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Tenm4 teneurin transmembrane protein 4 [ Mus musculus (house mouse) ]

Gene ID: 23966, updated on 11-Apr-2024

Summary

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Official Symbol
Tenm4provided by MGI
Official Full Name
teneurin transmembrane protein 4provided by MGI
Primary source
MGI:MGI:2447063
See related
Ensembl:ENSMUSG00000048078 AllianceGenome:MGI:2447063
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Doc4; ELM2; Odz4; l7Rn3; Ten-m4; l(7)-3Rn; mKIAA1302
Summary
Enables protein homodimerization activity. Involved in central nervous system myelin formation; positive regulation of gastrulation; and regulation of nervous system development. Acts upstream of or within cardiac cell fate specification; cardiac muscle cell proliferation; and gastrulation with mouth forming second. Located in cytoplasm; neuron projection; and nucleus. Is integral component of plasma membrane. Is expressed in several structures, including branchial arch; central nervous system; forelimb bud; future brain; and somite. Human ortholog(s) of this gene implicated in essential tremor 5. Orthologous to human TENM4 (teneurin transmembrane protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in ovary adult (RPKM 25.2), subcutaneous fat pad adult (RPKM 11.8) and 10 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 E1; 7 52.53 cM
Exon count:
42
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (95550262..96560300)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (96171244..96911093)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57510 Neighboring gene STARR-seq mESC enhancer starr_19553 Neighboring gene predicted gene, 39049 Neighboring gene STARR-seq mESC enhancer starr_19555 Neighboring gene frataxin pseudogene Neighboring gene STARR-seq mESC enhancer starr_19557 Neighboring gene STARR-seq mESC enhancer starr_19558 Neighboring gene STARR-seq mESC enhancer starr_19562 Neighboring gene STARR-seq mESC enhancer starr_19563 Neighboring gene STARR-seq mESC enhancer starr_19564 Neighboring gene STARR-seq mESC enhancer starr_19567 Neighboring gene predicted gene 8319 Neighboring gene STARR-seq mESC enhancer starr_19570 Neighboring gene microRNA 708 Neighboring gene microRNA 6394 Neighboring gene predicted gene 15412 Neighboring gene STARR-seq mESC enhancer starr_19572 Neighboring gene ribosomal protein S11, pseudogene 5 Neighboring gene VISTA enhancer mm2003 Neighboring gene STARR-seq mESC enhancer starr_19576 Neighboring gene STARR-seq mESC enhancer starr_19579 Neighboring gene STARR-seq mESC enhancer starr_19580 Neighboring gene predicted gene 15413 Neighboring gene STARR-seq mESC enhancer starr_19583 Neighboring gene STARR-positive B cell enhancer mm9_chr7:104099810-104100111 Neighboring gene STARR-positive B cell enhancer mm9_chr7:104119017-104119317 Neighboring gene STARR-seq mESC enhancer starr_19585 Neighboring gene predicted gene, 22226 Neighboring gene asparaginyl-tRNA synthetase 2 (mitochondrial)(putative)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ten-m4 plays a unique role in the establishment of binocular visual circuits. Young TR, et al. Dev Neurobiol, 2023 Apr-May. PMID 37092850
  2. Development of type I/II oligodendrocytes regulated by teneurin-4 in the murine spinal cord. Hayashi C, et al. Sci Rep, 2020 May 25. PMID 32451386, Free PMC Article
  3. The extracellular domain of teneurin-4 promotes cell adhesion for oligodendrocyte differentiation. Hayashi C, et al. Biochem Biophys Res Commun, 2020 Feb 26. PMID 31839217
  4. Muscle Satellite Cell Protein Teneurin-4 Regulates Differentiation During Muscle Regeneration. Ishii K, et al. Stem Cells, 2015 Oct. PMID 26013034, Free PMC Article
  5. Teneurin-4 promotes cellular protrusion formation and neurite outgrowth through focal adhesion kinase signaling. Suzuki N, et al. FASEB J, 2014 Mar. PMID 24344332, Free PMC Article

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ten-m4 plays a unique role in the establishment of binocular visual circuits.
    Title: Ten-m4 plays a unique role in the establishment of binocular visual circuits.
  2. The extracellular domain of teneurin-4 promotes cell adhesion for oligodendrocyte differentiation.
    Title: The extracellular domain of teneurin-4 promotes cell adhesion for oligodendrocyte differentiation.
  3. our findings revealed that Ten-4 functions as a crucial player in maintaining the quiescence of muscle satellite cells
    Title: Muscle Satellite Cell Protein Teneurin-4 Regulates Differentiation During Muscle Regeneration.
  4. Ten-4 suppresses chondrogenic differentiation and regulates the expression and activation of the key molecules for chondrogenesis
    Title: Teneurin-4, a transmembrane protein, is a novel regulator that suppresses chondrogenic differentiation.
  5. data demonstrate that Tenm4 mutants fail to form a primitive streak and to induce embryonic mesoderm
    Title: Mouse Tenm4 is required for mesoderm induction.
  6. The results of this study suggested that Ten-4 is a novel regulator of oligodendrocyte differentiation and that it plays a critical role in the myelination of small-diameter axons in the CNS.
    Title: Teneurin-4 is a novel regulator of oligodendrocyte differentiation and myelination of small-diameter axons in the CNS.
Submit: New GeneRIF Correction

Phenotypes

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Associated conditions

Description Tests
lethal, Chr 7, Rinchik 3
GeneReviews: Not available

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cell adhesion molecule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein homodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cardiac cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cardiac muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in central nervous system myelin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in central nervous system myelin formation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within gastrulation with mouth forming second IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gastrulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of myelination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of oligodendrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of myelination ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in synaptic membrane adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic membrane adhesion NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuron projection IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
teneurin-4
Names
downstream of CHOP4
odd Oz/ten-m homolog 4
protein Odd Oz/ten-m homolog 4
ten-4
tenascin-M4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310760.1 → NP_001297689.1  teneurin-4 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC073599, AC162370, AK147579, BE980985
    Consensus CDS
    CCDS80753.1
    UniProtKB/Swiss-Prot
    Q3UHK6
    Related
    ENSMUSP00000102783.2, ENSMUST00000107165.8
    Conserved Domains (8) summary
    COG3209
    Location:1666 → 2362
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1296 → 1335
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2446 → 2525
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1286 → 1627
    NHL; NHL repeat unit of beta-propeller proteins
    pfam01414
    Location:808 → 850
    DSL; Delta serrate ligand
    pfam01500
    Location:691 → 839
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam06484
    Location:36 → 402
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2749 → 2826
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

  2. NM_001310762.1 → NP_001297691.1  teneurin-4 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, uses a downstream start codon, and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.
    Source sequence(s)
    AC073599, AC116683, AC158136, AC162370, AK147579, BE980985
    Consensus CDS
    CCDS80754.1
    UniProtKB/Swiss-Prot
    Q3UHK6
    Related
    ENSMUSP00000102780.2, ENSMUST00000107162.8
    Conserved Domains (10) summary
    COG3209
    Location:1738 → 2494
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1333 → 1382
    NHL; NHL repeat [structural motif]
    TIGR01643
    Location:1732 → 1772
    YD_repeat_2x; YD repeat (two copies)
    TIGR03696
    Location:2438 → 2517
    Rhs_assc_core; RHS repeat-associated core domain
    pfam01500
    Location:699 → 847
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam06484
    Location:11 → 410
    Ten_N; Teneurin Intracellular Region
    pfam07974
    Location:703 → 729
    EGF_2; EGF-like domain
    pfam15636
    Location:2743 → 2818
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:1285 → 1619
    NHL; NHL repeat unit of beta-propeller proteins
    cl19567
    Location:817 → 858
    DSL; Delta serrate ligand

  3. NM_011858.4 → NP_035988.2  teneurin-4 isoform 2

    See identical proteins and their annotated locations for NP_035988.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC162370, AK147329, BE980985
    Consensus CDS
    CCDS40024.1
    UniProtKB/Swiss-Prot
    Q3UHK6
    Related
    ENSMUSP00000102784.2, ENSMUST00000107166.8
    Conserved Domains (8) summary
    COG3209
    Location:1629 → 2325
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1259 → 1298
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2409 → 2488
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1249 → 1590
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:36 → 365
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2712 → 2789
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:593 → 728
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:772 → 813
    DSL; Delta serrate ligand

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    95550262..96560300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153061.1 → XP_036008954.1  teneurin-4 isoform X10

    Conserved Domains (8) summary
    COG3209
    Location:1699 → 2395
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1329 → 1368
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2479 → 2558
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1319 → 1660
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:36 → 435
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2782 → 2859
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:663 → 798
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:842 → 883
    DSL; Delta serrate ligand

  2. XM_006507806.4 → XP_006507869.1  teneurin-4 isoform X10

    See identical proteins and their annotated locations for XP_006507869.1

    Conserved Domains (8) summary
    COG3209
    Location:1699 → 2395
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1329 → 1368
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2479 → 2558
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1319 → 1660
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:36 → 435
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2782 → 2859
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:663 → 798
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:842 → 883
    DSL; Delta serrate ligand

  3. XM_030242548.1 → XP_030098408.1  teneurin-4 isoform X14

    Conserved Domains (8) summary
    COG3209
    Location:1629 → 2325
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1259 → 1298
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2409 → 2488
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1249 → 1590
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:36 → 365
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2712 → 2789
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:593 → 728
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:772 → 813
    DSL; Delta serrate ligand

  4. XM_036153067.1 → XP_036008960.1  teneurin-4 isoform X16

    Conserved Domains (8) summary
    COG3209
    Location:1596 → 2292
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1226 → 1265
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2376 → 2455
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1216 → 1557
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:36 → 332
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2679 → 2756
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:560 → 695
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:739 → 780
    DSL; Delta serrate ligand

  5. XM_036153070.1 → XP_036008963.1  teneurin-4 isoform X17

    Conserved Domains (7) summary
    COG3209
    Location:1587 → 2283
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1217 → 1256
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2367 → 2446
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1207 → 1548
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:36 → 332
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2670 → 2747
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:560 → 821
    exchanger_TraA; outer membrane exchange protein TraA

  6. XM_006507804.2 → XP_006507867.1  teneurin-4 isoform X10

    See identical proteins and their annotated locations for XP_006507867.1

    Conserved Domains (8) summary
    COG3209
    Location:1699 → 2395
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1329 → 1368
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2479 → 2558
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1319 → 1660
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:36 → 435
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2782 → 2859
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:663 → 798
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:842 → 883
    DSL; Delta serrate ligand

  7. XM_030242546.1 → XP_030098406.1  teneurin-4 isoform X13

    Conserved Domains (8) summary
    COG3209
    Location:1666 → 2362
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1296 → 1335
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2446 → 2525
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1286 → 1627
    NHL; NHL repeat unit of beta-propeller proteins
    pfam01414
    Location:808 → 850
    DSL; Delta serrate ligand
    pfam01500
    Location:691 → 839
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam06484
    Location:36 → 402
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2749 → 2826
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

  8. XM_030242544.1 → XP_030098404.1  teneurin-4 isoform X11

    Conserved Domains (8) summary
    COG3209
    Location:1674 → 2370
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1304 → 1343
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2454 → 2533
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1294 → 1635
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:11 → 410
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2757 → 2834
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:638 → 773
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:817 → 858
    DSL; Delta serrate ligand

  9. XM_030242550.1 → XP_030098410.1  teneurin-4 isoform X15

    UniProtKB/Swiss-Prot
    O70465, Q3TSI0, Q3UH52, Q3UHK6, Q80TF5, Q9WTS7
    Conserved Domains (8) summary
    COG3209
    Location:1604 → 2300
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1234 → 1273
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2384 → 2463
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1224 → 1565
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:11 → 340
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2687 → 2764
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:568 → 703
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:747 → 788
    DSL; Delta serrate ligand

  10. XM_030242545.1 → XP_030098405.1  teneurin-4 isoform X11

    Conserved Domains (8) summary
    COG3209
    Location:1674 → 2370
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1304 → 1343
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2454 → 2533
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1294 → 1635
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:11 → 410
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2757 → 2834
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:638 → 773
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:817 → 858
    DSL; Delta serrate ligand

  11. XM_030242551.1 → XP_030098411.1  teneurin-4 isoform X15

    UniProtKB/Swiss-Prot
    O70465, Q3TSI0, Q3UH52, Q3UHK6, Q80TF5, Q9WTS7
    Conserved Domains (8) summary
    COG3209
    Location:1604 → 2300
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1234 → 1273
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2384 → 2463
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1224 → 1565
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:11 → 340
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2687 → 2764
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:568 → 703
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:747 → 788
    DSL; Delta serrate ligand

  12. XM_036153062.1 → XP_036008955.1  teneurin-4 isoform X11

    Conserved Domains (8) summary
    COG3209
    Location:1674 → 2370
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1304 → 1343
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2454 → 2533
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1294 → 1635
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:11 → 410
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2757 → 2834
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:638 → 773
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:817 → 858
    DSL; Delta serrate ligand

  13. XM_036153066.1 → XP_036008959.1  teneurin-4 isoform X15

    UniProtKB/Swiss-Prot
    O70465, Q3TSI0, Q3UH52, Q3UHK6, Q80TF5, Q9WTS7
    Conserved Domains (8) summary
    COG3209
    Location:1604 → 2300
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1234 → 1273
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2384 → 2463
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1224 → 1565
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:11 → 340
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2687 → 2764
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:568 → 703
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:747 → 788
    DSL; Delta serrate ligand

  14. XM_036153052.1 → XP_036008945.1  teneurin-4 isoform X1

    Conserved Domains (8) summary
    COG3209
    Location:1817 → 2513
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1447 → 1486
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2597 → 2676
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1437 → 1778
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:154 → 553
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2900 → 2977
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:781 → 916
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:960 → 1001
    DSL; Delta serrate ligand

  15. XM_036153053.1 → XP_036008946.1  teneurin-4 isoform X2

    Conserved Domains (8) summary
    COG3209
    Location:1810 → 2506
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1447 → 1475
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2590 → 2669
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1437 → 1771
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:154 → 553
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2893 → 2970
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:781 → 916
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:960 → 1001
    DSL; Delta serrate ligand

  16. XM_036153054.1 → XP_036008947.1  teneurin-4 isoform X3

    Conserved Domains (7) summary
    COG3209
    Location:1808 → 2504
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1438 → 1477
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2588 → 2667
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1428 → 1769
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:154 → 553
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2891 → 2968
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:781 → 1042
    exchanger_TraA; outer membrane exchange protein TraA

  17. XM_036153055.1 → XP_036008948.1  teneurin-4 isoform X4

    Conserved Domains (7) summary
    COG3209
    Location:1801 → 2497
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1438 → 1466
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2581 → 2660
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1428 → 1762
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:154 → 553
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2884 → 2961
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:781 → 1042
    exchanger_TraA; outer membrane exchange protein TraA

  18. XM_036153056.1 → XP_036008949.1  teneurin-4 isoform X5

    Conserved Domains (8) summary
    COG3209
    Location:1784 → 2480
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1414 → 1453
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2564 → 2643
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1404 → 1745
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:154 → 520
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2867 → 2944
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:748 → 883
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:927 → 968
    DSL; Delta serrate ligand

  19. XM_036153072.1 → XP_036008965.1  teneurin-4 isoform X21

    Conserved Domains (8) summary
    COG3209
    Location:1777 → 2473
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1414 → 1442
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2557 → 2636
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1404 → 1738
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:154 → 520
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2860 → 2937
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:748 → 883
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:927 → 968
    DSL; Delta serrate ligand

  20. XM_036153057.1 → XP_036008950.1  teneurin-4 isoform X6

    Conserved Domains (7) summary
    COG3209
    Location:1775 → 2471
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1405 → 1444
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2555 → 2634
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1395 → 1736
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:154 → 520
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2858 → 2935
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:748 → 1009
    exchanger_TraA; outer membrane exchange protein TraA

  21. XM_036153058.1 → XP_036008951.1  teneurin-4 isoform X7

    Conserved Domains (8) summary
    COG3209
    Location:1747 → 2443
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1377 → 1416
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2527 → 2606
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1367 → 1708
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:154 → 483
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2830 → 2907
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:711 → 846
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:890 → 931
    DSL; Delta serrate ligand

  22. XM_036153059.1 → XP_036008952.1  teneurin-4 isoform X9

    Conserved Domains (8) summary
    COG3209
    Location:1714 → 2410
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1344 → 1383
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2494 → 2573
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1334 → 1675
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:154 → 450
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2797 → 2874
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:678 → 813
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:857 → 898
    DSL; Delta serrate ligand

  23. XM_030242552.1 → XP_030098412.1  teneurin-4 isoform X18

    Conserved Domains (8) summary
    COG3209
    Location:1571 → 2267
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1201 → 1240
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2351 → 2430
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1191 → 1532
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:11 → 307
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2654 → 2731
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:535 → 670
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:714 → 755
    DSL; Delta serrate ligand

  24. XM_006507805.3 → XP_006507868.1  teneurin-4 isoform X10

    See identical proteins and their annotated locations for XP_006507868.1

    Conserved Domains (8) summary
    COG3209
    Location:1699 → 2395
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1329 → 1368
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2479 → 2558
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1319 → 1660
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:36 → 435
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2782 → 2859
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:663 → 798
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:842 → 883
    DSL; Delta serrate ligand

  25. XM_030242549.2 → XP_030098409.1  teneurin-4 isoform X14

    Conserved Domains (8) summary
    COG3209
    Location:1629 → 2325
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1259 → 1298
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2409 → 2488
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1249 → 1590
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:36 → 365
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2712 → 2789
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:593 → 728
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:772 → 813
    DSL; Delta serrate ligand

  26. XM_036153060.1 → XP_036008953.1  teneurin-4 isoform X10

    Conserved Domains (8) summary
    COG3209
    Location:1699 → 2395
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1329 → 1368
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2479 → 2558
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1319 → 1660
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:36 → 435
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2782 → 2859
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:663 → 798
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:842 → 883
    DSL; Delta serrate ligand

  27. XM_036153069.1 → XP_036008962.1  teneurin-4 isoform X16

    Conserved Domains (8) summary
    COG3209
    Location:1596 → 2292
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1226 → 1265
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2376 → 2455
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1216 → 1557
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:36 → 332
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2679 → 2756
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:560 → 695
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:739 → 780
    DSL; Delta serrate ligand

  28. XM_006507807.5 → XP_006507870.1  teneurin-4 isoform X11

    See identical proteins and their annotated locations for XP_006507870.1

    Conserved Domains (8) summary
    COG3209
    Location:1674 → 2370
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1304 → 1343
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2454 → 2533
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1294 → 1635
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:11 → 410
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2757 → 2834
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:638 → 773
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:817 → 858
    DSL; Delta serrate ligand

  29. XM_036153065.1 → XP_036008958.1  teneurin-4 isoform X15

    UniProtKB/Swiss-Prot
    O70465, Q3TSI0, Q3UH52, Q3UHK6, Q80TF5, Q9WTS7
    Conserved Domains (8) summary
    COG3209
    Location:1604 → 2300
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1234 → 1273
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2384 → 2463
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1224 → 1565
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:11 → 340
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2687 → 2764
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:568 → 703
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:747 → 788
    DSL; Delta serrate ligand

  30. XM_036153071.1 → XP_036008964.1  teneurin-4 isoform X18

    Conserved Domains (8) summary
    COG3209
    Location:1571 → 2267
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1201 → 1240
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2351 → 2430
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1191 → 1532
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:11 → 307
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2654 → 2731
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:535 → 670
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:714 → 755
    DSL; Delta serrate ligand

  31. XM_006507803.5 → XP_006507866.1  teneurin-4 isoform X10

    See identical proteins and their annotated locations for XP_006507866.1

    Conserved Domains (8) summary
    COG3209
    Location:1699 → 2395
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1329 → 1368
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2479 → 2558
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1319 → 1660
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:36 → 435
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2782 → 2859
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:663 → 798
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:842 → 883
    DSL; Delta serrate ligand

  32. XM_036153064.1 → XP_036008957.1  teneurin-4 isoform X14

    Conserved Domains (8) summary
    COG3209
    Location:1629 → 2325
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1259 → 1298
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2409 → 2488
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1249 → 1590
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:36 → 365
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2712 → 2789
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:593 → 728
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:772 → 813
    DSL; Delta serrate ligand

  33. XM_036153068.1 → XP_036008961.1  teneurin-4 isoform X16

    Conserved Domains (8) summary
    COG3209
    Location:1596 → 2292
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1226 → 1265
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2376 → 2455
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1216 → 1557
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:36 → 332
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2679 → 2756
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:560 → 695
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:739 → 780
    DSL; Delta serrate ligand

  34. XM_006507808.5 → XP_006507871.1  teneurin-4 isoform X11

    See identical proteins and their annotated locations for XP_006507871.1

    Conserved Domains (8) summary
    COG3209
    Location:1674 → 2370
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1304 → 1343
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2454 → 2533
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1294 → 1635
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:11 → 410
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2757 → 2834
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:638 → 773
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:817 → 858
    DSL; Delta serrate ligand

  35. XM_006507801.5 → XP_006507864.1  teneurin-4 isoform X8

    Conserved Domains (8) summary
    COG3209
    Location:1740 → 2436
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1370 → 1409
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2520 → 2599
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1360 → 1701
    NHL; NHL repeat unit of beta-propeller proteins
    pfam01414
    Location:882 → 924
    DSL; Delta serrate ligand
    pfam01500
    Location:765 → 913
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam06484
    Location:77 → 476
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2823 → 2900
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

  36. XM_036153063.1 → XP_036008956.1  teneurin-4 isoform X12

    Conserved Domains (8) summary
    COG3209
    Location:1670 → 2366
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1300 → 1339
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2450 → 2529
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1290 → 1631
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:77 → 406
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2753 → 2830
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:634 → 769
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:813 → 854
    DSL; Delta serrate ligand

  37. XM_011241793.1 → XP_011240095.1  teneurin-4 isoform X11

    See identical proteins and their annotated locations for XP_011240095.1

    Conserved Domains (8) summary
    COG3209
    Location:1674 → 2370
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1304 → 1343
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2454 → 2533
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1294 → 1635
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:11 → 410
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2757 → 2834
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:638 → 773
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:817 → 858
    DSL; Delta serrate ligand

  38. XM_006507812.5 → XP_006507875.1  teneurin-4 isoform X19

    Conserved Domains (7) summary
    COG3209
    Location:852 → 1548
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd00054
    Location:51 → 80
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd05819
    Location:482 → 521
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:1632 → 1711
    Rhs_assc_core; RHS repeat-associated core domain
    pfam07974
    Location:10 → 36
    EGF_2; EGF-like domain
    cl18310
    Location:472 → 813
    NHL; NHL repeat unit of beta-propeller proteins
    pfam15636
    Location:1935 → 2012
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

  39. XM_006507813.5 → XP_006507876.1  teneurin-4 isoform X20

    Conserved Domains (7) summary
    COG3209
    Location:843 → 1539
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd00054
    Location:42 → 71
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd05819
    Location:473 → 512
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:1623 → 1702
    Rhs_assc_core; RHS repeat-associated core domain
    pfam07974
    Location:10 → 36
    EGF_2; EGF-like domain
    cl18310
    Location:463 → 804
    NHL; NHL repeat unit of beta-propeller proteins
    pfam15636
    Location:1926 → 2003
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UHK6.2 GenPept UniProtKB/Swiss-Prot:Q3UHK6

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