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Akt3 thymoma viral proto-oncogene 3 [ Mus musculus (house mouse) ]

Gene ID: 23797, updated on 5-Jan-2022

Summary

Official Symbol
Akt3provided by MGI
Official Full Name
thymoma viral proto-oncogene 3provided by MGI
Primary source
MGI:MGI:1345147
See related
Ensembl:ENSMUSG00000019699
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nmf350; AI851531; D930002M15Rik
Summary
Predicted to enable ATP binding activity; protein kinase C binding activity; and protein serine/threonine kinase activity. Involved in positive regulation of angiogenesis and positive regulation of artery morphogenesis. Acts upstream of or within several processes, including brain morphogenesis; positive regulation of TOR signaling; and positive regulation of cell size. Predicted to be located in plasma membrane. Is expressed in several structures, including genitourinary system; musculature; nervous system; retina; and skin. Human ortholog(s) of this gene implicated in colon cancer; glioblastoma; prostate adenocarcinoma; prostate cancer; and renal cell carcinoma. Orthologous to human AKT3 (AKT serine/threonine kinase 3). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Broad expression in CNS E18 (RPKM 12.2), CNS E14 (RPKM 10.5) and 22 other tissues See more
Orthologs
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Genomic context

See Akt3 in Genome Data Viewer
Location:
1; 1 H4
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (176847642..177091688, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (177020076..177261781, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (178952246..179178898, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene serologically defined colon cancer antigen 8 Neighboring gene high mobility group AT-hook 2, pseudogene 1 Neighboring gene predicted gene, 38158 Neighboring gene predicted gene 15423 Neighboring gene predicted gene, 36904 Neighboring gene zinc finger and BTB domain containing 18 Neighboring gene keratin 8 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase C binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within brain morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within homeostasis of number of cells within a tissue IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitochondrial genome maintenance ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cellular senescence ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of TOR signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of artery morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell size IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of sodium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
RAC-gamma serine/threonine-protein kinase
Names
PKB gamma
RAC-PK-gamma
protein kinase Akt-3
protein kinase B gamma
NP_035915.3
XP_006496881.1
XP_006496882.1
XP_011237107.1
XP_030109770.1
XP_030109777.1
XP_036020522.1
XP_036020523.1
XP_036020524.1
XP_036020525.1
XP_036020526.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011785.4NP_035915.3  RAC-gamma serine/threonine-protein kinase

    See identical proteins and their annotated locations for NP_035915.3

    Status: VALIDATED

    Source sequence(s)
    AC130843, AC163009, AK052953, BF455585, CD578931
    Consensus CDS
    CCDS35799.1
    UniProtKB/Swiss-Prot
    Q9WUA6
    UniProtKB/TrEMBL
    Q8C6X4
    Related
    ENSMUSP00000106790.3, ENSMUST00000111160.9
    Conserved Domains (2) summary
    cd01241
    Location:4110
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cd05593
    Location:132479
    STKc_PKB_gamma; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    176847642..177091688 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164629.1XP_036020522.1  RAC-gamma serine/threonine-protein kinase isoform X3

    Conserved Domains (2) summary
    cd01241
    Location:4110
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cl21453
    Location:132438
    PKc_like; Protein Kinases, catalytic domain
  2. XM_006496818.5XP_006496881.1  RAC-gamma serine/threonine-protein kinase isoform X1

    See identical proteins and their annotated locations for XP_006496881.1

    UniProtKB/Swiss-Prot
    Q9WUA6
    Related
    ENSMUSP00000106789.2, ENSMUST00000111159.2
    Conserved Domains (2) summary
    cd01241
    Location:4110
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cd05593
    Location:132479
    STKc_PKB_gamma; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3)
  3. XM_036164632.1XP_036020525.1  RAC-gamma serine/threonine-protein kinase isoform X7

    Conserved Domains (1) summary
    cl21453
    Location:46292
    PKc_like; Protein Kinases, catalytic domain
  4. XM_036164631.1XP_036020524.1  RAC-gamma serine/threonine-protein kinase isoform X6

    Conserved Domains (1) summary
    cd05593
    Location:16363
    STKc_PKB_gamma; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3)
  5. XM_036164630.1XP_036020523.1  RAC-gamma serine/threonine-protein kinase isoform X5

    Conserved Domains (2) summary
    cl17171
    Location:149
    PH-like; Pleckstrin homology-like domain
    cl21453
    Location:71377
    PKc_like; Protein Kinases, catalytic domain
  6. XM_030253917.2XP_030109777.1  RAC-gamma serine/threonine-protein kinase isoform X4

    Conserved Domains (2) summary
    cd05593
    Location:71418
    STKc_PKB_gamma; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3)
    cl17171
    Location:149
    PH-like; Pleckstrin homology-like domain
  7. XM_030253910.1XP_030109770.1  RAC-gamma serine/threonine-protein kinase isoform X1

    Conserved Domains (2) summary
    cd01241
    Location:4110
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cd05593
    Location:132479
    STKc_PKB_gamma; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3)
  8. XM_036164633.1XP_036020526.1  RAC-gamma serine/threonine-protein kinase isoform X7

    Conserved Domains (1) summary
    cl21453
    Location:46292
    PKc_like; Protein Kinases, catalytic domain
  9. XM_006496819.5XP_006496882.1  RAC-gamma serine/threonine-protein kinase isoform X1

    See identical proteins and their annotated locations for XP_006496882.1

    UniProtKB/Swiss-Prot
    Q9WUA6
    Conserved Domains (2) summary
    cd01241
    Location:4110
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cd05593
    Location:132479
    STKc_PKB_gamma; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3)
  10. XM_011238805.4XP_011237107.1  RAC-gamma serine/threonine-protein kinase isoform X2

    Conserved Domains (2) summary
    cd01241
    Location:4110
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cl21453
    Location:152417
    PKc_like; Protein Kinases, catalytic domain
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