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Ccdc85b coiled-coil domain containing 85B [ Mus musculus (house mouse) ]

Gene ID: 240514, updated on 5-Mar-2024

Summary

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Official Symbol
Ccdc85bprovided by MGI
Official Full Name
coiled-coil domain containing 85Bprovided by MGI
Primary source
MGI:MGI:2147607
See related
Ensembl:ENSMUSG00000095098 AllianceGenome:MGI:2147607
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable delta-catenin binding activity. Involved in negative regulation of fat cell differentiation and negative regulation of transcription, DNA-templated. Located in nucleus. Orthologous to human CCDC85B (coiled-coil domain containing 85B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 8.3), lung adult (RPKM 7.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 A; 19 4.33 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (5503191..5507591, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (5453163..5457563, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 25432 Neighboring gene predicted gene, 31070 Neighboring gene fos-like antigen 1 Neighboring gene fibroblast growth factor (acidic) intracellular binding protein Neighboring gene cathepsin W Neighboring gene epidermal growth factor-containing fibulin-like extracellular matrix protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Delta-interacting protein A, a new inhibitory partner of CCAAT/enhancer-binding protein beta, implicated in adipocyte differentiation. Bezy O, et al. J Biol Chem, 2005 Mar 25. PMID 15644333
  2. The HSA21 gene EURL/C21ORF91 controls neurogenesis within the cerebral cortex and is implicated in the pathogenesis of Down Syndrome. Li SS, et al. Sci Rep, 2016 Jul 11. PMID 27404227, Free PMC Article
  3. ANKRD26 and its interacting partners TRIO, GPS2, HMMR and DIPA regulate adipogenesis in 3T3-L1 cells. Liu XF, et al. PLoS One, 2012. PMID 22666460, Free PMC Article
  4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC67311

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables delta-catenin binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of fat cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
  
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
coiled-coil domain-containing protein 85B
Names
delta-interacting protein A homolog
hepatitis delta antigen-interacting protein A homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243307.1 → NP_001230236.1  coiled-coil domain-containing protein 85B isoform 2

    See identical proteins and their annotated locations for NP_001230236.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a segment of the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC094592, BQ445696, BY124251, CK337075
    Consensus CDS
    CCDS89309.1
    UniProtKB/TrEMBL
    A0A494B9B6
    Related
    ENSMUSP00000157571.2, ENSMUST00000236881.2

  2. NM_198616.4 → NP_941018.1  coiled-coil domain-containing protein 85B isoform 1

    See identical proteins and their annotated locations for NP_941018.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC058411, BC094592, BY124251, CK337075
    Consensus CDS
    CCDS50357.1
    UniProtKB/Swiss-Prot
    Q6PDY0
    Related
    ENSMUSP00000137537.2, ENSMUST00000179549.3
    Conserved Domains (1) summary
    pfam10226
    Location:5 → 178
    CCDC85; CCDC85 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    5503191..5507591 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PDY0.1 GenPept UniProtKB/Swiss-Prot:Q6PDY0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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