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Neurl1b neuralized E3 ubiquitin protein ligase 1B [ Mus musculus (house mouse) ]

Gene ID: 240055, updated on 5-Mar-2024

Summary

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Official Symbol
Neurl1bprovided by MGI
Official Full Name
neuralized E3 ubiquitin protein ligase 1Bprovided by MGI
Primary source
MGI:MGI:3643092
See related
Ensembl:ENSMUSG00000034413 AllianceGenome:MGI:3643092
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EG240055; C230078M08Rik
Summary
Enables ubiquitin protein ligase activity. Involved in ubiquitin-dependent endocytosis. Located in early endosome. Is expressed in several structures, including alimentary system; brain; ganglia; spinal cord; and urinary system. Orthologous to human NEURL1B (neuralized E3 ubiquitin protein ligase 1B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in colon adult (RPKM 22.7), adrenal adult (RPKM 21.9) and 21 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 A3.3; 17 13.18 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (26633833..26665295)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (26414859..26446321)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene hemoglobin alpha, pseudogene 4 Neighboring gene predicted gene, 50015 Neighboring gene STARR-seq mESC enhancer starr_42122 Neighboring gene predicted gene, 34455 Neighboring gene STARR-seq mESC enhancer starr_42124 Neighboring gene STARR-seq mESC enhancer starr_42125 Neighboring gene STARR-seq mESC enhancer starr_42126 Neighboring gene STARR-positive B cell enhancer ABC_E5582 Neighboring gene dual specificity phosphatase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Neuralized-2: expression in human and rodents and interaction with Delta-like ligands. Rullinkov G, et al. Biochem Biophys Res Commun, 2009 Nov 20. PMID 19723503
  2. Neuralized-2 regulates a Notch ligand in cooperation with Mind bomb-1. Song R, et al. J Biol Chem, 2006 Nov 24. PMID 17003037
  3. An obligatory role of mind bomb-1 in notch signaling of mammalian development. Koo BK, et al. PLoS One, 2007 Nov 28. PMID 18043734, Free PMC Article
  4. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
  5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC183766, MGC183777

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase NEURL1B
Names
RING-type E3 ubiquitin transferase NEURL1B
neuralized homolog 1b
neuralized-like protein 1B
NP_001075125.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081656.3 → NP_001075125.1  E3 ubiquitin-protein ligase NEURL1B

    See identical proteins and their annotated locations for NP_001075125.1

    Status: VALIDATED

    Source sequence(s)
    AC157598
    Consensus CDS
    CCDS37513.1
    UniProtKB/Swiss-Prot
    C9DQJ8, Q0MW30
    Related
    ENSMUSP00000051481.7, ENSMUST00000053020.8
    Conserved Domains (4) summary
    smart00588
    Location:40 → 159
    NEUZ; domain in neuralized proteins
    pfam07177
    Location:41 → 106
    Neuralized; Neuralized
    pfam13920
    Location:490 → 540
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    cl02614
    Location:40 → 189
    SPRY; SPRY domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    26633833..26665295
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0MW30.1 GenPept UniProtKB/Swiss-Prot:Q0MW30

Gene LinkOut

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