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Sik2 salt inducible kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 235344, updated on 5-Sep-2021

Summary

Official Symbol
Sik2provided by MGI
Official Full Name
salt inducible kinase 2provided by MGI
Primary source
MGI:MGI:2445031
See related
Ensembl:ENSMUSG00000037112
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Snf1; Snf1lk2; G630080D20Rik
Expression
Broad expression in subcutaneous fat pad adult (RPKM 39.2), mammary gland adult (RPKM 30.6) and 24 other tissues See more
Orthologs
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Genomic context

See Sik2 in Genome Data Viewer
Location:
9; 9 A5.3
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (50800944..50920432, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (50889644..51009132, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (50700906..50817178, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA48 Neighboring gene asparagine-linked glycosylation 9 (alpha 1,2 mannosyltransferase) Neighboring gene protein phosphatase 2, regulatory subunit A, beta Neighboring gene predicted gene, 25558 Neighboring gene predicted gene, 32681 Neighboring gene layilin Neighboring gene HOATZ cilia and flagella associated protein Neighboring gene microRNA 34c Neighboring gene BTG anti-proliferation factor 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase SIK2
Names
SIK-2
SNF1-like kinase 2
salt induceable kinase 2
salt-inducible protein kinase 2
serine/threonine-protein kinase SNF1-like kinase 2
NP_848825.2
XP_006510329.1
XP_006510330.1
XP_017168821.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178710.3NP_848825.2  serine/threonine-protein kinase SIK2

    See identical proteins and their annotated locations for NP_848825.2

    Status: VALIDATED

    Source sequence(s)
    AB067780, AI605180, AK090386, BB635920
    Consensus CDS
    CCDS40627.1
    UniProtKB/Swiss-Prot
    Q8CFH6
    UniProtKB/TrEMBL
    F8VPT7
    Related
    ENSMUSP00000038761.11, ENSMUST00000041375.11
    Conserved Domains (3) summary
    smart00220
    Location:20271
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14409
    Location:297341
    UBA_SIK2; UBA domain found in salt-inducible kinase 2 (SIK2)
    cd14071
    Location:19271
    STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    50800944..50920432 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510267.3XP_006510330.1  serine/threonine-protein kinase SIK2 isoform X2

    Conserved Domains (2) summary
    cd14409
    Location:297341
    UBA_SIK2; UBA domain found in salt-inducible kinase 2 (SIK2)
    cd14071
    Location:19271
    STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases
  2. XM_017313332.3XP_017168821.1  serine/threonine-protein kinase SIK2 isoform X3

    Conserved Domains (2) summary
    cd14409
    Location:297341
    UBA_SIK2; UBA domain found in salt-inducible kinase 2 (SIK2)
    cd14071
    Location:19271
    STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases
  3. XM_006510266.3XP_006510329.1  serine/threonine-protein kinase SIK2 isoform X1

    UniProtKB/TrEMBL
    H3BKG1
    Related
    ENSMUSP00000135376.2, ENSMUST00000176663.8
    Conserved Domains (2) summary
    cd14409
    Location:297341
    UBA_SIK2; UBA domain found in salt-inducible kinase 2 (SIK2)
    cd14071
    Location:19271
    STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases

RNA

  1. XR_379116.2 RNA Sequence

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