Coro1b coronin, actin binding protein 1B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Coro1bprovided by MGI
Official Full Name: coronin, actin binding protein 1Bprovided by MGI
Primary source: MGI:MGI:1345963
See related: Ensembl:ENSMUSG00000024835 AllianceGenome:MGI:1345963
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable Arp2/3 complex binding activity; actin filament binding activity; and identical protein binding activity. Predicted to be involved in several processes, including actin filament organization; cellular response to platelet-derived growth factor stimulus; and regulation of lamellipodium morphogenesis. Predicted to be located in several cellular components, including actin cytoskeleton; lamellipodium; and perinuclear region of cytoplasm. Is expressed in several structures, including brain; dorsal root ganglion; genitourinary system; liver; and spleen. Orthologous to human CORO1B (coronin 1B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in colon adult (RPKM 222.9), large intestine adult (RPKM 168.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 3.85 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (4198610..4204034)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (4148611..4154035)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Coro1B and Coro1C regulate lamellipodia dynamics and cell motility by tuning branched actin turnover.
Title: Coro1B and Coro1C regulate lamellipodia dynamics and cell motility by tuning branched actin turnover.
Cor1B, Cof1 and AIP1 work in concert through a temporally ordered pathway to induce highly efficient severing and disassembly of actin filaments.
Title: Single-molecule imaging of a three-component ordered actin disassembly mechanism.
Wt1 is a transcriptional activator of Coro1b gene.
Title: The Wilms' tumor suppressor Wt1 regulates Coronin 1B expression in the epicardium.
Suggest that phosphorylation of Coro1B and the subsequent reduced interaction with ARP2/3 complex participate in PDGF-induced VSMC migration, an important step in vascular lesion formation.
Title: Role of coronin 1B in PDGF-induced migration of vascular smooth muscle cells.
Differential regulation of mast cell degranulation versus cytokine secretion by the actin regulatory proteins Coronin1a and Coronin1b.
Title: Differential regulation of mast cell degranulation versus cytokine secretion by the actin regulatory proteins Coronin1a and Coronin1b.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Arp2/3 complex binding	ISO Inferred from Sequence Orthology more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables cytoskeletal protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in actin filament branching	ISO Inferred from Sequence Orthology more info
involved_in actin filament bundle assembly	ISO Inferred from Sequence Orthology more info
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cellular response to platelet-derived growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in endothelial cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Arp2/3 complex-mediated actin nucleation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lamellipodium morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smooth muscle cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lamellipodium morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in protein kinase C signaling	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cell leading edge	ISO Inferred from Sequence Orthology more info
involved_in ruffle organization	ISO Inferred from Sequence Orthology more info
involved_in wound healing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in actin filament	ISO Inferred from Sequence Orthology more info
located_in cell leading edge	ISO Inferred from Sequence Orthology more info
located_in cell periphery	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in stress fiber	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: coronin-1B

Names: coronin 1b; coronin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001412937.1 → NP_001399866.1 coronin-1B

Status: VALIDATED

Source sequence(s)

AC109138

UniProtKB/Swiss-Prot

Q3UEB1, Q9CVA2, Q9WUM3

UniProtKB/TrEMBL

A2RS22
NM_001412938.1 → NP_001399867.1 coronin-1B

Status: VALIDATED

Source sequence(s)

AC109138

UniProtKB/Swiss-Prot

Q3UEB1, Q9CVA2, Q9WUM3

UniProtKB/TrEMBL

A2RS22
NM_011778.3 → NP_035908.1 coronin-1B

See identical proteins and their annotated locations for NP_035908.1

Status: VALIDATED

Source sequence(s)

AC109138

Consensus CDS

CCDS29418.1

UniProtKB/Swiss-Prot

Q3UEB1, Q9CVA2, Q9WUM3

UniProtKB/TrEMBL

A2RS22

Related

ENSMUSP00000008893.9, ENSMUST00000008893.9

Conserved Domains (2) summary

sd00039
Location:38 → 80

7WD40; WD40 repeat [structural motif]

cl29593
Location:10 → 480

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

4198610..4204034

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036161585.1 → XP_036017478.1 coronin-1B isoform X2

Conserved Domains (2) summary

sd00039
Location:47 → 82

7WD40; WD40 repeat [structural motif]

cl29593
Location:18 → 347

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036161586.1 → XP_036017479.1 coronin-1B isoform X2

Conserved Domains (2) summary

sd00039
Location:47 → 82

7WD40; WD40 repeat [structural motif]

cl29593
Location:18 → 347

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036161587.1 → XP_036017480.1 coronin-1B isoform X2

Conserved Domains (2) summary

sd00039
Location:47 → 82

7WD40; WD40 repeat [structural motif]

cl29593
Location:18 → 347

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...