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Zfp945 zinc finger protein 945 [ Mus musculus (house mouse) ]

Gene ID: 240041, updated on 8-Feb-2024

Summary

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Official Symbol
Zfp945provided by MGI
Official Full Name
zinc finger protein 945provided by MGI
Primary source
MGI:MGI:2445132
See related
Ensembl:ENSMUSG00000059142 AllianceGenome:MGI:2445132
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A630033E08Rik; C730040L01Rik
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in central nervous system and retina. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E14 (RPKM 2.5), CNS E11.5 (RPKM 2.4) and 23 other tissues See more
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Genomic context

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Location:
17 A3.3; 17 11.4 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (23065671..23086285, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (22846697..22867309, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11629 Neighboring gene STARR-seq mESC enhancer starr_42043 Neighboring gene predicted gene 5493 Neighboring gene STARR-seq mESC enhancer starr_42044 Neighboring gene zinc finger protein 946 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7496 Neighboring gene STARR-seq mESC enhancer starr_42045 Neighboring gene predicted gene, 32892 Neighboring gene zinc finger protein 40 pseudogene Neighboring gene vomeronasal 2, receptor, pseudogene 128

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  2. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein LOC240041

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110254.1 → NP_001103724.1  uncharacterized protein LOC240041 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AK041739, AK164594, AK168592, BC078460
    Consensus CDS
    CCDS50005.1
    UniProtKB/TrEMBL
    F6WAU7
    Related
    ENSMUSP00000086074.7, ENSMUST00000088696.13
    Conserved Domains (5) summary
    smart00349
    Location:34 → 92
    KRAB; krueppel associated box
    COG5048
    Location:340 → 754
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:653 → 673
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:34 → 73
    KRAB; KRAB box
    pfam13465
    Location:469 → 494
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001404089.1 → NP_001391018.1  uncharacterized protein LOC240041 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC154486

  3. NM_177358.4 → NP_796332.2  uncharacterized protein LOC240041 isoform b

    See identical proteins and their annotated locations for NP_796332.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an additional exon in the 5' region which results in translation initiation at a downstream start codon, compared to variant 1. The resulting isoform (b) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AK041739, AK164594, AK168592, BC078460
    Consensus CDS
    CCDS50004.1
    UniProtKB/TrEMBL
    E9PYM8, Q66L36
    Related
    ENSMUSP00000124123.4, ENSMUST00000160457.10
    Conserved Domains (4) summary
    COG5048
    Location:376 → 765
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:632 → 652
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:12 → 52
    KRAB; KRAB box
    pfam13465
    Location:337 → 361
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    23065671..23086285 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317465.3 → XP_017172954.1  uncharacterized protein LOC240041 isoform X3

    Conserved Domains (2) summary
    COG5048
    Location:338 → 727
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:594 → 614
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_036160596.1 → XP_036016489.1  uncharacterized protein LOC240041 isoform X4

    Conserved Domains (2) summary
    COG5048
    Location:333 → 722
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:589 → 609
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_030249781.2 → XP_030105641.1  uncharacterized protein LOC240041 isoform X2

    UniProtKB/TrEMBL
    E9PYM8, Q66L36
    Conserved Domains (4) summary
    COG5048
    Location:376 → 765
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:632 → 652
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:12 → 52
    KRAB; KRAB box
    pfam13465
    Location:337 → 361
    zf-H2C2_2; Zinc-finger double domain

  4. XM_036160594.1 → XP_036016487.1  uncharacterized protein LOC240041 isoform X1

    Conserved Domains (4) summary
    COG5048
    Location:391 → 780
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:647 → 667
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:27 → 67
    KRAB; KRAB box
    pfam13465
    Location:352 → 376
    zf-H2C2_2; Zinc-finger double domain

  5. XM_030249778.2 → XP_030105638.1  uncharacterized protein LOC240041 isoform X1

    Conserved Domains (4) summary
    COG5048
    Location:391 → 780
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:647 → 667
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:27 → 67
    KRAB; KRAB box
    pfam13465
    Location:352 → 376
    zf-H2C2_2; Zinc-finger double domain

  6. XM_036160595.1 → XP_036016488.1  uncharacterized protein LOC240041 isoform X4

    Conserved Domains (2) summary
    COG5048
    Location:333 → 722
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:589 → 609
    ZF_C2H2; C2H2 Zn finger [structural motif]

  7. XM_030249782.2 → XP_030105642.1  uncharacterized protein LOC240041 isoform X5

    Conserved Domains (2) summary
    COG5048
    Location:206 → 595
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:462 → 482
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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