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Tat tyrosine aminotransferase [ Mus musculus (house mouse) ]

Gene ID: 234724, updated on 5-Jan-2022

Summary

Official Symbol
Tatprovided by MGI
Official Full Name
tyrosine aminotransferaseprovided by MGI
Primary source
MGI:MGI:98487
See related
Ensembl:ENSMUSG00000001670
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
This gene encodes a liver-specific mitochondrial enzyme that catalyzes the conversion of L-tyrosine into p-hydroxyphenylpyruvate. Regulated by glucocorticoid and polypeptide hormones, this gene's expression is affected by deletion of a regulatory region near the albino locus on chromosome 7. Mutations in this gene cause tyrosinemia type II in humans. [provided by RefSeq, Mar 2010]
Expression
Restricted expression toward liver adult (RPKM 449.0) See more
Orthologs
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Genomic context

See Tat in Genome Data Viewer
Location:
8 D3; 8 57.38 cM
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (110712710..110726436)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (109986078..109999804)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (112514336..112523704)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene PH domain and leucine rich repeat protein phosphatase 2 Neighboring gene MARVEL (membrane-associating) domain containing 3 Neighboring gene 40S ribosomal protein S24 pseudogene Neighboring gene RIKEN cDNA 1700064F23 gene Neighboring gene carbohydrate sulfotransferase 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC37772, MGC37789, MGC37790, MGC37819, MGC37828, MGC37842

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-tyrosine:2-oxoglutarate aminotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables L-tyrosine:2-oxoglutarate aminotransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables amino acid binding ISO
Inferred from Sequence Orthology
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
 
enables transaminase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tyrosine aminotransferase
Names
L-tyrosine:2-oxoglutarate aminotransferase
tyrosine transaminase
NP_666326.1
XP_030099366.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_146214.3NP_666326.1  tyrosine aminotransferase

    See identical proteins and their annotated locations for NP_666326.1

    Status: REVIEWED

    Source sequence(s)
    AC124409
    Consensus CDS
    CCDS22658.1
    UniProtKB/Swiss-Prot
    Q8QZR1
    Related
    ENSMUSP00000001720.8, ENSMUST00000001720.14
    Conserved Domains (2) summary
    TIGR01264
    Location:41442
    tyr_amTase_E; tyrosine aminotransferase, eukaryotic
    pfam07706
    Location:140
    TAT_ubiq; Aminotransferase ubiquitination site

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    110712710..110726436
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243506.1XP_030099366.1  tyrosine aminotransferase isoform X1

    Conserved Domains (2) summary
    TIGR01264
    Location:41442
    tyr_amTase_E; tyrosine aminotransferase, eukaryotic
    pfam07706
    Location:140
    TAT_ubiq; Aminotransferase ubiquitination site
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