FOLR2 folate receptor beta [Homo sapiens (human)] - Gene

Summary

Official Symbol: FOLR2provided by HGNC
Official Full Name: folate receptor betaprovided by HGNC
Primary source: HGNC:HGNC:3793
See related: Ensembl:ENSG00000165457 MIM:136425; AllianceGenome:HGNC:3793
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FBP; FOLR1; FR-P3; FRbeta; FR-BETA; BETA-HFR; FBP/PL-1
Summary: The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression: Broad expression in placenta (RPKM 67.9), gall bladder (RPKM 33.0) and 20 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11q13.4

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (72216794..72221950)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (72143410..72148566)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (71927838..71932994)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

microRNA-622 upregulates cell cycle process by targeting FOLR2 to promote CRC proliferation.
Title: microRNA-622 upregulates cell cycle process by targeting FOLR2 to promote CRC proliferation.
Mutational analysis of FOLR1 and FOLR2 genes in children with Myelomeningocele.
Title: Mutational analysis of FOLR1 and FOLR2 genes in children with Myelomeningocele.
FOLR2+ Macrophages Are Associated with T-cell Infiltration and Improved Prognosis.
Title: FOLR2+ Macrophages Are Associated with T-cell Infiltration and Improved Prognosis.
Association of periconceptional folate supplements and FOLR1 and FOLR2 gene polymorphisms with risk of congenital heart disease in offspring: A hospital-based case-control study.", trans "FOLR1FOLR2.
Title: Association of periconceptional folate supplements and FOLR1 and FOLR2 gene polymorphisms with risk of congenital heart disease in offspring: A hospital-based case-control study.
Folate Receptor Expression by Human Monocyte-Derived Macrophage Subtypes and Effects of Corticosteroids.
Title: Folate Receptor Expression by Human Monocyte-Derived Macrophage Subtypes and Effects of Corticosteroids.
Folate Receptor Beta for Macrophage Imaging in Rheumatoid Arthritis.
Title: Folate Receptor Beta for Macrophage Imaging in Rheumatoid Arthritis.
Targeting folate receptor beta on monocytes/macrophages renders rapid inflammation resolution independent of root causes.
Title: Targeting folate receptor beta on monocytes/macrophages renders rapid inflammation resolution independent of root causes.
Targeting folate receptor beta positive tumor-associated macrophages in lung cancer with a folate-modified liposomal complex.
Title: Targeting folate receptor β positive tumor-associated macrophages in lung cancer with a folate-modified liposomal complex.
Folate Receptor Beta as a Direct and Indirect Target for Antibody-Based Cancer Immunotherapy.
Title: Folate Receptor Beta as a Direct and Indirect Target for Antibody-Based Cancer Immunotherapy.
Folate Receptor beta (FRbeta) Expression in Tissue-Resident and Tumor-Associated Macrophages Associates with and Depends on the Expression of PU.1.
Title: Folate Receptor β (FRβ) Expression in Tissue-Resident and Tumor-Associated Macrophages Associates with and Depends on the Expression of PU.1.

Submit: New GeneRIF Correction See all GeneRIFs (32)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope transmembrane glycoprotein gp41	env	A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of folate receptor 2 (FOLR2) in peptide-treated PBMCs	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S4329 (e-PCR)
- UniSTS:43548

D11S1142 (e-PCR)
- UniSTS:44889

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables folic acid binding	IDA Inferred from Direct Assay more info	PubMed
enables folic acid receptor activity	IC Inferred by Curator more info	PubMed
enables folic acid receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to folic acid	IEA Inferred from Electronic Annotation more info
involved_in folic acid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in fusion of sperm to egg plasma membrane involved in single fertilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	NAS Non-traceable Author Statement more info	PubMed
NOT involved_in monocyte chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sperm-egg recognition	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: folate receptor beta

Names: folate receptor 2 (fetal); folate receptor alpha; folate receptor, fetal/placental; folate-binding protein, fetal/placental; placental folate-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_000803.5 → NP_000794.3 folate receptor beta precursor

See identical proteins and their annotated locations for NP_000794.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript. All variants (1-4) encode the same protein.

Source sequence(s)

AK222643, CD014063

Consensus CDS

CCDS8212.1

UniProtKB/Swiss-Prot

P14207, Q05CA5, Q6GTE8

UniProtKB/TrEMBL

Q53HP1

Related

ENSP00000298223.6, ENST00000298223.11

Conserved Domains (1) summary

pfam03024
Location:30 → 205

Folate_rec; Folate receptor family
NM_001113534.2 → NP_001107006.1 folate receptor beta precursor

See identical proteins and their annotated locations for NP_001107006.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. All variants (1-4) encode the same protein.

Source sequence(s)

BM849995, CD014063, CD692073

Consensus CDS

CCDS8212.1

UniProtKB/Swiss-Prot

P14207, Q05CA5, Q6GTE8

UniProtKB/TrEMBL

Q53HP1

Conserved Domains (1) summary

pfam03024
Location:30 → 205

Folate_rec; Folate receptor family
NM_001113535.2 → NP_001107007.1 folate receptor beta precursor

See identical proteins and their annotated locations for NP_001107007.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. All variants (1-4) encode the same protein.

Source sequence(s)

BM691283, BM849995, CD014063

Consensus CDS

CCDS8212.1

UniProtKB/Swiss-Prot

P14207, Q05CA5, Q6GTE8

UniProtKB/TrEMBL

Q53HP1

Conserved Domains (1) summary

pfam03024
Location:30 → 205

Folate_rec; Folate receptor family
NM_001113536.2 → NP_001107008.1 folate receptor beta precursor

See identical proteins and their annotated locations for NP_001107008.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. All variants (1-4) encode the same protein.

Source sequence(s)

BY797003, CD014063

Consensus CDS

CCDS8212.1

UniProtKB/Swiss-Prot

P14207, Q05CA5, Q6GTE8

UniProtKB/TrEMBL

Q53HP1

Conserved Domains (1) summary

pfam03024
Location:30 → 205

Folate_rec; Folate receptor family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000011.10 Reference GRCh38.p14 Primary Assembly

Range

72216794..72221950

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047426683.1 → XP_047282639.1 folate receptor beta isoform X2

UniProtKB/Swiss-Prot

P14207, Q05CA5, Q6GTE8
XM_005273856.5 → XP_005273913.1 folate receptor beta isoform X1

UniProtKB/TrEMBL

Q53HP1

Conserved Domains (1) summary

pfam03024
Location:39 → 214

Folate_rec; Folate receptor family