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Adgrg2 adhesion G protein-coupled receptor G2 [ Mus musculus (house mouse) ]

Gene ID: 237175, updated on 21-Apr-2024

Summary

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Official Symbol
Adgrg2provided by MGI
Official Full Name
adhesion G protein-coupled receptor G2provided by MGI
Primary source
MGI:MGI:2446854
See related
Ensembl:ENSMUSG00000031298 AllianceGenome:MGI:2446854
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Me6; Gpr64; B830041D06Rik
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in apical plasma membrane and cytosol. Predicted to be integral component of plasma membrane. Is expressed in dorsal root ganglion; facial ganglion; foot; hand; and trigeminal ganglion. Human ortholog(s) of this gene implicated in X-linked congenital bilateral absence of vas deferens. Orthologous to human ADGRG2 (adhesion G protein-coupled receptor G2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in genital fat pad adult (RPKM 104.9) and limb E14.5 (RPKM 8.2) See more
Orthologs
human all
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Genomic context

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Location:
X F4; X 73.95 cM
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (159173315..159281072)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (160390318..160498076)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39548 Neighboring gene abl-interactor 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_48182 Neighboring gene predicted gene 15241 Neighboring gene phosphorylase kinase alpha 2 Neighboring gene STARR-seq mESC enhancer starr_48183 Neighboring gene protein phosphatase with EF hand calcium-binding domain 1 Neighboring gene STARR-seq mESC enhancer starr_48184

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Adhesion receptor ADGRG2/GPR64 is in the GI-tract selectively expressed in mature intestinal tuft cells. Grunddal KV, et al. Mol Metab, 2021 Sep. PMID 33831593, Free PMC Article
  2. Optimization of a peptide ligand for the adhesion GPCR ADGRG2 provides a potent tool to explore receptor biology. Sun Y, et al. J Biol Chem, 2021 Jan-Jun. PMID 33303626, Free PMC Article
  3. Identification of the tethered peptide agonist of the adhesion G protein-coupled receptor GPR64/ADGRG2. Demberg LM, et al. Biochem Biophys Res Commun, 2015 Aug 28. PMID 26188515
  4. HE6/GPR64 adhesion receptor co-localizes with apical and subapical F-actin scaffold in male excurrent duct epithelia. Kirchhoff C, et al. Reproduction, 2008 Aug. PMID 18469038
  5. Targeted deletion of the epididymal receptor HE6 results in fluid dysregulation and male infertility. Davies B, et al. Mol Cell Biol, 2004 Oct. PMID 15367682, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Adhesion receptor ADGRG2/GPR64 is in the GI-tract selectively expressed in mature intestinal tuft cells.
    Title: Adhesion receptor ADGRG2/GPR64 is in the GI-tract selectively expressed in mature intestinal tuft cells.
  2. Optimization of a peptide ligand for the adhesion GPCR ADGRG2 provides a potent tool to explore receptor biology.
    Title: Optimization of a peptide ligand for the adhesion GPCR ADGRG2 provides a potent tool to explore receptor biology.
  3. The authors demonstrated that the ubiquitous G protein-coupled receptor signaling proteins Gq and beta-arrestin-1 are essential for fluid reabsorption because they mediate coupling between an orphan receptor ADGRG2 (GPR64) and the ion channel CFTR.
    Title: Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility.
  4. Study identified Gpr64 as a P4-PGR target gene in the mouse uterus. P4 induced GPR64 expression in the epithelial and stromal cells of the uterus in ovariectomized wild-type mice, but not in PRKO mice. ChIP analysis confirmed that PGR proteins were recruited on progesterone response element of Gpr64 gene in the uteri of wild-type mice treated with P4.
    Title: G-protein coupled receptor 64 is required for decidualization of endometrial stromal cells.
  5. examined the G protein-coupling abilities of GPR64 and showed that it is activated through a tethered agonist sequence, which we have previously identified as the Stachel sequence
    Title: Identification of the tethered peptide agonist of the adhesion G protein-coupled receptor GPR64/ADGRG2.
  6. GPR64 expression in ES maintains an immature phenotype that is less sensitive to TRAIL-induced apoptosis and via its up-regulation of PGF and MMP1 orchestrates and promotes invasiveness and metastatic spread in Ewing sarcoma.
    Title: G-Protein coupled receptor 64 promotes invasiveness and metastasis in Ewing sarcomas through PGF and MMP1.
  7. Affymetrix expression profiling shows that the C terminus of Runx2 regulates genes involved in G protein-coupled receptor signaling Rgs2, Rgs4, Rgs5, Rgs16, Gpr23, Gpr30, Gpr54, Gpr64, and Gna13.
    Title: Runx2 regulates G protein-coupled signaling pathways to control growth of osteoblast progenitors.
  8. The knockout of the HE6/Gpr64 receptor was mainly associated with the downregulation of genes specific to the initial segment.
    Title: Novel epididymis-specific mRNAs downregulated by HE6/Gpr64 receptor gene disruption.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
adhesion G-protein coupled receptor G2
Names
G protein coupled receptor He6
G-protein coupled receptor 64
LNB-TM7 heptahelical receptor Me6
epididymis-specific protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079847.2 → NP_001073316.1  adhesion G-protein coupled receptor G2 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001073316.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site and lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AL731801, BC115874, BY769670
    Consensus CDS
    CCDS41198.1
    UniProtKB/TrEMBL
    A2AHQ2, Q14BH6
    Related
    ENSMUSP00000108020.2, ENSMUST00000112401.8
    Conserved Domains (4) summary
    cd15444
    Location:600 → 869
    7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:544 → 587
    GPS; GPCR proteolysis site, GPS, motif
    pfam03154
    Location:196 → 469
    Atrophin-1; Atrophin-1 family
    NF033913
    Location:222 → 342
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  2. NM_001079848.2 → NP_001073317.1  adhesion G-protein coupled receptor G2 isoform 4

    See identical proteins and their annotated locations for NP_001073317.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AL731801, BC115874, BY769670
    Consensus CDS
    CCDS41199.1
    UniProtKB/TrEMBL
    A2AHQ2
    Related
    ENSMUSP00000108023.3, ENSMUST00000112404.9
    Conserved Domains (4) summary
    cd15444
    Location:590 → 859
    7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:534 → 577
    GPS; GPCR proteolysis site, GPS, motif
    pfam03154
    Location:186 → 459
    Atrophin-1; Atrophin-1 family
    NF033913
    Location:212 → 332
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  3. NM_001079857.2 → NP_001073326.1  adhesion G-protein coupled receptor G2 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK046871, AL731801, BC115874, BY769670
    Consensus CDS
    CCDS41197.1
    UniProtKB/TrEMBL
    A2AHQ2
    Related
    ENSMUSP00000108021.2, ENSMUST00000112402.8
    Conserved Domains (4) summary
    cd15444
    Location:603 → 872
    7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:547 → 590
    GPS; GPCR proteolysis site, GPS, motif
    pfam03154
    Location:199 → 472
    Atrophin-1; Atrophin-1 family
    NF033913
    Location:225 → 345
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  4. NM_001290445.1 → NP_001277374.1  adhesion G-protein coupled receptor G2 isoform 5 precursor

    See identical proteins and their annotated locations for NP_001277374.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
    Source sequence(s)
    AL731801, BC115874, BY769670
    Consensus CDS
    CCDS81192.1
    UniProtKB/TrEMBL
    A2AHQ2
    Related
    ENSMUSP00000108024.3, ENSMUST00000112405.9
    Conserved Domains (3) summary
    pfam01825
    Location:546 → 588
    GPS; GPCR proteolysis site, GPS, motif
    pfam16788
    Location:206 → 357
    ATF7IP_BD; ATF-interacting protein binding domain
    cl21561
    Location:601 → 851
    7tm_4; Olfactory receptor

  5. NM_001290446.1 → NP_001277375.1  adhesion G-protein coupled receptor G2 isoform 6 precursor

    See identical proteins and their annotated locations for NP_001277375.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (6) is shorter than isoform 1.
    Source sequence(s)
    AL731801, BC115874, BY769670
    Consensus CDS
    CCDS72459.1
    UniProtKB/TrEMBL
    A2AHQ2
    Related
    ENSMUSP00000108027.3, ENSMUST00000112408.9
    Conserved Domains (4) summary
    cd15444
    Location:614 → 883
    7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:558 → 601
    GPS; GPCR proteolysis site, GPS, motif
    pfam03154
    Location:210 → 483
    Atrophin-1; Atrophin-1 family
    NF033913
    Location:236 → 356
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  6. NM_178712.4 → NP_848827.1  adhesion G-protein coupled receptor G2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_848827.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL731801, BC116644, BY769670
    Consensus CDS
    CCDS41196.1
    UniProtKB/Swiss-Prot
    A2AHP8, A2AHP9, A2AHQ0, A2AHQ3, Q8BL10, Q8CJ08, Q8CJ09, Q8CJ10, Q8CJ12
    UniProtKB/TrEMBL
    A2AHQ2, Q14AX7
    Related
    ENSMUSP00000108019.2, ENSMUST00000112400.8
    Conserved Domains (4) summary
    cd15444
    Location:617 → 886
    7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:561 → 604
    GPS; GPCR proteolysis site, GPS, motif
    pfam03154
    Location:213 → 486
    Atrophin-1; Atrophin-1 family
    NF033913
    Location:239 → 359
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    159173315..159281072
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247817.4 → XP_011246119.1  adhesion G-protein coupled receptor G2 isoform X10

    See identical proteins and their annotated locations for XP_011246119.1

    UniProtKB/TrEMBL
    A2AHQ2
    Conserved Domains (4) summary
    cd15444
    Location:624 → 893
    7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:561 → 611
    GPS; GPCR proteolysis site, GPS, motif
    pfam03154
    Location:213 → 486
    Atrophin-1; Atrophin-1 family
    NF033913
    Location:239 → 359
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  2. XM_017318479.3 → XP_017173968.1  adhesion G-protein coupled receptor G2 isoform X10

    UniProtKB/TrEMBL
    A2AHQ2
    Conserved Domains (4) summary
    cd15444
    Location:624 → 893
    7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:561 → 611
    GPS; GPCR proteolysis site, GPS, motif
    pfam03154
    Location:213 → 486
    Atrophin-1; Atrophin-1 family
    NF033913
    Location:239 → 359
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  3. XM_030251333.2 → XP_030107193.1  adhesion G-protein coupled receptor G2 isoform X24

    UniProtKB/TrEMBL
    A2AHQ2
    Conserved Domains (4) summary
    PRK14948
    Location:275 → 466
    PRK14948; DNA polymerase III subunit gamma/tau
    cd15444
    Location:607 → 876
    7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:544 → 594
    GPS; GPCR proteolysis site, GPS, motif
    pfam03154
    Location:195 → 330
    Atrophin-1; Atrophin-1 family

  4. XM_036161943.1 → XP_036017836.1  adhesion G-protein coupled receptor G2 isoform X23

    UniProtKB/TrEMBL
    A2AHQ2
    Conserved Domains (4) summary
    PHA03369
    Location:236 → 546
    PHA03369; capsid maturational protease; Provisional
    cd15444
    Location:610 → 879
    7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:547 → 597
    GPS; GPCR proteolysis site, GPS, motif
    NF033913
    Location:225 → 345
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  5. XM_030251334.2 → XP_030107194.1  adhesion G-protein coupled receptor G2 isoform X21

    UniProtKB/TrEMBL
    A2AHQ2
    Conserved Domains (4) summary
    cd15444
    Location:583 → 852
    7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:520 → 570
    GPS; GPCR proteolysis site, GPS, motif
    pfam03154
    Location:172 → 445
    Atrophin-1; Atrophin-1 family
    NF033913
    Location:198 → 318
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  6. XM_006528824.5 → XP_006528887.1  adhesion G-protein coupled receptor G2 isoform X10

    See identical proteins and their annotated locations for XP_006528887.1

    UniProtKB/TrEMBL
    A2AHQ2
    Conserved Domains (4) summary
    cd15444
    Location:624 → 893
    7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:561 → 611
    GPS; GPCR proteolysis site, GPS, motif
    pfam03154
    Location:213 → 486
    Atrophin-1; Atrophin-1 family
    NF033913
    Location:239 → 359
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  7. XM_006528827.5 → XP_006528890.1  adhesion G-protein coupled receptor G2 isoform X22

    UniProtKB/TrEMBL
    A2AHQ2
    Conserved Domains (4) summary
    PRK14948
    Location:289 → 480
    PRK14948; DNA polymerase III subunit gamma/tau
    cd15444
    Location:621 → 890
    7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:558 → 608
    GPS; GPCR proteolysis site, GPS, motif
    pfam03154
    Location:209 → 344
    Atrophin-1; Atrophin-1 family

  8. XM_006528829.4 → XP_006528892.1  adhesion G-protein coupled receptor G2 isoform X18

    UniProtKB/TrEMBL
    A2AHQ2
    Conserved Domains (4) summary
    cd15444
    Location:597 → 866
    7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:534 → 584
    GPS; GPCR proteolysis site, GPS, motif
    pfam03154
    Location:186 → 459
    Atrophin-1; Atrophin-1 family
    NF033913
    Location:212 → 332
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  9. XM_036161933.1 → XP_036017826.1  adhesion G-protein coupled receptor G2 isoform X10

    UniProtKB/TrEMBL
    A2AHQ2
    Conserved Domains (4) summary
    cd15444
    Location:624 → 893
    7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:561 → 611
    GPS; GPCR proteolysis site, GPS, motif
    pfam03154
    Location:213 → 486
    Atrophin-1; Atrophin-1 family
    NF033913
    Location:239 → 359
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  10. XM_036161939.1 → XP_036017832.1  adhesion G-protein coupled receptor G2 isoform X18

    UniProtKB/TrEMBL
    A2AHQ2
    Conserved Domains (4) summary
    cd15444
    Location:597 → 866
    7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:534 → 584
    GPS; GPCR proteolysis site, GPS, motif
    pfam03154
    Location:186 → 459
    Atrophin-1; Atrophin-1 family
    NF033913
    Location:212 → 332
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  11. XM_036161934.1 → XP_036017827.1  adhesion G-protein coupled receptor G2 isoform X12

    UniProtKB/Swiss-Prot
    A2AHP8, A2AHP9, A2AHQ0, A2AHQ3, Q8BL10, Q8CJ08, Q8CJ09, Q8CJ10, Q8CJ12
    UniProtKB/TrEMBL
    A2AHQ2, Q14AX7
    Conserved Domains (4) summary
    cd15444
    Location:617 → 886
    7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:561 → 604
    GPS; GPCR proteolysis site, GPS, motif
    pfam03154
    Location:213 → 486
    Atrophin-1; Atrophin-1 family
    NF033913
    Location:239 → 359
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  12. XM_036161935.1 → XP_036017828.1  adhesion G-protein coupled receptor G2 isoform X13

    UniProtKB/TrEMBL
    A2AHQ2
    Related
    ENSMUSP00000108017.3, ENSMUST00000112398.3
    Conserved Domains (4) summary
    cd15444
    Location:614 → 883
    7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:558 → 601
    GPS; GPCR proteolysis site, GPS, motif
    pfam03154
    Location:210 → 483
    Atrophin-1; Atrophin-1 family
    NF033913
    Location:236 → 356
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  13. XM_036161942.1 → XP_036017835.1  adhesion G-protein coupled receptor G2 isoform X21

    UniProtKB/TrEMBL
    A2AHQ2
    Conserved Domains (4) summary
    cd15444
    Location:583 → 852
    7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:520 → 570
    GPS; GPCR proteolysis site, GPS, motif
    pfam03154
    Location:172 → 445
    Atrophin-1; Atrophin-1 family
    NF033913
    Location:198 → 318
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  14. XM_036161937.1 → XP_036017830.1  adhesion G-protein coupled receptor G2 isoform X16

    UniProtKB/TrEMBL
    A2AHQ2
    Conserved Domains (4) summary
    cd15444
    Location:603 → 872
    7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:547 → 590
    GPS; GPCR proteolysis site, GPS, motif
    pfam03154
    Location:199 → 472
    Atrophin-1; Atrophin-1 family
    NF033913
    Location:225 → 345
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  15. XM_036161938.1 → XP_036017831.1  adhesion G-protein coupled receptor G2 isoform X17

    UniProtKB/TrEMBL
    A2AHQ2, Q14BH6
    Conserved Domains (4) summary
    cd15444
    Location:600 → 869
    7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:544 → 587
    GPS; GPCR proteolysis site, GPS, motif
    pfam03154
    Location:196 → 469
    Atrophin-1; Atrophin-1 family
    NF033913
    Location:222 → 342
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  16. XM_036161941.1 → XP_036017834.1  adhesion G-protein coupled receptor G2 isoform X20

    UniProtKB/TrEMBL
    A2AHQ2
    Conserved Domains (4) summary
    cd15444
    Location:590 → 859
    7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:534 → 577
    GPS; GPCR proteolysis site, GPS, motif
    pfam03154
    Location:186 → 459
    Atrophin-1; Atrophin-1 family
    NF033913
    Location:212 → 332
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  17. XM_006528806.3 → XP_006528869.1  adhesion G-protein coupled receptor G2 isoform X1

    UniProtKB/TrEMBL
    A2AHQ2
    Conserved Domains (4) summary
    PRK14948
    Location:368 → 559
    PRK14948; DNA polymerase III subunit gamma/tau
    cd15444
    Location:700 → 969
    7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:637 → 687
    GPS; GPCR proteolysis site, GPS, motif
    pfam03154
    Location:288 → 423
    Atrophin-1; Atrophin-1 family

  18. XM_036161936.1 → XP_036017829.1  adhesion G-protein coupled receptor G2 isoform X15

    UniProtKB/TrEMBL
    A2AHQ2
    Conserved Domains (4) summary
    cd15444
    Location:700 → 969
    7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:637 → 687
    GPS; GPCR proteolysis site, GPS, motif
    pfam03154
    Location:289 → 562
    Atrophin-1; Atrophin-1 family
    NF033913
    Location:315 → 435
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  19. XM_036161940.1 → XP_036017833.1  adhesion G-protein coupled receptor G2 isoform X19

    UniProtKB/TrEMBL
    A2AHQ2
    Conserved Domains (4) summary
    cd15444
    Location:693 → 962
    7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:637 → 680
    GPS; GPCR proteolysis site, GPS, motif
    pfam03154
    Location:289 → 562
    Atrophin-1; Atrophin-1 family
    NF033913
    Location:315 → 435
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  20. XM_006528808.4 → XP_006528871.1  adhesion G-protein coupled receptor G2 isoform X3

    UniProtKB/TrEMBL
    A2AHQ2
    Conserved Domains (4) summary
    PRK14948
    Location:368 → 559
    PRK14948; DNA polymerase III subunit gamma/tau
    cd15444
    Location:693 → 962
    7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:637 → 680
    GPS; GPCR proteolysis site, GPS, motif
    pfam03154
    Location:288 → 423
    Atrophin-1; Atrophin-1 family

  21. XM_006528810.4 → XP_006528873.1  adhesion G-protein coupled receptor G2 isoform X5

    UniProtKB/TrEMBL
    A2AHQ2
    Conserved Domains (4) summary
    PRK14948
    Location:354 → 545
    PRK14948; DNA polymerase III subunit gamma/tau
    cd15444
    Location:686 → 955
    7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:623 → 673
    GPS; GPCR proteolysis site, GPS, motif
    pfam03154
    Location:274 → 409
    Atrophin-1; Atrophin-1 family

  22. XM_006528812.4 → XP_006528875.1  adhesion G-protein coupled receptor G2 isoform X7

    UniProtKB/TrEMBL
    A2AHQ2
    Conserved Domains (4) summary
    PRK14948
    Location:354 → 545
    PRK14948; DNA polymerase III subunit gamma/tau
    cd15444
    Location:679 → 948
    7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:623 → 666
    GPS; GPCR proteolysis site, GPS, motif
    pfam03154
    Location:274 → 409
    Atrophin-1; Atrophin-1 family

  23. XM_006528807.4 → XP_006528870.1  adhesion G-protein coupled receptor G2 isoform X2

    UniProtKB/TrEMBL
    A2AHQ2
    Conserved Domains (4) summary
    PRK14948
    Location:365 → 556
    PRK14948; DNA polymerase III subunit gamma/tau
    cd15444
    Location:697 → 966
    7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:634 → 684
    GPS; GPCR proteolysis site, GPS, motif
    pfam03154
    Location:285 → 420
    Atrophin-1; Atrophin-1 family

  24. XM_006528809.4 → XP_006528872.1  adhesion G-protein coupled receptor G2 isoform X4

    UniProtKB/TrEMBL
    A2AHQ2
    Conserved Domains (4) summary
    PRK14948
    Location:365 → 556
    PRK14948; DNA polymerase III subunit gamma/tau
    cd15444
    Location:690 → 959
    7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:634 → 677
    GPS; GPCR proteolysis site, GPS, motif
    pfam03154
    Location:285 → 420
    Atrophin-1; Atrophin-1 family

  25. XM_006528811.4 → XP_006528874.1  adhesion G-protein coupled receptor G2 isoform X6

    UniProtKB/TrEMBL
    A2AHQ2
    Conserved Domains (4) summary
    PRK14948
    Location:351 → 542
    PRK14948; DNA polymerase III subunit gamma/tau
    cd15444
    Location:683 → 952
    7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:620 → 670
    GPS; GPCR proteolysis site, GPS, motif
    pfam03154
    Location:271 → 406
    Atrophin-1; Atrophin-1 family

  26. XM_006528813.4 → XP_006528876.1  adhesion G-protein coupled receptor G2 isoform X8

    UniProtKB/TrEMBL
    A2AHQ2
    Conserved Domains (4) summary
    PRK14948
    Location:351 → 542
    PRK14948; DNA polymerase III subunit gamma/tau
    cd15444
    Location:676 → 945
    7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:620 → 663
    GPS; GPCR proteolysis site, GPS, motif
    pfam03154
    Location:271 → 406
    Atrophin-1; Atrophin-1 family

  27. XM_006528814.4 → XP_006528877.1  adhesion G-protein coupled receptor G2 isoform X9

    UniProtKB/TrEMBL
    A2AHQ2
    Conserved Domains (4) summary
    PRK14948
    Location:341 → 532
    PRK14948; DNA polymerase III subunit gamma/tau
    cd15444
    Location:673 → 942
    7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:610 → 660
    GPS; GPCR proteolysis site, GPS, motif
    pfam03154
    Location:261 → 396
    Atrophin-1; Atrophin-1 family

  28. XM_006528816.4 → XP_006528879.1  adhesion G-protein coupled receptor G2 isoform X11

    UniProtKB/TrEMBL
    A2AHQ2
    Conserved Domains (4) summary
    PRK14948
    Location:341 → 532
    PRK14948; DNA polymerase III subunit gamma/tau
    cd15444
    Location:666 → 935
    7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:610 → 653
    GPS; GPCR proteolysis site, GPS, motif
    pfam03154
    Location:261 → 396
    Atrophin-1; Atrophin-1 family

  29. XM_006528819.4 → XP_006528882.1  adhesion G-protein coupled receptor G2 isoform X14

    UniProtKB/TrEMBL
    A2AHQ2
    Conserved Domains (4) summary
    PRK14948
    Location:327 → 518
    PRK14948; DNA polymerase III subunit gamma/tau
    cd15444
    Location:659 → 928
    7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:596 → 646
    GPS; GPCR proteolysis site, GPS, motif
    pfam03154
    Location:247 → 382
    Atrophin-1; Atrophin-1 family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CJ12.1 GenPept UniProtKB/Swiss-Prot:Q8CJ12

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