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Amfr autocrine motility factor receptor [ Mus musculus (house mouse) ]

Gene ID: 23802, updated on 21-Apr-2024

Summary

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Official Symbol
Amfrprovided by MGI
Official Full Name
autocrine motility factor receptorprovided by MGI
Primary source
MGI:MGI:1345634
See related
Ensembl:ENSMUSG00000031751 AllianceGenome:MGI:1345634
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
gp78
Summary
Predicted to enable several functions, including BAT3 complex binding activity; chaperone binding activity; and ubiquitin-specific protease binding activity. Involved in negative regulation of canonical Wnt signaling pathway and regulation of SREBP signaling pathway. Predicted to be located in Golgi apparatus; endoplasmic reticulum membrane; and perinuclear region of cytoplasm. Predicted to be integral component of endoplasmic reticulum membrane and integral component of plasma membrane. Predicted to be part of Derlin-1 retrotranslocation complex and ubiquitin ligase complex. Predicted to be active in cytosol and endoplasmic reticulum. Is expressed in several structures, including central nervous system; genitourinary system; integumental system; liver; and retina nuclear layer. Orthologous to human AMFR (autocrine motility factor receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 95.7), liver adult (RPKM 63.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 C5; 8 45.96 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (94698216..94739301, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (93971588..94012640, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930488L21 gene Neighboring gene guanine nucleotide binding protein, alpha O Neighboring gene STARR-seq mESC enhancer starr_22343 Neighboring gene STARR-seq mESC enhancer starr_22344 Neighboring gene VISTA enhancer mm1458 Neighboring gene predicted gene, 53411 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:96561142-96561251 Neighboring gene nudix hydrolase 21 Neighboring gene 2-oxoglutarate and iron-dependent oxygenase domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ablation of gp78 in liver improves hyperlipidemia and insulin resistance by inhibiting SREBP to decrease lipid biosynthesis. Liu TF, et al. Cell Metab, 2012 Aug 8. PMID 22863805
  2. Autocrine motility factor receptor is involved in the process of learning and memory in the central nervous system. Yang Y, et al. Behav Brain Res, 2012 Apr 15. PMID 22313999
  3. Overexpression of autocrine motility factor receptor (AMFR) in NIH3T3 fibroblasts induces cell transformation. Onishi Y, et al. Clin Exp Metastasis, 2003. PMID 12650607
  4. Induction via Functional Protein Stabilization of Hepatic Cytochromes P450 upon gp78/Autocrine Motility Factor Receptor (AMFR) Ubiquitin E3-Ligase Genetic Ablation in Mice: Therapeutic and Toxicological Relevance. Kwon D, et al. Mol Pharmacol, 2019 Nov. PMID 31492698, Free PMC Article
  5. Expression patterns in mouse embryos of neuroleukin/glucose-6-phosphate isomerase and autocrine motility factor receptor. Repiso A, et al. Anat Histol Embryol, 2008 Oct. PMID 18537943

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Calmodulin regulates MGRN1-GP78 interaction mediated ubiquitin proteasomal degradation system.
    Title: Calmodulin regulates MGRN1-GP78 interaction mediated ubiquitin proteasomal degradation system.
  2. n the absence of both RNF145 and gp78, Hrd1, a third UBE2G2-dependent E3 ligase, partially regulates HMGCR activity. Our findings reveal a critical role for the sterol-responsive RNF145 in HMGCR regulation and elucidate the complexity of sterol-accelerated HMGCR degradation
    Title: The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1.
  3. the role of gp78 and cidec in hepatic steatosis, were investigated.
    Title: Role of glycoprotein 78 and cidec in hepatic steatosis.
  4. Gp78, an E3 ubiquitin ligase acts as a gatekeeper suppressing nonalcoholic steatohepatitis (NASH) and liver cancer.
    Title: Gp78, an E3 ubiquitin ligase acts as a gatekeeper suppressing nonalcoholic steatohepatitis (NASH) and liver cancer.
  5. role in innate immunity and STING signaling pathway
    Title: The E3 ubiquitin ligase AMFR and INSIG1 bridge the activation of TBK1 kinase by modifying the adaptor STING.
  6. The ubiquitin ligase gp78, known for its role in protein quality control, is critical for unglycosylated PrP ubiquitylation and degradation.
    Title: Ubiquitin ligase gp78 targets unglycosylated prion protein PrP for ubiquitylation and degradation.
  7. we consistently observe involvement of gp78 in Insig-1 degradation, we find no substantive evidence to support roles for either gp78 or TRC8 in the robust sterol-accelerated degradation of HMG-CoA reductase
    Title: Differential regulation of HMG-CoA reductase and Insig-1 by enzymes of the ubiquitin-proteasome system.
  8. Ablation of gp78 in liver improves hyperlipidemia and insulin resistance by inhibiting SREBP to decrease lipid biosynthesis.
    Title: Ablation of gp78 in liver improves hyperlipidemia and insulin resistance by inhibiting SREBP to decrease lipid biosynthesis.
  9. Palmitoylation of RING finger cysteines therefore regulates gp78 distribution to the peripheral ER
    Title: RING finger palmitoylation of the endoplasmic reticulum Gp78 E3 ubiquitin ligase.
  10. AMFR is involved in the process of learning and memory in the central nervous system.
    Title: Autocrine motility factor receptor is involved in the process of learning and memory in the central nervous system.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables BAT3 complex binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-specific protease binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-ubiquitin ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in endoplasmic reticulum unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum unfolded protein response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in non-canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K27-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of SREBP signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Derlin-1 retrotranslocation complex ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in growth cone ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase AMFR
Names
AMF receptor
RING-type E3 ubiquitin transferase AMFR
NP_001401199.1
NP_001401200.1
NP_001401201.1
NP_001401202.1
NP_001401203.1
NP_001401204.1
NP_001401205.1
NP_035917.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001414270.1 → NP_001401199.1  E3 ubiquitin-protein ligase AMFR isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC138118

  2. NM_001414271.1 → NP_001401200.1  E3 ubiquitin-protein ligase AMFR isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC138118

  3. NM_001414272.1 → NP_001401201.1  E3 ubiquitin-protein ligase AMFR isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC138118

  4. NM_001414273.1 → NP_001401202.1  E3 ubiquitin-protein ligase AMFR isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC138118

  5. NM_001414274.1 → NP_001401203.1  E3 ubiquitin-protein ligase AMFR isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC138118

  6. NM_001414275.1 → NP_001401204.1  E3 ubiquitin-protein ligase AMFR isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC138118

  7. NM_001414276.1 → NP_001401205.1  E3 ubiquitin-protein ligase AMFR isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC138118

  8. NM_011787.3 → NP_035917.2  E3 ubiquitin-protein ligase AMFR isoform 1

    See identical proteins and their annotated locations for NP_035917.2

    Status: VALIDATED

    Source sequence(s)
    AC138118
    Consensus CDS
    CCDS22533.1
    UniProtKB/Swiss-Prot
    Q8K008, Q99LH5, Q9R049
    UniProtKB/TrEMBL
    Q3TCI2, Q3U007
    Related
    ENSMUSP00000052258.7, ENSMUST00000053766.14
    Conserved Domains (3) summary
    COG5243
    Location:82 → 378
    HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
    cd14421
    Location:454 → 494
    CUE_AMFR; CUE domain found in autocrine motility factor receptor (AMFR) and similar proteins
    pfam13639
    Location:335 → 375
    zf-RING_2; Ring finger domain

RNA

  1. NR_182267.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC138118

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    94698216..94739301 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R049.2 GenPept UniProtKB/Swiss-Prot:Q9R049

Gene LinkOut

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