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Zfp65 zinc finger protein 65 [ Mus musculus (house mouse) ]

Gene ID: 235907, updated on 8-Feb-2024

Summary

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Official Symbol
Zfp65provided by MGI
Official Full Name
zinc finger protein 65provided by MGI
Primary source
MGI:MGI:107769
See related
Ensembl:ENSMUSG00000071281 AllianceGenome:MGI:107769
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KRAB5; pz114; Zfp71-rs1
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in early conceptus and inner cell mass. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 1.3), whole brain E14.5 (RPKM 1.1) and 23 other tissues See more
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Genomic context

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Location:
13 B3; 13 34.7 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (67853428..67877238, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (67705306..67729178, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46439 Neighboring gene STARR-seq mESC enhancer starr_34906 Neighboring gene zinc finger protein 738 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:67784456-67784643 Neighboring gene STARR-seq mESC enhancer starr_34907 Neighboring gene zinc finger protein 85, opposite strand Neighboring gene STARR-seq mESC enhancer starr_34908 Neighboring gene STARR-seq mESC enhancer starr_34909 Neighboring gene STARR-seq mESC enhancer starr_34910 Neighboring gene zinc finger protein 85 Neighboring gene zinc finger protein 85, related sequence 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea. Bellefroid EJ, et al. Proc Natl Acad Sci U S A, 1995 Nov 7. PMID 7479878, Free PMC Article
  2. Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia. Ihle JN, et al. J Virol, 1989 Jul. PMID 2542606, Free PMC Article
  3. Chromosomal location of fifteen unique mouse KRAB-containing zinc finger loci. Marine JC, et al. Mamm Genome, 1996 Jun. PMID 8662221
  4. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
  5. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 71, related sequence
Names
zinc finger protein 71, related sequence 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001402903.1 → NP_001389832.1  zinc finger protein 71, related sequence isoform 2

    Status: VALIDATED

    Source sequence(s)
    CT030194
    Related
    ENSMUSP00000123380.3, ENSMUST00000130891.3

  2. NM_001402904.1 → NP_001389833.1  zinc finger protein 71, related sequence isoform 1

    Status: VALIDATED

    Source sequence(s)
    CT030194
    UniProtKB/TrEMBL
    Q91W94

  3. NM_001402906.1 → NP_001389835.1  zinc finger protein 71, related sequence isoform 4

    Status: VALIDATED

    Source sequence(s)
    CT030194

  4. NM_001402907.1 → NP_001389836.1  zinc finger protein 71, related sequence isoform 4

    Status: VALIDATED

    Source sequence(s)
    CT030194

  5. NM_145622.3 → NP_663597.1  zinc finger protein 71, related sequence isoform 1

    See identical proteins and their annotated locations for NP_663597.1

    Status: VALIDATED

    Source sequence(s)
    CT030194
    Consensus CDS
    CCDS49303.1
    UniProtKB/TrEMBL
    Q91W94
    Related
    ENSMUSP00000072900.7, ENSMUST00000073157.15
    Conserved Domains (3) summary
    smart00349
    Location:5 → 62
    KRAB; krueppel associated box
    COG5048
    Location:106 → 363
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:223 → 243
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    67853428..67877238 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247250.1 → XP_030103110.1  zinc finger protein 71, related sequence isoform X3

    Conserved Domains (3) summary
    smart00349
    Location:2 → 59
    KRAB; krueppel associated box
    COG5048
    Location:103 → 360
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:220 → 240
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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