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Zfp454 zinc finger protein 454 [ Mus musculus (house mouse) ]

Gene ID: 237758, updated on 5-Mar-2024

Summary

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Official Symbol
Zfp454provided by MGI
Official Full Name
zinc finger protein 454provided by MGI
Primary source
MGI:MGI:2679253
See related
Ensembl:ENSMUSG00000048728 AllianceGenome:MGI:2679253
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B230342N19
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in bladder; male associated reproductive structure; testis; ureter; and urethra of male. Orthologous to human ZNF454 (zinc finger protein 454). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 2.3), CNS E14 (RPKM 2.1) and 11 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp454 in Genome Data Viewer
Location:
11 B1.3; 11 30.94 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (50763545..50778463, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (50872718..50887634, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 879 Neighboring gene STARR-positive B cell enhancer ABC_E6979 Neighboring gene glutamate receptor, metabotropic 6 Neighboring gene STARR-seq mESC enhancer starr_29409 Neighboring gene zinc finger protein 2 Neighboring gene zinc finger protein 354B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  2. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC57560

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 454

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359531.1 → NP_001346460.1  zinc finger protein 454 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, uses an alternate start codon and lacks three coding exons, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK046117, BC049793
    UniProtKB/TrEMBL
    Q8BIK0
    Conserved Domains (2) summary
    COG5048
    Location:135 → 447
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:259 → 279
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001382449.1 → NP_001369378.1  zinc finger protein 454 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL627215
    Conserved Domains (3) summary
    smart00349
    Location:14 → 66
    KRAB; krueppel associated box
    COG5048
    Location:196 → 531
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:343 → 363
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_001382450.1 → NP_001369379.1  zinc finger protein 454 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL627215
    Conserved Domains (3) summary
    smart00349
    Location:14 → 66
    KRAB; krueppel associated box
    COG5048
    Location:196 → 531
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:343 → 363
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. NM_001382451.1 → NP_001369380.1  zinc finger protein 454 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL627215
    UniProtKB/TrEMBL
    Q80Y34
    Related
    ENSMUSP00000129125.2, ENSMUST00000163301.8
    Conserved Domains (3) summary
    smart00349
    Location:14 → 67
    KRAB; krueppel associated box
    COG5048
    Location:197 → 532
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:344 → 364
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. NM_001382452.1 → NP_001369381.1  zinc finger protein 454 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL627215
    Conserved Domains (2) summary
    COG5048
    Location:163 → 498
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:310 → 330
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. NM_001382453.1 → NP_001369382.1  zinc finger protein 454 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL627215
    Conserved Domains (2) summary
    COG5048
    Location:163 → 498
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:310 → 330
    ZF_C2H2; C2H2 Zn finger [structural motif]

  7. NM_001382454.1 → NP_001369383.1  zinc finger protein 454 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL627215
    Conserved Domains (2) summary
    COG5048
    Location:133 → 468
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:280 → 300
    ZF_C2H2; C2H2 Zn finger [structural motif]

  8. NM_001382455.1 → NP_001369384.1  zinc finger protein 454 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL627215
    Conserved Domains (2) summary
    COG5048
    Location:133 → 468
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:280 → 300
    ZF_C2H2; C2H2 Zn finger [structural motif]

  9. NM_001382456.1 → NP_001369385.1  zinc finger protein 454 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL627215
    Conserved Domains (2) summary
    COG5048
    Location:142 → 477
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:289 → 309
    ZF_C2H2; C2H2 Zn finger [structural motif]

  10. NM_001382457.1 → NP_001369386.1  zinc finger protein 454 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL627215
    Conserved Domains (2) summary
    COG5048
    Location:164 → 499
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:311 → 331
    ZF_C2H2; C2H2 Zn finger [structural motif]

  11. NM_172794.3 → NP_766382.2  zinc finger protein 454 isoform 1

    See identical proteins and their annotated locations for NP_766382.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK046117, BC049793
    Consensus CDS
    CCDS24639.1
    UniProtKB/TrEMBL
    Q80Y34
    Related
    ENSMUSP00000061824.7, ENSMUST00000050595.13
    Conserved Domains (3) summary
    smart00349
    Location:14 → 67
    KRAB; krueppel associated box
    COG5048
    Location:197 → 532
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:344 → 364
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    50763545..50778463 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245962.2 → XP_030101822.1  zinc finger protein 454 isoform X1

    UniProtKB/TrEMBL
    Q8BIK0
    Conserved Domains (2) summary
    COG5048
    Location:135 → 447
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:259 → 279
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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