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Slc17a5 solute carrier family 17 (anion/sugar transporter), member 5 [ Mus musculus (house mouse) ]

Gene ID: 235504, updated on 5-Jan-2022

Summary

Official Symbol
Slc17a5provided by MGI
Official Full Name
solute carrier family 17 (anion/sugar transporter), member 5provided by MGI
Primary source
MGI:MGI:1924105
See related
Ensembl:ENSMUSG00000049624
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SD; AST; NSD; SLD; ISSD; SIASD; SIALIN; 4732491M05; 4631416G20Rik
Summary
Predicted to enable sialic acid transmembrane transporter activity. Acts upstream of or within response to bacterium. Located in cytoplasmic vesicle and plasma membrane. Is expressed in several structures, including gut; liver; metanephros; nervous system; and sensory organ epithelium. Used to study lysosomal storage disease and sialuria. Human ortholog(s) of this gene implicated in sialuria. Orthologous to human SLC17A5 (solute carrier family 17 member 5). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in kidney adult (RPKM 12.0), genital fat pad adult (RPKM 7.5) and 28 other tissues See more
Orthologs
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Genomic context

See Slc17a5 in Genome Data Viewer
Location:
9; 9 E1
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (78443769..78495346, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (78536487..78588045, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (78384316..78435834, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 alpha 1 Neighboring gene predicted gene, 53210 Neighboring gene CD109 antigen Neighboring gene predicted gene, 46138

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables sialic acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables sialic acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within amino acid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in anion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in sialic acid transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within sialic acid transport ISO
Inferred from Sequence Orthology
more info
 
involved_in sialic acid transport ISO
Inferred from Sequence Orthology
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
sialin
Names
H(+)/nitrate cotransporter
sodium/sialic acid cotransporter
vesicular H(+)/Aspartate-glutamate cotransporter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276452.1NP_001263381.1  sialin isoform b

    See identical proteins and their annotated locations for NP_001263381.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. It encodes isoform b which is shorter than isoform a.
    Source sequence(s)
    AC159883, BC058785, BE630039
    Consensus CDS
    CCDS72283.1
    UniProtKB/Swiss-Prot
    Q8BN82
    Related
    ENSMUSP00000113003.2, ENSMUST00000117645.8
    Conserved Domains (2) summary
    cd06174
    Location:98452
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00894
    Location:30465
    2A0114euk; Na(+)-dependent inorganic phosphate cotransporter
  2. NM_172773.3NP_766361.1  sialin isoform a

    See identical proteins and their annotated locations for NP_766361.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC159883, AK029102, BE630039
    Consensus CDS
    CCDS23364.1
    UniProtKB/Swiss-Prot
    Q8BN82
    Related
    ENSMUSP00000056182.6, ENSMUST00000052441.12
    Conserved Domains (2) summary
    cd06174
    Location:99478
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00894
    Location:30491
    2A0114euk; Na(+)-dependent inorganic phosphate cotransporter

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    78443769..78495346 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154911.1XP_036010804.1  sialin isoform X2

    Conserved Domains (1) summary
    cl28910
    Location:42373
    MFS; Major Facilitator Superfamily
  2. XM_011242737.3XP_011241039.1  sialin isoform X3

    Conserved Domains (1) summary
    cl28910
    Location:1297
    MFS; Major Facilitator Superfamily
  3. XM_017313345.2XP_017168834.1  sialin isoform X3

    Conserved Domains (1) summary
    cl28910
    Location:1297
    MFS; Major Facilitator Superfamily
  4. XM_006511128.5XP_006511191.1  sialin isoform X1

    Conserved Domains (1) summary
    cd17381
    Location:19455
    MFS_SLC17A5; Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters

RNA

  1. XR_004935422.1 RNA Sequence

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