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Prkra protein kinase, interferon inducible double stranded RNA dependent activator [ Mus musculus (house mouse) ]

Gene ID: 23992, updated on 23-Jun-2021

Summary

Official Symbol
Prkraprovided by MGI
Official Full Name
protein kinase, interferon inducible double stranded RNA dependent activatorprovided by MGI
Primary source
MGI:MGI:1344375
See related
Ensembl:ENSMUSG00000002731
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P; R; l; Pa; PRK; RAX; Pact; lear; AV120107
Expression
Ubiquitous expression in CNS E18 (RPKM 16.2), CNS E14 (RPKM 14.3) and 28 other tissues See more
Orthologs
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Genomic context

See Prkra in Genome Data Viewer
Location:
2; 2 C3
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (76436385..76478614, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (76609215..76648220, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (76467994..76486051, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 45 Neighboring gene oxysterol binding protein-like 6 Neighboring gene pejvakin Neighboring gene FK506 binding protein 7

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme activator activity IEA
Inferred from Electronic Annotation
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables pre-miRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of RISC-loading complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
interferon-inducible double-stranded RNA-dependent protein kinase activator A
Names
PKR-associated protein X
PKR-associating protein X
protein activator of the interferon-induced protein kinase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011871.3NP_036001.1  interferon-inducible double-stranded RNA-dependent protein kinase activator A

    See identical proteins and their annotated locations for NP_036001.1

    Status: VALIDATED

    Source sequence(s)
    AL928867
    Consensus CDS
    CCDS16159.1
    UniProtKB/Swiss-Prot
    Q9WTX2
    Related
    ENSMUSP00000002808.7, ENSMUST00000002808.7
    Conserved Domains (3) summary
    cd19889
    Location:32102
    DSRM_PRKRA_rpt1; first double-stranded RNA binding motif of protein activator of the interferon-induced protein kinase (PRKRA) and similar proteins
    cd19891
    Location:126192
    DSRM_PRKRA_rpt2; second double-stranded RNA binding motif of protein activator of the interferon-induced protein kinase (PRKRA) and similar proteins
    cd19892
    Location:239310
    DSRM_PRKRA_rpt3; third double-stranded RNA binding motif of protein activator of the interferon-induced protein kinase (PRKRA) and similar proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    76436385..76478614 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250934.2XP_030106794.1  interferon-inducible double-stranded RNA-dependent protein kinase activator A isoform X1

    Conserved Domains (3) summary
    cd19889
    Location:113183
    DSRM_PRKRA_rpt1; first double-stranded RNA binding motif of protein activator of the interferon-induced protein kinase (PRKRA) and similar proteins
    cd19891
    Location:207273
    DSRM_PRKRA_rpt2; second double-stranded RNA binding motif of protein activator of the interferon-induced protein kinase (PRKRA) and similar proteins
    cl00054
    Location:320350
    DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily
  2. XM_017318023.3XP_017173512.1  interferon-inducible double-stranded RNA-dependent protein kinase activator A isoform X3

    Conserved Domains (2) summary
    cd19891
    Location:1379
    DSRM_PRKRA_rpt2; second double-stranded RNA binding motif of protein activator of the interferon-induced protein kinase (PRKRA) and similar proteins
    cd19892
    Location:126197
    DSRM_PRKRA_rpt3; third double-stranded RNA binding motif of protein activator of the interferon-induced protein kinase (PRKRA) and similar proteins
  3. XM_030250935.2XP_030106795.1  interferon-inducible double-stranded RNA-dependent protein kinase activator A isoform X2

    Conserved Domains (3) summary
    cd19889
    Location:113183
    DSRM_PRKRA_rpt1; first double-stranded RNA binding motif of protein activator of the interferon-induced protein kinase (PRKRA) and similar proteins
    cd19891
    Location:207273
    DSRM_PRKRA_rpt2; second double-stranded RNA binding motif of protein activator of the interferon-induced protein kinase (PRKRA) and similar proteins
    cl00054
    Location:320342
    DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily
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