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Gpatch8 G patch domain containing 8 [ Mus musculus (house mouse) ]

Gene ID: 237943, updated on 21-Apr-2024

Summary

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Official Symbol
Gpatch8provided by MGI
Official Full Name
G patch domain containing 8provided by MGI
Primary source
MGI:MGI:1918667
See related
Ensembl:ENSMUSG00000034621 AllianceGenome:MGI:1918667
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fbm1; Gpatc8; mKIAA0553; 5430405G24Rik
Summary
Predicted to enable metal ion binding activity and nucleic acid binding activity. Predicted to be active in nucleus. Is expressed in brain; cerebellum; and forebrain. Orthologous to human GPATCH8 (G-patch domain containing 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 5.8), CNS E14 (RPKM 5.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 D- E1; 11 66.31 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (102366737..102447217, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (102475911..102556391, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 171, member A2 Neighboring gene STARR-positive B cell enhancer ABC_E7070 Neighboring gene integrin alpha 2b Neighboring gene cytochrome b-c1 complex subunit 10 pseudogene Neighboring gene STARR-seq mESC enhancer starr_30811 Neighboring gene STARR-positive B cell enhancer ABC_E10716 Neighboring gene midkine pseudogene 1 Neighboring gene predicted gene, 25337 Neighboring gene STARR-seq mESC enhancer starr_30813 Neighboring gene predicted gene 11627 Neighboring gene frizzled class receptor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular cloning of Fyn-associated molecules in the mouse central nervous system. Kai N, et al. J Neurosci Res, 1997 Jun 1. PMID 9185665
  2. Jade-1S phosphorylation induced by CK1α contributes to cell cycle progression. Borgal L, et al. Cell Cycle, 2016. PMID 26919559, Free PMC Article
  3. Tagging genes with cassette-exchange sites. Cobellis G, et al. Nucleic Acids Res, 2005 Mar 1. PMID 15741177, Free PMC Article
  4. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
  5. Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells. Zhang S, et al. Sci Data, 2018 Nov 20. PMID 30457570, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
G patch domain-containing protein 8
Names
Fyn-binding molecule 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159492.1 → NP_001152964.1  G patch domain-containing protein 8

    See identical proteins and their annotated locations for NP_001152964.1

    Status: VALIDATED

    Source sequence(s)
    AK142570, BC035255, BE980248, BY136728, CJ057626, CV555545
    Consensus CDS
    CCDS48944.1
    UniProtKB/Swiss-Prot
    A2A6A1, Q80TY1
    Related
    ENSMUSP00000120649.2, ENSMUST00000143842.2
    Conserved Domains (3) summary
    PRK03918
    Location:82 → 207
    PRK03918; DNA double-strand break repair ATPase Rad50
    pfam01585
    Location:40 → 82
    G-patch; G-patch domain
    pfam12171
    Location:136 → 163
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    102366737..102447217 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314538.2 → XP_017170027.1  G patch domain-containing protein 8 isoform X1

    Conserved Domains (2) summary
    PRK03918
    Location:4 → 129
    PRK03918; DNA double-strand break repair ATPase Rad50
    pfam12171
    Location:58 → 85
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

  2. XM_036156674.1 → XP_036012567.1  G patch domain-containing protein 8 isoform X2

  3. XM_006533251.2 → XP_006533314.1  G patch domain-containing protein 8 isoform X1

    See identical proteins and their annotated locations for XP_006533314.1

    Conserved Domains (2) summary
    PRK03918
    Location:4 → 129
    PRK03918; DNA double-strand break repair ATPase Rad50
    pfam12171
    Location:58 → 85
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

  4. XM_036156675.1 → XP_036012568.1  G patch domain-containing protein 8 isoform X2

  5. XM_036156667.1 → XP_036012560.1  G patch domain-containing protein 8 isoform X1

    Conserved Domains (2) summary
    PRK03918
    Location:4 → 129
    PRK03918; DNA double-strand break repair ATPase Rad50
    pfam12171
    Location:58 → 85
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

  6. XM_030245975.1 → XP_030101835.1  G patch domain-containing protein 8 isoform X1

    Conserved Domains (2) summary
    PRK03918
    Location:4 → 129
    PRK03918; DNA double-strand break repair ATPase Rad50
    pfam12171
    Location:58 → 85
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

  7. XM_017314541.2 → XP_017170030.1  G patch domain-containing protein 8 isoform X1

    Conserved Domains (2) summary
    PRK03918
    Location:4 → 129
    PRK03918; DNA double-strand break repair ATPase Rad50
    pfam12171
    Location:58 → 85
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

  8. XM_030245976.1 → XP_030101836.1  G patch domain-containing protein 8 isoform X2

  9. XM_036156665.1 → XP_036012558.1  G patch domain-containing protein 8 isoform X1

    Conserved Domains (2) summary
    PRK03918
    Location:4 → 129
    PRK03918; DNA double-strand break repair ATPase Rad50
    pfam12171
    Location:58 → 85
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

  10. XM_036156670.1 → XP_036012563.1  G patch domain-containing protein 8 isoform X1

    Conserved Domains (2) summary
    PRK03918
    Location:4 → 129
    PRK03918; DNA double-strand break repair ATPase Rad50
    pfam12171
    Location:58 → 85
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

  11. XM_036156666.1 → XP_036012559.1  G patch domain-containing protein 8 isoform X1

    Conserved Domains (2) summary
    PRK03918
    Location:4 → 129
    PRK03918; DNA double-strand break repair ATPase Rad50
    pfam12171
    Location:58 → 85
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

  12. XM_036156668.1 → XP_036012561.1  G patch domain-containing protein 8 isoform X1

    Conserved Domains (2) summary
    PRK03918
    Location:4 → 129
    PRK03918; DNA double-strand break repair ATPase Rad50
    pfam12171
    Location:58 → 85
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

  13. XM_036156672.1 → XP_036012565.1  G patch domain-containing protein 8 isoform X1

    Conserved Domains (2) summary
    PRK03918
    Location:4 → 129
    PRK03918; DNA double-strand break repair ATPase Rad50
    pfam12171
    Location:58 → 85
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

  14. XM_006533248.1 → XP_006533311.1  G patch domain-containing protein 8 isoform X1

    See identical proteins and their annotated locations for XP_006533311.1

    Conserved Domains (2) summary
    PRK03918
    Location:4 → 129
    PRK03918; DNA double-strand break repair ATPase Rad50
    pfam12171
    Location:58 → 85
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

  15. XM_017314544.2 → XP_017170033.1  G patch domain-containing protein 8 isoform X2

  16. XM_030245977.1 → XP_030101837.1  G patch domain-containing protein 8 isoform X2

  17. XM_036156673.1 → XP_036012566.1  G patch domain-containing protein 8 isoform X1

    Conserved Domains (2) summary
    PRK03918
    Location:4 → 129
    PRK03918; DNA double-strand break repair ATPase Rad50
    pfam12171
    Location:58 → 85
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

  18. XM_036156669.1 → XP_036012562.1  G patch domain-containing protein 8 isoform X1

    Conserved Domains (2) summary
    PRK03918
    Location:4 → 129
    PRK03918; DNA double-strand break repair ATPase Rad50
    pfam12171
    Location:58 → 85
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

  19. XM_036156671.1 → XP_036012564.1  G patch domain-containing protein 8 isoform X1

    Conserved Domains (2) summary
    PRK03918
    Location:4 → 129
    PRK03918; DNA double-strand break repair ATPase Rad50
    pfam12171
    Location:58 → 85
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2A6A1.1 GenPept UniProtKB/Swiss-Prot:A2A6A1

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