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Phgdh 3-phosphoglycerate dehydrogenase [ Mus musculus (house mouse) ]

Gene ID: 236539, updated on 5-Jan-2022

Summary

Official Symbol
Phgdhprovided by MGI
Official Full Name
3-phosphoglycerate dehydrogenaseprovided by MGI
Primary source
MGI:MGI:1355330
See related
Ensembl:ENSMUSG00000053398
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A10; PGD; PGAD; PGDH; SERA; 3PGDH; 3-PGDH; 4930479N23
Summary
Predicted to enable phosphoglycerate dehydrogenase activity. Acts upstream of or within several processes, including G1 to G0 transition; cellular amino acid metabolic process; and nervous system development. Located in myelin sheath. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in Neu-Laxova syndrome 1; PHGDH deficiency; and amino acid metabolic disorder. Orthologous to human PHGDH (phosphoglycerate dehydrogenase). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Broad expression in placenta adult (RPKM 138.0), genital fat pad adult (RPKM 127.9) and 25 other tissues See more
Orthologs
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Genomic context

See Phgdh in Genome Data Viewer
Location:
3; 3 F2.2
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (98220487..98247285, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (98313171..98339969, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (98117094..98143892, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene regenerating islet-derived family, member 4 Neighboring gene 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 Neighboring gene predicted gene, 31420 Neighboring gene zinc finger protein 697 Neighboring gene hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 9

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC113796, MGC117966

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
 
enables phosphoglycerate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphoglycerate dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphoglycerate dehydrogenase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G1 to G0 transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within L-serine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in L-serine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within L-serine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within gamma-aminobutyric acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glial cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glutamine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glycine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neural tube development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spinal cord development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within taurine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within threonine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in myelin sheath HDA PubMed 

General protein information

Preferred Names
D-3-phosphoglycerate dehydrogenase
Names
3-phosphoglycerate dehyrogenase
NP_058662.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016966.3NP_058662.2  D-3-phosphoglycerate dehydrogenase

    See identical proteins and their annotated locations for NP_058662.2

    Status: VALIDATED

    Source sequence(s)
    AK076815, AW545294, BY290664
    Consensus CDS
    CCDS17663.1
    UniProtKB/Swiss-Prot
    Q61753
    Related
    ENSMUSP00000064755.6, ENSMUST00000065793.12
    Conserved Domains (2) summary
    PRK13581
    Location:8490
    PRK13581; D-3-phosphoglycerate dehydrogenase; Provisional
    cd12173
    Location:8310
    PGDH_4; Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    98220487..98247285 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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