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Jcad junctional cadherin 5 associated [ Mus musculus (house mouse) ]

Gene ID: 240185, updated on 31-Mar-2024

Summary

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Official Symbol
Jcadprovided by MGI
Official Full Name
junctional cadherin 5 associatedprovided by MGI
Primary source
MGI:MGI:2685174
See related
Ensembl:ENSMUSG00000033960 AllianceGenome:MGI:2685174
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm328; mKIAA1462; 1110056P05Rik; 9430020K01Rik
Summary
Involved in positive regulation of sprouting angiogenesis. Located in cell-cell junction. Is expressed in meninges; tail mesenchyme; and vertebral axis musculature. Orthologous to human JCAD (junctional cadherin 5 associated). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 23.0), cortex adult (RPKM 11.1) and 20 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 A1; 18 3.01 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (4590775..4682869)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (4590792..4682869)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene protein arginine N-methyltransferase 8 pseudogene Neighboring gene STARR-seq mESC enhancer starr_43680 Neighboring gene predicted gene, 41658 Neighboring gene STARR-seq mESC enhancer starr_43681 Neighboring gene STARR-seq mESC enhancer starr_43682 Neighboring gene STARR-seq mESC enhancer starr_43683 Neighboring gene predicted gene 5047 Neighboring gene STARR-positive B cell enhancer ABC_E7570 Neighboring gene STARR-seq mESC enhancer starr_43684 Neighboring gene predicted gene 10556 Neighboring gene predicted gene, 34269

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A key role for the novel coronary artery disease gene JCAD in atherosclerosis via shear stress mechanotransduction. Douglas G, et al. Cardiovasc Res, 2020 Sep 1. PMID 31584065, Free PMC Article
  2. Targeted Disruption of JCAD (Junctional Protein Associated With Coronary Artery Disease)/KIAA1462, a Coronary Artery Disease-Associated Gene Product, Inhibits Angiogenic Processes In Vitro and In Vivo. Hara T, et al. Arterioscler Thromb Vasc Biol, 2017 Sep. PMID 28705794
  3. JCAD promotes arterial thrombosis through PI3K/Akt modulation: a translational study. Liberale L, et al. Eur Heart J, 2023 May 21. PMID 36469488, Free PMC Article
  4. A coronary artery disease-associated gene product, JCAD/KIAA1462, is a novel component of endothelial cell-cell junctions. Akashi M, et al. Biochem Biophys Res Commun, 2011 Sep 23. PMID 21884682
  5. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. JCAD deficiency delayed liver regenerative repair through the Hippo-YAP signalling pathway.
    Title: JCAD deficiency delayed liver regenerative repair through the Hippo-YAP signalling pathway.
  2. JCAD promotes arterial thrombosis through PI3K/Akt modulation: a translational study.
    Title: JCAD promotes arterial thrombosis through PI3K/Akt modulation: a translational study.
  3. A key role for the novel coronary artery disease gene JCAD in atherosclerosis via shear stress mechanotransduction.
    Title: A key role for the novel coronary artery disease gene JCAD in atherosclerosis via shear stress mechanotransduction.
  4. JCAD has a redundant functional role in physiological angiogenesis but serves a pivotal role in pathological angiogenic process after birth.
    Title: Targeted Disruption of JCAD (Junctional Protein Associated With Coronary Artery Disease)/KIAA1462, a Coronary Artery Disease-Associated Gene Product, Inhibits Angiogenic Processes In Vitro and In Vivo.
  5. These results indicate that JCAD is a component of VE-cadherin-based cell-cell junctions in endothelial cells. This study also suggests the implication of endothelial cell-cell adhesion in coronary artery disease.
    Title: A coronary artery disease-associated gene product, JCAD/KIAA1462, is a novel component of endothelial cell-cell junctions.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1462

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of vascular endothelial growth factor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
  
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in ruffle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ruffle membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
junctional cadherin 5-associated protein
Names
junctional protein associated with coronary artery disease

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081963.1 → NP_001075432.1  junctional cadherin 5-associated protein

    See identical proteins and their annotated locations for NP_001075432.1

    Status: VALIDATED

    Source sequence(s)
    AC147227, AK220394, BU757028
    Consensus CDS
    CCDS37719.1
    UniProtKB/Swiss-Prot
    Q5DTX6
    UniProtKB/TrEMBL
    B7ZN02
    Related
    ENSMUSP00000038613.6, ENSMUST00000037029.7
    Conserved Domains (1) summary
    pfam15351
    Location:1 → 1309
    JCAD; Junctional protein associated with coronary artery disease

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    4590775..4682869
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525904.4 → XP_006525967.1  junctional cadherin 5-associated protein isoform X1

    See identical proteins and their annotated locations for XP_006525967.1

    UniProtKB/Swiss-Prot
    Q5DTX6
    UniProtKB/TrEMBL
    B7ZN02
    Related
    ENSMUSP00000157313.2, ENSMUST00000234153.2
    Conserved Domains (1) summary
    pfam15351
    Location:1 → 1309
    JCAD; Junctional protein associated with coronary artery disease

  2. XM_006525903.4 → XP_006525966.1  junctional cadherin 5-associated protein isoform X1

    See identical proteins and their annotated locations for XP_006525966.1

    UniProtKB/Swiss-Prot
    Q5DTX6
    UniProtKB/TrEMBL
    B7ZN02
    Conserved Domains (1) summary
    pfam15351
    Location:1 → 1309
    JCAD; Junctional protein associated with coronary artery disease
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5DTX6.2 GenPept UniProtKB/Swiss-Prot:Q5DTX6

Gene LinkOut

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