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TMEM245 transmembrane protein 245 [ Homo sapiens (human) ]

Gene ID: 23731, updated on 5-Mar-2024

Summary

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Official Symbol
TMEM245provided by HGNC
Official Full Name
transmembrane protein 245provided by HGNC
Primary source
HGNC:HGNC:1363
See related
Ensembl:ENSG00000106771 MIM:620252; AllianceGenome:HGNC:1363
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CG2; CG-2; C9orf5
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 48.4), adrenal (RPKM 29.0) and 25 other tissues See more
Orthologs
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Genomic context

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See TMEM245 in Genome Data Viewer
Location:
9q31.3
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (109015135..109119947, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (121184210..121289014, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (111777415..111882227, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20160 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:111713956-111715155 Neighboring gene actin binding transcription modulator Neighboring gene catenin alpha like 1 Neighboring gene uncharacterized LOC105376216 Neighboring gene RNA, 5.8S ribosomal pseudogene 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:111774967-111775470 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:111798078-111799277 Neighboring gene microRNA 32 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20162 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28758 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20163 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20164 Neighboring gene ferric chelate reductase 1 like Neighboring gene Sharpr-MPRA regulatory region 1434 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:111947797-111948296 Neighboring gene erythrocyte membrane protein band 4.1 like 4B Neighboring gene RNA, U6 small nuclear 984, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Cloning, genomic organization and expression of a putative human transmembrane protein related to the Caenorhabditis elegans M01F1.4 gene. Chadwick BP, et al. Gene, 1999 Nov 15. PMID 10564813
  2. BCL9 and C9orf5 are associated with negative symptoms in schizophrenia: meta-analysis of two genome-wide association studies. Xu C, et al. PLoS One, 2013. PMID 23382809, Free PMC Article
  3. Whole genome association scan for genetic polymorphisms influencing information processing speed. Luciano M, et al. Biol Psychol, 2011 Mar. PMID 21130836, Free PMC Article
  4. Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. Perry JR, et al. Nature, 2014 Oct 2. PMID 25231870, Free PMC Article
  5. DNA sequence and analysis of human chromosome 9. Humphray SJ, et al. Nature, 2004 May 27. PMID 15164053, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. we detected five SNPs in the first two genes/loci - BCL9 and C9orf5 - strongly associated with negative symptoms of schizophrenia
    Title: BCL9 and C9orf5 are associated with negative symptoms in schizophrenia: meta-analysis of two genome-wide association studies.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
BCL9 and C9orf5 are associated with negative symptoms in schizophrenia: meta-analysis of two genome-wide association studies.
EBI GWAS Catalog
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
EBI GWAS Catalog
Whole genome association scan for genetic polymorphisms influencing information processing speed.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ23668, FLJ33224

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
transmembrane protein 245
Names
protein CG-2
transmembrane protein C9orf5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032012.4 → NP_114401.2  transmembrane protein 245

    See identical proteins and their annotated locations for NP_114401.2

    Status: VALIDATED

    Source sequence(s)
    AL354797, AL358815, AL556162, BC014248, BE675782, BM817899, BP351493, BP360669, DC341553
    Consensus CDS
    CCDS43858.1
    UniProtKB/Swiss-Prot
    B4DSW7, Q5JTQ5, Q5SS43, Q6ZME3, Q8NDJ5, Q96CG6, Q9H330
    Related
    ENSP00000363714.3, ENST00000374586.8
    Conserved Domains (1) summary
    cl00465
    Location:594 → 840
    AI-2E_transport; AI-2E family transporter

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    109015135..109119947 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047423140.1 → XP_047279096.1  transmembrane protein 245 isoform X7

  2. XM_011518449.3 → XP_011516751.1  transmembrane protein 245 isoform X4

    Conserved Domains (1) summary
    cl00465
    Location:555 → 801
    UPF0118; Domain of unknown function DUF20

  3. XM_047423142.1 → XP_047279098.1  transmembrane protein 245 isoform X10

  4. XM_017014572.2 → XP_016870061.1  transmembrane protein 245 isoform X9

  5. XM_011518452.3 → XP_011516754.1  transmembrane protein 245 isoform X8

    Conserved Domains (1) summary
    cl00465
    Location:516 → 762
    UPF0118; Domain of unknown function DUF20

  6. XM_047423139.1 → XP_047279095.1  transmembrane protein 245 isoform X6

  7. XM_017014571.2 → XP_016870060.1  transmembrane protein 245 isoform X3

  8. XM_011518446.3 → XP_011516748.1  transmembrane protein 245 isoform X1

    Conserved Domains (1) summary
    cl00465
    Location:593 → 839
    UPF0118; Domain of unknown function DUF20

  9. XM_011518451.2 → XP_011516753.1  transmembrane protein 245 isoform X5

    Conserved Domains (1) summary
    cl00465
    Location:551 → 797
    UPF0118; Domain of unknown function DUF20

  10. XM_011518447.2 → XP_011516749.1  transmembrane protein 245 isoform X2

    UniProtKB/TrEMBL
    H7C0G1
    Related
    ENSP00000394798.3, ENST00000413712.7
    Conserved Domains (1) summary
    cl00465
    Location:586 → 832
    UPF0118; Domain of unknown function DUF20

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    121184210..121289014 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054362596.1 → XP_054218571.1  transmembrane protein 245 isoform X7

  2. XM_054362593.1 → XP_054218568.1  transmembrane protein 245 isoform X4

  3. XM_054362599.1 → XP_054218574.1  transmembrane protein 245 isoform X10

  4. XM_054362598.1 → XP_054218573.1  transmembrane protein 245 isoform X9

  5. XM_054362597.1 → XP_054218572.1  transmembrane protein 245 isoform X8

  6. XM_054362595.1 → XP_054218570.1  transmembrane protein 245 isoform X6

  7. XM_054362592.1 → XP_054218567.1  transmembrane protein 245 isoform X3

  8. XM_054362590.1 → XP_054218565.1  transmembrane protein 245 isoform X1

  9. XM_054362594.1 → XP_054218569.1  transmembrane protein 245 isoform X5

  10. XM_054362591.1 → XP_054218566.1  transmembrane protein 245 isoform X2

    UniProtKB/TrEMBL
    H7C0G1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001099734.1: Suppressed sequence

    Description
    NM_001099734.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H330.3 GenPept UniProtKB/Swiss-Prot:Q9H330

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