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Mideas mitotic deacetylase associated SANT domain protein [ Mus musculus (house mouse) ]

Gene ID: 238317, updated on 5-Mar-2024

Summary

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Official Symbol
Mideasprovided by MGI
Official Full Name
mitotic deacetylase associated SANT domain proteinprovided by MGI
Primary source
MGI:MGI:2685106
See related
Ensembl:ENSMUSG00000042507 AllianceGenome:MGI:2685106
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm260; Elmsan1; 9430029N19Rik; C130039O16Rik
Summary
Predicted to enable transcription corepressor activity. Predicted to be involved in histone deacetylation; negative regulation of transcription, DNA-templated; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be part of histone deacetylase complex and transcription regulator complex. Is expressed in brain; cerebral cortex; and telencephalon ventricular layer. Orthologous to human MIDEAS (mitotic deacetylase associated SANT domain protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen adult (RPKM 12.5), lung adult (RPKM 10.7) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Mideas in Genome Data Viewer
Location:
12 D1; 12 39.07 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (84195942..84265679, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (84149168..84218881, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene dynein, axonemal, light chain 1 Neighboring gene paraneoplastic antigen MA1 Neighboring gene predicted gene, 40476 Neighboring gene VISTA enhancer mm529 Neighboring gene STARR-positive B cell enhancer ABC_E4036 Neighboring gene STARR-positive B cell enhancer ABC_E8492 Neighboring gene STARR-seq mESC enhancer starr_32733 Neighboring gene predicted gene, 31513 Neighboring gene predicted gene, 51953 Neighboring gene predicted gene, 46319 Neighboring gene STARR-seq mESC enhancer starr_32734 Neighboring gene ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10765 Neighboring gene prostaglandin reductase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure. Turnbull RE, et al. Nat Commun, 2020 Jun 26. PMID 32591534, Free PMC Article
  2. Homologs of genes expressed in Caenorhabditis elegans GABAergic neurons are also found in the developing mouse forebrain. Hammock EA, et al. Neural Dev, 2010 Dec 1. PMID 21122108, Free PMC Article
  3. A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal. Gagliardi A, et al. EMBO J, 2013 Aug 14. PMID 23892456, Free PMC Article
  4. An Oct4-centered protein interaction network in embryonic stem cells. van den Berg DLC, et al. Cell Stem Cell, 2010 Apr 2. PMID 20362541, Free PMC Article
  5. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of histone deacetylase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
mitotic deacetylase-associated SANT domain protein
Names
ELM2 and Myb/SANT-like domain containing 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163501.1 → NP_001156973.1  mitotic deacetylase-associated SANT domain protein

    See identical proteins and their annotated locations for NP_001156973.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant differs in the 5' UTR, compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC125071, AC159649
    Consensus CDS
    CCDS49109.1
    UniProtKB/TrEMBL
    A0A1Y7VP67, E9Q2I4
    Related
    ENSMUSP00000048120.7, ENSMUST00000046266.13
    Conserved Domains (3) summary
    PTZ00121
    Location:887 → 1068
    PTZ00121; MAEBL; Provisional
    pfam01448
    Location:715 → 770
    ELM2; ELM2 domain
    cl21498
    Location:824 → 868
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

  2. NM_001163502.1 → NP_001156974.1  mitotic deacetylase-associated SANT domain protein

    See identical proteins and their annotated locations for NP_001156974.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC125071
    Consensus CDS
    CCDS49109.1
    UniProtKB/TrEMBL
    A0A1Y7VP67, E9Q2I4
    Related
    ENSMUSP00000105923.2, ENSMUST00000110294.2
    Conserved Domains (3) summary
    PTZ00121
    Location:887 → 1068
    PTZ00121; MAEBL; Provisional
    pfam01448
    Location:715 → 770
    ELM2; ELM2 domain
    cl21498
    Location:824 → 868
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    84195942..84265679 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157404.1 → XP_036013297.1  mitotic deacetylase-associated SANT domain protein isoform X1

    UniProtKB/TrEMBL
    A0A1Y7VP67
    Conserved Domains (2) summary
    pfam01448
    Location:715 → 770
    ELM2; ELM2 domain
    cl21498
    Location:824 → 868
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
Nucleotide Protein Strain
Heading Accession and Version

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