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Mgll monoglyceride lipase [ Mus musculus (house mouse) ]

Gene ID: 23945, updated on 28-Jun-2021

Summary

Official Symbol
Mgllprovided by MGI
Official Full Name
monoglyceride lipaseprovided by MGI
Primary source
MGI:MGI:1346042
See related
Ensembl:ENSMUSG00000033174
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ma; Mgl; Magl; AA589436
Summary
This gene encodes a monoglyceride lipase, which catalyzes the hydrolysis of monoglycerides into fatty acids and glycerol. This enzyme is also thought to hydrolyze the endocannabinoid 2-arachidonoylglycerol. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]
Expression
Biased expression in subcutaneous fat pad adult (RPKM 221.3), genital fat pad adult (RPKM 144.9) and 14 other tissues See more
Orthologs
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Genomic context

See Mgll in Genome Data Viewer
Location:
6; 6 D1
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (88701381..88805342)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (88724412..88828360)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (88674406..88778354)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene Sec61 alpha 1 subunit (S. cerevisiae) Neighboring gene kelch repeat and BTB (POZ) domain containing 12 Neighboring gene predicted gene, 26588 Neighboring gene predicted gene 15612 Neighboring gene ankyrin repeat and BTB (POZ) domain containing 1 Neighboring gene podocalyxin-like 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acylglycerol lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables acylglycerol lipase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables acylglycerol lipase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables acylglycerol lipase activity ISO
Inferred from Sequence Orthology
more info
 
enables carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity ISO
Inferred from Sequence Orthology
more info
 
enables lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in acylglycerol catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in acylglycerol catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in acylglycerol catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in arachidonic acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within long-term synaptic depression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in monoacylglycerol catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in monoacylglycerol catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of axon extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of endocannabinoid signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in extrinsic component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 
located_in varicosity IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
monoglyceride lipase
Names
monoacylglycerol lipase
NP_001159721.1
NP_001159722.1
NP_001159723.1
NP_035974.1
XP_036021993.1
XP_036021994.1
XP_036021995.1
XP_036021996.1
XP_036021997.1
XP_036021998.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166249.1NP_001159721.1  monoglyceride lipase isoform c

    See identical proteins and their annotated locations for NP_001159721.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at a downstream start codon, and uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AA822246, AK131645, AK136867, AK148395, BY273849, CX565913
    Consensus CDS
    CCDS51844.1
    UniProtKB/Swiss-Prot
    O35678
    UniProtKB/TrEMBL
    Q3UFN1
    Related
    ENSMUSP00000109212.2, ENSMUST00000113582.8
    Conserved Domains (2) summary
    pfam12146
    Location:41230
    Hydrolase_4; Serine aminopeptidase, S33
    cl21494
    Location:22249
    Abhydrolase; alpha/beta hydrolases
  2. NM_001166250.1NP_001159722.1  monoglyceride lipase isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (d), which does not have in vivo support, has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC153860, AK006949, BY255454, BY706980
    UniProtKB/Swiss-Prot
    O35678
    Related
    ENSMUSP00000145068.2, ENSMUST00000150180.4
    Conserved Domains (1) summary
    cl21494
    Location:3893
    Abhydrolase; alpha/beta hydrolases
  3. NM_001166251.1NP_001159723.1  monoglyceride lipase isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AA822246, AC153860, AK006949, AK131645, AK136867, BY255454, BY706980, CX565913
    Consensus CDS
    CCDS51843.1
    UniProtKB/Swiss-Prot
    O35678
    UniProtKB/TrEMBL
    E9Q3B9
    Related
    ENSMUSP00000127374.2, ENSMUST00000163271.8
    Conserved Domains (2) summary
    pfam12146
    Location:57291
    Hydrolase_4; Serine aminopeptidase, S33
    cl21494
    Location:38310
    Abhydrolase; alpha/beta hydrolases
  4. NM_011844.4NP_035974.1  monoglyceride lipase isoform b

    See identical proteins and their annotated locations for NP_035974.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AA822246, AK131645, AK136867, BY273849, CX565913
    Consensus CDS
    CCDS20338.1
    UniProtKB/Swiss-Prot
    O35678
    Related
    ENSMUSP00000109215.3, ENSMUST00000113585.9
    Conserved Domains (2) summary
    pfam12146
    Location:41275
    Hydrolase_4; Serine aminopeptidase, S33
    cl21494
    Location:22294
    Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    88701381..88805342
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036166101.1XP_036021994.1  monoglyceride lipase isoform X2

    Related
    ENSMUSP00000109211.2, ENSMUST00000113581.8
    Conserved Domains (1) summary
    cl21494
    Location:22322
    Abhydrolase; alpha/beta hydrolases
  2. XM_036166100.1XP_036021993.1  monoglyceride lipase isoform X1

    Conserved Domains (1) summary
    cl21494
    Location:38338
    Abhydrolase; alpha/beta hydrolases
  3. XM_036166104.1XP_036021997.1  monoglyceride lipase isoform X5

    Conserved Domains (1) summary
    cl21494
    Location:10262
    Abhydrolase; alpha/beta hydrolases
  4. XM_036166103.1XP_036021996.1  monoglyceride lipase isoform X4

    Conserved Domains (1) summary
    cl21494
    Location:10290
    Abhydrolase; alpha/beta hydrolases
  5. XM_036166105.1XP_036021998.1  monoglyceride lipase isoform X6

    Conserved Domains (1) summary
    cl21494
    Location:2231
    Abhydrolase; alpha/beta hydrolases
  6. XM_036166102.1XP_036021995.1  monoglyceride lipase isoform X3

    Conserved Domains (1) summary
    cl21494
    Location:13293
    Abhydrolase; alpha/beta hydrolases
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