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Zc3h12d zinc finger CCCH type containing 12D [ Mus musculus (house mouse) ]

Gene ID: 237256, updated on 21-Apr-2024

Summary

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Official Symbol
Zc3h12dprovided by MGI
Official Full Name
zinc finger CCCH type containing 12Dprovided by MGI
Primary source
MGI:MGI:3045313
See related
Ensembl:ENSMUSG00000039981 AllianceGenome:MGI:3045313
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TFL; D730019B10Rik
Summary
Predicted to enable endoribonuclease activity and mRNA binding activity. Involved in 3'-UTR-mediated mRNA destabilization. Acts upstream of or within mRNA catabolic process and negative regulation of T cell proliferation. Predicted to be located in P-body and nucleoplasm. Predicted to be active in cytoplasmic ribonucleoprotein granule and nucleus. Orthologous to human ZC3H12D (zinc finger CCCH-type containing 12D). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 9.8), duodenum adult (RPKM 3.6) and 9 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 A1; 10 2.44 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (7708087..7746161)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (7832323..7870397)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9338 Neighboring gene glycoprotein integral membrane 1 Neighboring gene STARR-positive B cell enhancer mm9_chr10:7529819-7530120 Neighboring gene peptidylprolyl isomerase (cyclophilin)-like 4 Neighboring gene STARR-positive B cell enhancer ABC_E5118 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:7559346-7559529 Neighboring gene microRNA 5104 Neighboring gene predicted gene, 24726 Neighboring gene STARR-seq mESC enhancer starr_25692 Neighboring gene STARR-seq mESC enhancer starr_25693 Neighboring gene TGF-beta activated kinase 1/MAP3K7 binding protein 2 Neighboring gene STARR-seq mESC enhancer starr_25694 Neighboring gene predicted gene, 30820

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tfl deletion induces extraordinary Cxcl13 secretion and cachexia in VavP-Bcl2 transgenic mice. Minagawa K, et al. Front Immunol, 2023. PMID 37304286, Free PMC Article
  2. ZC3H12D attenuated inflammation responses by reducing mRNA stability of proinflammatory genes. Zhang H, et al. Mol Immunol, 2015 Oct. PMID 26059755
  3. The putative tumor suppressor Zc3h12d modulates toll-like receptor signaling in macrophages. Huang S, et al. Cell Signal, 2012 Feb. PMID 22036805, Free PMC Article
  4. Posttranscriptional modulation of cytokine production in T cells for the regulation of excessive inflammation by TFL. Minagawa K, et al. J Immunol, 2014 Feb 15. PMID 24415781
  5. Genome-wide survey and expression profiling of CCCH-zinc finger family reveals a functional module in macrophage activation. Liang J, et al. PLoS One, 2008 Aug 6. PMID 18682727, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tfl deletion induces extraordinary Cxcl13 secretion and cachexia in VavP-Bcl2 transgenic mice.
    Title: Tfl deletion induces extraordinary Cxcl13 secretion and cachexia in VavP-Bcl2 transgenic mice.
  2. The data indicated that ZC3H12D could suppress both the initial inflammation storm and chronic inflammation by targeting the mRNA of cytokines as well as NF-kappaB and c-fos.
    Title: ZC3H12D attenuated inflammation responses by reducing mRNA stability of proinflammatory genes.
  3. TFL (Zc3h12d) may play an important role in attenuating local inflammation by suppressing the infiltration of Th17 cells in the central nervous system during the resolution phase of experimental autoimmune encephalitis.
    Title: Posttranscriptional modulation of cytokine production in T cells for the regulation of excessive inflammation by TFL.
  4. Zc3h12d is a novel negative feedback regulator of TLR signaling and macrophage activation and thus may play a role in host immunity and inflammatory diseases.
    Title: The putative tumor suppressor Zc3h12d modulates toll-like receptor signaling in macrophages.
  5. MCPIP1, 2, 3, and 4, encoded by four genes, Zc3h12a, Zc3h12b, Zc3h12c, and Zc3h12d, respectively, regulates macrophage activation.
    Title: A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 3'-UTR-mediated mRNA destabilization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 3'-UTR-mediated mRNA destabilization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in P-body ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasmic ribonucleoprotein granule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
probable ribonuclease ZC3H12D
Names
transformed follicular lymphoma homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172785.3 → NP_766373.2  probable ribonuclease ZC3H12D

    See identical proteins and their annotated locations for NP_766373.2

    Status: VALIDATED

    Source sequence(s)
    AC092856, AK052806, BB661745
    Consensus CDS
    CCDS48496.1
    UniProtKB/Swiss-Prot
    A4FU74, Q8BIY3
    UniProtKB/TrEMBL
    E9QNR7
    Related
    ENSMUSP00000040217.5, ENSMUST00000039484.6
    Conserved Domains (3) summary
    PHA03247
    Location:233 → 516
    PHA03247; large tegument protein UL36; Provisional
    cd18729
    Location:95 → 225
    PIN_Zc3h12-like; PRORP-like PIN domain of ribonuclease Zc3h12a and related proteins
    pfam18039
    Location:3 → 44
    UBA_6; UBA-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    7708087..7746161
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512724.2 → XP_006512787.1  probable ribonuclease ZC3H12D isoform X1

    See identical proteins and their annotated locations for XP_006512787.1

    UniProtKB/Swiss-Prot
    A4FU74, Q8BIY3
    UniProtKB/TrEMBL
    E9QNR7
    Conserved Domains (3) summary
    PHA03247
    Location:233 → 516
    PHA03247; large tegument protein UL36; Provisional
    cd18729
    Location:95 → 225
    PIN_Zc3h12-like; PRORP-like PIN domain of ribonuclease Zc3h12a and related proteins
    pfam18039
    Location:3 → 44
    UBA_6; UBA-like domain

  2. XM_006512723.4 → XP_006512786.1  probable ribonuclease ZC3H12D isoform X1

    See identical proteins and their annotated locations for XP_006512786.1

    UniProtKB/Swiss-Prot
    A4FU74, Q8BIY3
    UniProtKB/TrEMBL
    E9QNR7
    Conserved Domains (3) summary
    PHA03247
    Location:233 → 516
    PHA03247; large tegument protein UL36; Provisional
    cd18729
    Location:95 → 225
    PIN_Zc3h12-like; PRORP-like PIN domain of ribonuclease Zc3h12a and related proteins
    pfam18039
    Location:3 → 44
    UBA_6; UBA-like domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BIY3.2 GenPept UniProtKB/Swiss-Prot:Q8BIY3

Gene LinkOut

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