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Sh3bp5 SH3-domain binding protein 5 (BTK-associated) [ Mus musculus (house mouse) ]

Gene ID: 24056, updated on 3-Apr-2024

Summary

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Official Symbol
Sh3bp5provided by MGI
Official Full Name
SH3-domain binding protein 5 (BTK-associated)provided by MGI
Primary source
MGI:MGI:1344391
See related
Ensembl:ENSMUSG00000021892 AllianceGenome:MGI:1344391
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sab; SH3BP-5
Summary
Predicted to enable guanyl-nucleotide exchange factor activity and protein kinase inhibitor activity. Involved in negative regulation of protein kinase activity. Predicted to be located in cytoplasmic vesicle membrane; mitochondrion; and nuclear body. Predicted to be active in cytoplasm. Orthologous to human SH3BP5 (SH3 domain binding protein 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 46.1), CNS E14 (RPKM 37.5) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 19.11 cM; 14 B
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (31094571..31158056, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (31372614..31436100, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene dynein, axonemal, heavy chain 1 Neighboring gene predicted gene, 35823 Neighboring gene STARR-positive B cell enhancer ABC_E10823 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:32149566-32149675 Neighboring gene calpain 7 Neighboring gene STARR-seq mESC enhancer starr_36314 Neighboring gene STARR-positive B cell enhancer mm9_chr14:32229701-32230002 Neighboring gene predicted gene, 35907 Neighboring gene STARR-positive B cell enhancer ABC_E7303 Neighboring gene PRELI domain-containing protein 2 pseudogene Neighboring gene methyltransferase 6, methylcytidine Neighboring gene STARR-seq mESC enhancer starr_36316 Neighboring gene ELL associated factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hepatic Mitochondrial SAB Deletion or Knockdown Alleviates Diet-Induced Metabolic Syndrome, Steatohepatitis, and Hepatic Fibrosis. Win S, et al. Hepatology, 2021 Dec. PMID 34331779, Free PMC Article
  2. c-Jun N-terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src. Win S, et al. Hepatology, 2016 Jun. PMID 26845758, Free PMC Article
  3. Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity. Win S, et al. J Hepatol, 2015 Jun. PMID 25666017, Free PMC Article
  4. JNK interaction with Sab mediates ER stress induced inhibition of mitochondrial respiration and cell death. Win S, et al. Cell Death Dis, 2014 Jan 9. PMID 24407242, Free PMC Article
  5. Assignment of SH3BP5/Sh3bp5 encoding sab, an SH3 domain-binding protein which preferentially associates with Bruton's tyrosine kinase, to human chromosome 1q43 and mouse chromosome 14B by in situ hybridization. Baba Y, et al. Cytogenet Cell Genet, 1999. PMID 10702676

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hepatic Mitochondrial SAB Deletion or Knockdown Alleviates Diet-Induced Metabolic Syndrome, Steatohepatitis, and Hepatic Fibrosis.
    Title: Hepatic Mitochondrial SAB Deletion or Knockdown Alleviates Diet-Induced Metabolic Syndrome, Steatohepatitis, and Hepatic Fibrosis.
  2. SAB expression levels determine the severity of JNK1-dependent liver injury
    Title: Expression of mitochondrial membrane-linked SAB determines severity of sex-dependent acute liver injury.
  3. The binding to and phosphorylation of Sab by p-JNK on the outer mitochondrial membrane leads to SHP1-dependent and DOK4-dependent inactivation of p-Src on the inner membrane; inactivation of mitochondrial Src inhibits electron transport and increases reactive oxygen species release, which sustains JNK activation and promotes cell death and organ injury.
    Title: c-Jun N-terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src.
  4. The interplay of p-JNK with mitochondrial Sab leads to impaired respiration, ROS production, sustained JNK activation, and apoptosis.
    Title: Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity.
  5. ER stress triggers an interaction of JNK with mitochondrial Sab, which leads to impaired respiration and increased mitochondrial reactive oxygen species.
    Title: JNK interaction with Sab mediates ER stress induced inhibition of mitochondrial respiration and cell death.
  6. SH3BP5 binds to JNK and directly inhibits JNK through its two putative mitogen-activated protein kinase interaction motifs (KIMs).
    Title: SH3-binding protein 5 mediates the neuroprotective effect of the secreted bioactive peptide humanin by inhibiting c-Jun NH2-terminal kinase.
  7. JNK-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice
    Title: c-Jun N-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH3 domain binding TAS
Traceable Author Statement
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in negative regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IC
Inferred by Curator
more info
 PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
SH3 domain-binding protein 5
Names
SH3 domain-binding protein that preferentially associates with BTK

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347585.2 → NP_001334514.1  SH3 domain-binding protein 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC108416, AC154616
    Consensus CDS
    CCDS84108.1
    UniProtKB/Swiss-Prot
    Q3TTD6, Q8C903, Q8VCZ0, Q9Z131
    Related
    ENSMUSP00000098296.4, ENSMUST00000100730.10

  2. NM_001404586.1 → NP_001391515.1  SH3 domain-binding protein 5 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC108416, AC154616

  3. NM_001404587.1 → NP_001391516.1  SH3 domain-binding protein 5 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC108416, AC154616

  4. NM_001404588.1 → NP_001391517.1  SH3 domain-binding protein 5 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC108416, AC154616

  5. NM_001404589.1 → NP_001391518.1  SH3 domain-binding protein 5 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC108416, AC154616

  6. NM_011894.4 → NP_036024.2  SH3 domain-binding protein 5 isoform 1

    See identical proteins and their annotated locations for NP_036024.2

    Status: VALIDATED

    Source sequence(s)
    AC108416, AC154616
    Consensus CDS
    CCDS36855.1
    UniProtKB/Swiss-Prot
    Q3TTD6, Q8C903, Q8VCZ0, Q9Z131
    Related
    ENSMUSP00000089517.5, ENSMUST00000091903.5
    Conserved Domains (1) summary
    pfam05276
    Location:44 → 270
    SH3BP5; SH3 domain-binding protein 5 (SH3BP5)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    31094571..31158056 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247814.1 → XP_030103674.1  SH3 domain-binding protein 5 isoform X1

    Conserved Domains (1) summary
    pfam05276
    Location:1 → 112
    SH3BP5; SH3 domain-binding protein 5 (SH3BP5)

  2. XM_030247815.1 → XP_030103675.1  SH3 domain-binding protein 5 isoform X1

    Conserved Domains (1) summary
    pfam05276
    Location:1 → 112
    SH3BP5; SH3 domain-binding protein 5 (SH3BP5)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z131.3 GenPept UniProtKB/Swiss-Prot:Q9Z131

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