Neighboring gene STARR-seq mESC enhancer starr_22056 Neighboring gene SNARE-associated protein Snapin pseudogene Neighboring gene STARR-seq mESC enhancer starr_22059 Neighboring gene voltage-dependent anion channel 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_22060 Neighboring gene STARR-seq mESC enhancer starr_22061 Neighboring gene STARR-seq mESC enhancer starr_22062 Neighboring gene STARR-seq mESC enhancer starr_22063 Neighboring gene predicted gene, 53442 Neighboring gene predicted gene, 25267 Neighboring gene predicted gene 9520

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. INPP4B protects from metabolic syndrome and associated disorders. Zhang M, et al. Commun Biol, 2021 Mar 26. PMID 33772116, Free PMC Article
  2. Deletion of inositol polyphosphate 4-phosphatase type-II B affects spermatogenesis in mice. Ceyhan Y, et al. PLoS One, 2020. PMID 32413098, Free PMC Article
  3. Investigating the duality of Inpp4b function in the cellular transformation of mouse fibroblasts. Mangialardi EM, et al. Oncotarget, 2019 Oct 29. PMID 31695845, Free PMC Article
  4. Depletion of Inositol Polyphosphate 4-Phosphatase II Suppresses Callosal Axon Formation in the Developing Mice. Ji L, et al. Mol Cells, 2016 Jun 30. PMID 27109423, Free PMC Article
  5. Phosphatidylinositol 4-phosphatase type II is an erythropoietin-responsive gene. Barnache S, et al. Oncogene, 2006 Mar 2. PMID 16247441

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Regulation of B-1 cell numbers and B cell-mediated antibody production by Inpp4b.
    Title: Regulation of B-1 cell numbers and B cell-mediated antibody production by Inpp4b.
  2. Inhibition of lipid kinase PIKfyve reveals a role for phosphatase Inpp4b in the regulation of PI(3)P-mediated lysosome dynamics through VPS34 activity.
    Title: Inhibition of lipid kinase PIKfyve reveals a role for phosphatase Inpp4b in the regulation of PI(3)P-mediated lysosome dynamics through VPS34 activity.
  3. We showed that Inpp4b is an essential regulator of metabolic health. Male Inpp4b knockout mice fed high fat diet develop type 2 diabetes. Inpp4b expression protects the liver from steatosis, mediates insulin sensitivity, and links obesity to neoplastic changes in the prostate epithelium.
    Title: INPP4B protects from metabolic syndrome and associated disorders.
  4. The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer.
    Title: The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer.
  5. Deletion of inositol polyphosphate 4-phosphatase type-II B affects spermatogenesis in mice.
    Title: Deletion of inositol polyphosphate 4-phosphatase type-II B affects spermatogenesis in mice.
  6. data show that INPP4B modulates AR activity in normal prostate and its loss contributes to the AR-dependent transcriptional profile in prostate cancer.
    Title: Inositol polyphosphate 4-phosphatase type II regulation of androgen receptor activity.
  7. Data provides evidence that INPP4B may play a role in regulating callosal axon formation by the formation of Satb2-positive pyramidal neurons and controlling axon polarization.
    Title: Depletion of Inositol Polyphosphate 4-Phosphatase II Suppresses Callosal Axon Formation in the Developing Mice.
  8. Results provide evidence that INPP4B is a bona fide tumor suppressor whose function is particularly important in situations of PTEN deficiency. Biochemical data demonstrates that INPP4B directly dephosphorylates PtdIns(3,4,5)P3.
    Title: INPP4B Is a PtdIns(3,4,5)P3 Phosphatase That Can Act as a Tumor Suppressor.
  9. Study provides evidence that INPP4B loss can promote follicular-like thyroid cancer progression and metastasis in the context of PTEN haploinsufficiency through the isoform-specific regulation of AKT signaling at the endosomes.
    Title: In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes.
  10. ERalpha plays a protective role in bladder cancer initiation and growth at least partly via modulating the INPP4B/Akt pathway.
    Title: Estrogen receptor alpha prevents bladder cancer via INPP4B inhibited akt pathway in vitro and in vivo.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables lipid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol bisphosphate phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol trisphosphate phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within intracellular calcium ion homeostasis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of osteoclast differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphatidylinositol dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of bone remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of nucleocytoplasmic transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
type II inositol 3,4-bisphosphate 4-phosphatase
Names
D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase
phosphatidylinositol-3,4-bisphosphate 4-phosphatase
phosphoinositide 4-phosphatase
NP_001019788.1
NP_001284520.1
NP_001284522.1
NP_001284525.1
XP_006530917.1
XP_006530918.1
XP_006530919.1
XP_006530921.1
XP_006530924.1
XP_006530925.1
XP_006530926.1
XP_011246653.1
XP_011246654.1
XP_017168215.1
XP_017168217.1
XP_017168218.1
XP_030099350.1
XP_036009844.1
XP_036009845.1
XP_036009846.1
XP_036009847.1
XP_036009848.1
XP_036009849.1
XP_036009850.1
XP_036009851.1
XP_036009852.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024617.3 → NP_001019788.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform 2

    See identical proteins and their annotated locations for NP_001019788.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC115778, AK139397, BC064813, DQ296611
    Consensus CDS
    CCDS22446.1
    UniProtKB/Swiss-Prot
    Q6P1Y8
    UniProtKB/TrEMBL
    Q1A6U9
    Related
    ENSMUSP00000044466.7, ENSMUST00000042529.14
    Conserved Domains (1) summary
    cd04048
    Location:39 → 158
    C2A_Copine; C2 domain first repeat in Copine

  2. NM_001297591.1 → NP_001284520.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform 1

    See identical proteins and their annotated locations for NP_001284520.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK139397, AK141502, DQ296613
    Consensus CDS
    CCDS80901.1
    UniProtKB/TrEMBL
    E9PVM3, Q1A6U9
    Related
    ENSMUSP00000150541.2, ENSMUST00000217122.2
    Conserved Domains (1) summary
    cd04048
    Location:39 → 175
    C2A_Copine; C2 domain first repeat in Copine

  3. NM_001297593.1 → NP_001284522.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate internal exon and uses an alternate last exon compared to variant 1. The resulting isoform (3) has shorter and distinct N- and C-termini compared to isoform 1.
    Source sequence(s)
    AC121136, AK141502, DQ296611, DQ296612
    UniProtKB/TrEMBL
    Q1A6V0
    Conserved Domains (1) summary
    cl14603
    Location:25 → 114
    C2; C2 domain

  4. NM_001297596.1 → NP_001284525.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform 4

    See identical proteins and their annotated locations for NP_001284525.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate last exon compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC121136, AK141502, DQ296611
    Consensus CDS
    CCDS80902.1
    UniProtKB/TrEMBL
    E9PVM1, Q1A6V1
    Related
    ENSMUSP00000148972.2, ENSMUST00000215332.2
    Conserved Domains (1) summary
    cd04048
    Location:39 → 175
    C2A_Copine; C2 domain first repeat in Copine

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    82068895..82865553
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153952.1 → XP_036009845.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X4

    UniProtKB/TrEMBL
    Q1A6V1
    Conserved Domains (1) summary
    cd04048
    Location:39 → 175
    C2A_Copine; C2 domain first repeat in Copine

  2. XM_011248351.3 → XP_011246653.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X1

    See identical proteins and their annotated locations for XP_011246653.1

    UniProtKB/TrEMBL
    E9PVM3, Q1A6U9
    Conserved Domains (1) summary
    cd04048
    Location:39 → 175
    C2A_Copine; C2 domain first repeat in Copine

  3. XM_036153951.1 → XP_036009844.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X1

    UniProtKB/TrEMBL
    E9PVM3, Q1A6U9
    Conserved Domains (1) summary
    cd04048
    Location:39 → 175
    C2A_Copine; C2 domain first repeat in Copine

  4. XM_006530855.3 → XP_006530918.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X1

    See identical proteins and their annotated locations for XP_006530918.1

    UniProtKB/TrEMBL
    E9PVM3, Q1A6U9
    Conserved Domains (1) summary
    cd04048
    Location:39 → 175
    C2A_Copine; C2 domain first repeat in Copine

  5. XM_030243490.1 → XP_030099350.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X2

    UniProtKB/TrEMBL
    Q1A6U9
    Conserved Domains (1) summary
    cd04048
    Location:39 → 175
    C2A_Copine; C2 domain first repeat in Copine

  6. XM_006530856.3 → XP_006530919.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X1

    See identical proteins and their annotated locations for XP_006530919.1

    UniProtKB/TrEMBL
    E9PVM3, Q1A6U9
    Conserved Domains (1) summary
    cd04048
    Location:39 → 175
    C2A_Copine; C2 domain first repeat in Copine

  7. XM_006530861.4 → XP_006530924.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X5

    UniProtKB/TrEMBL
    F8WJC1
    Conserved Domains (1) summary
    cl14603
    Location:25 → 114
    C2; C2 domain

  8. XM_017312729.3 → XP_017168218.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X4

    UniProtKB/TrEMBL
    Q1A6V1
    Conserved Domains (1) summary
    cd04048
    Location:39 → 175
    C2A_Copine; C2 domain first repeat in Copine

  9. XM_006530858.4 → XP_006530921.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X3

    See identical proteins and their annotated locations for XP_006530921.1

    UniProtKB/TrEMBL
    E9PVM1, Q1A6V1
    Conserved Domains (1) summary
    cd04048
    Location:39 → 175
    C2A_Copine; C2 domain first repeat in Copine

  10. XM_036153959.1 → XP_036009852.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X10

    UniProtKB/TrEMBL
    Q1A6V1
    Conserved Domains (1) summary
    cd04048
    Location:39 → 175
    C2A_Copine; C2 domain first repeat in Copine

  11. XM_006530854.4 → XP_006530917.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X1

    See identical proteins and their annotated locations for XP_006530917.1

    UniProtKB/TrEMBL
    E9PVM3, Q1A6U9
    Conserved Domains (1) summary
    cd04048
    Location:39 → 175
    C2A_Copine; C2 domain first repeat in Copine

  12. XM_017312728.3 → XP_017168217.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X2

    UniProtKB/TrEMBL
    Q1A6U9
    Conserved Domains (1) summary
    cd04048
    Location:39 → 175
    C2A_Copine; C2 domain first repeat in Copine

  13. XM_036153953.1 → XP_036009846.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X6

    UniProtKB/TrEMBL
    F8WJC1
    Conserved Domains (1) summary
    cl14603
    Location:25 → 97
    C2; C2 domain

  14. XM_036153954.1 → XP_036009847.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X7

    UniProtKB/TrEMBL
    Q3URI3
    Related
    ENSMUSP00000150520.2, ENSMUST00000213285.2
    Conserved Domains (1) summary
    cd04048
    Location:39 → 175
    C2A_Copine; C2 domain first repeat in Copine

  15. XM_011248352.3 → XP_011246654.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X1

    See identical proteins and their annotated locations for XP_011246654.1

    UniProtKB/TrEMBL
    E9PVM3, Q1A6U9
    Conserved Domains (1) summary
    cd04048
    Location:39 → 175
    C2A_Copine; C2 domain first repeat in Copine

  16. XM_017312726.2 → XP_017168215.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X1

    UniProtKB/TrEMBL
    E9PVM3, Q1A6U9
    Conserved Domains (1) summary
    cd04048
    Location:39 → 175
    C2A_Copine; C2 domain first repeat in Copine

  17. XM_036153955.1 → XP_036009848.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X8

    UniProtKB/TrEMBL
    F8WJC1

  18. XM_036153958.1 → XP_036009851.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X8

    UniProtKB/TrEMBL
    F8WJC1
    Related
    ENSMUSP00000132156.2, ENSMUST00000170160.8

  19. XM_006530862.4 → XP_006530925.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X8

    See identical proteins and their annotated locations for XP_006530925.1

    UniProtKB/TrEMBL
    F8WJC1

  20. XM_036153956.1 → XP_036009849.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X9

    UniProtKB/TrEMBL
    Q1A6V0

  21. XM_006530863.5 → XP_006530926.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X8

    See identical proteins and their annotated locations for XP_006530926.1

    UniProtKB/TrEMBL
    F8WJC1
    Related
    ENSMUSP00000105477.3, ENSMUST00000109851.3

  22. XM_036153957.1 → XP_036009850.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X9

    UniProtKB/TrEMBL
    Q1A6V0
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P1Y8.1 GenPept UniProtKB/Swiss-Prot:Q6P1Y8

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