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Slc24a4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 [ Mus musculus (house mouse) ]

Gene ID: 238384, updated on 20-Jul-2021

Summary

Official Symbol
Slc24a4provided by MGI
Official Full Name
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4provided by MGI
Primary source
MGI:MGI:2447362
See related
Ensembl:ENSMUSG00000041771
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NCKX; NCKX4; AW492432; A930002M03Rik
Expression
Biased expression in lung adult (RPKM 8.7), cortex adult (RPKM 5.6) and 8 other tissues See more
Orthologs
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Genomic context

See Slc24a4 in Genome Data Viewer
Location:
12; 12 E
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (102094986..102233392)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (102128727..102267133)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (103367629..103504959)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene ataxin 3 Neighboring gene NADH:ubiquinone oxidoreductase subunit B1 Neighboring gene cleavage and polyadenylation specific factor 2 Neighboring gene U3B small nuclear RNA pseudogene 3 Neighboring gene predicted gene, 25203 Neighboring gene Ras and Rab interactor 3 Neighboring gene legumain

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
 
enables calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium, potassium:sodium antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium, potassium:sodium antiporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium, potassium:sodium antiporter activity ISA
Inferred from Sequence Alignment
more info
PubMed 
enables calcium, potassium:sodium antiporter activity ISO
Inferred from Sequence Orthology
more info
 
enables calcium-dependent protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables calcium:sodium antiporter activity ISA
Inferred from Sequence Alignment
more info
PubMed 
enables calmodulin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in amelogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium ion export across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium ion import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in calcium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within calcium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cellular calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to high light intensity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cone photoresponse recovery IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in detection of chemical stimulus involved in sensory perception of smell IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of drinking behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in membrane repolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of calcium-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of olfactory nerve maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of phototransduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within potassium ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of regulation of G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of regulation of eating behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of regulation of signaling receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of response to melanocyte-stimulating hormone IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to odorant IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in sensory perception of smell IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in sensory perception of smell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sodium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cone photoreceptor outer segment IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of plasma membrane IC
Inferred by Curator
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
sodium/potassium/calcium exchanger 4
Names
K-dependent Na/Ca exchanger NCKX4
Na(+)/K(+)/Ca(2+)-exchange protein 4
solute carrier family 24 member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362345.1NP_001349274.1  sodium/potassium/calcium exchanger 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC130838, AC139330
    Related
    ENSMUSP00000125012.2, ENSMUST00000161325.2
    Conserved Domains (1) summary
    cl27511
    Location:80587
    Na_Ca_ex; Sodium/calcium exchanger protein
  2. NM_172152.3NP_742164.2  sodium/potassium/calcium exchanger 4 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC130838, AC139330
    Consensus CDS
    CCDS26117.2
    Related
    ENSMUSP00000078030.6, ENSMUST00000079020.12
    Conserved Domains (1) summary
    cl27511
    Location:80606
    Na_Ca_ex; Sodium/calcium exchanger protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    102094986..102233392
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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