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Fhod1 formin homology 2 domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 234686, updated on 21-Apr-2024

Summary

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Official Symbol
Fhod1provided by MGI
Official Full Name
formin homology 2 domain containing 1provided by MGI
Primary source
MGI:MGI:2679008
See related
Ensembl:ENSMUSG00000014778 AllianceGenome:MGI:2679008
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FHOS; FHOS1
Summary
Predicted to enable several functions, including actin filament binding activity; identical protein binding activity; and protein self-association. Acts upstream of or within establishment of centrosome localization and nuclear migration. Located in intercalated disc. Is expressed in several structures, including alimentary system; metanephros; nervous system; respiratory system; and sensory organ. Orthologous to human FHOD1 (formin homology 2 domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 37.9), spleen adult (RPKM 23.0) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 D3; 8 53.04 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106055792..106074650, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105329160..105348062, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene engulfment and cell motility 3 Neighboring gene microRNA 328 Neighboring gene F-box and leucine-rich repeat protein 9 Neighboring gene STARR-positive B cell enhancer ABC_E11746 Neighboring gene transmembrane protein 208 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:107871965-107872074 Neighboring gene predicted gene, 46049 Neighboring gene solute carrier family 9 (sodium/hydrogen exchanger), member 5 Neighboring gene pleckstrin homology domain containing, family G (with RhoGef domain) member 4 Neighboring gene potassium channel tetramerisation domain containing 19

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. FHOD1 regulates cytoplasmic actin-based spindle migration for mouse oocyte asymmetric cell division. Pan MH, et al. J Cell Physiol, 2018 Mar. PMID 28708292
  2. FHOD1 is needed for directed forces and adhesion maturation during cell spreading and migration. Iskratsch T, et al. Dev Cell, 2013 Dec 9. PMID 24331927, Free PMC Article
  3. Loss of mDia1 and Fhod1 impacts platelet formation but not platelet function. Zuidscherwoude M, et al. Platelets, 2021 Nov 17. PMID 32981398, Free PMC Article
  4. G-protein coupled and ITAM receptor regulation of the formin FHOD1 through Rho kinase in platelets. Thomas SG, et al. J Thromb Haemost, 2011 Aug. PMID 21605332
  5. Fhod1, an actin-organizing formin family protein, is dispensable for cardiac development and function in mice. Sanematsu F, et al. Cytoskeleton (Hoboken), 2019 Feb. PMID 31008549

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Fhod1 appears to be dispensable for normal development and function of the mouse heart, even if a marginal amount of Fhod1 is expressed in the heart.
    Title: Fhod1, an actin-organizing formin family protein, is dispensable for cardiac development and function in mice.
  2. FHOD1 is regulated by ROCK for cytoplasm actin assembly and spindle migration during mouse oocyte meiosis.
    Title: FHOD1 regulates cytoplasmic actin-based spindle migration for mouse oocyte asymmetric cell division.
  3. Report FODH1 expression in cardiomyocytes.
    Title: The formin FHOD1 in cardiomyocytes.
  4. We report here that a major formin in mouse fibroblasts, FHOD1, is recruited to integrin clusters, resulting in actin assembly.
    Title: FHOD1 is needed for directed forces and adhesion maturation during cell spreading and migration.
  5. Letter: G-protein coupled and ITAM receptor regulation of the formin FHOD1 through Rho kinase in platelets.
    Title: G-protein coupled and ITAM receptor regulation of the formin FHOD1 through Rho kinase in platelets.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cortical actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within establishment of centrosome localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within nuclear migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intercalated disc IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with stress fiber ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
FH1/FH2 domain-containing protein 1
Names
formin homolog overexpressed in spleen 1
formin homology 2 domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177699.4 → NP_808367.2  FH1/FH2 domain-containing protein 1

    See identical proteins and their annotated locations for NP_808367.2

    Status: VALIDATED

    Source sequence(s)
    AB041045, AW540395, BB858085
    Consensus CDS
    CCDS22600.1
    UniProtKB/Swiss-Prot
    Q6P9Q4, Q8BMK2
    Related
    ENSMUSP00000014922.5, ENSMUST00000014922.5
    Conserved Domains (1) summary
    pfam02181
    Location:648 → 1020
    FH2; Formin Homology 2 Domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    106055792..106074650 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153970.1 → XP_036009863.1  FH1/FH2 domain-containing protein 1 isoform X1

    Conserved Domains (2) summary
    pfam02181
    Location:674 → 1046
    FH2; Formin Homology 2 Domain
    pfam18382
    Location:17 → 115
    Formin_GBD_N; Formin N-terminal GTPase-binding domain

  2. XM_030243503.1 → XP_030099363.1  FH1/FH2 domain-containing protein 1 isoform X3

    Conserved Domains (1) summary
    pfam02181
    Location:343 → 715
    FH2; Formin Homology 2 Domain

  3. XM_036153971.1 → XP_036009864.1  FH1/FH2 domain-containing protein 1 isoform X2

    Conserved Domains (1) summary
    pfam02181
    Location:369 → 741
    FH2; Formin Homology 2 Domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P9Q4.3 GenPept UniProtKB/Swiss-Prot:Q6P9Q4

Gene LinkOut

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