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Tpra1 transmembrane protein, adipocyte asscociated 1 [ Mus musculus (house mouse) ]

Gene ID: 24100, updated on 5-Mar-2024

Summary

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Official Symbol
Tpra1provided by MGI
Official Full Name
transmembrane protein, adipocyte asscociated 1provided by MGI
Primary source
MGI:MGI:1345190
See related
Ensembl:ENSMUSG00000002871 AllianceGenome:MGI:1345190
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
40kDa; Gpr175; Tpra40
Summary
Predicted to enable G protein-coupled receptor activity. Acts upstream of or within embryonic cleavage and negative regulation of mitotic cell cycle phase transition. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in brain. Orthologous to human TPRA1 (transmembrane protein adipocyte associated 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 50.6), ovary adult (RPKM 24.2) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Tpra1 in Genome Data Viewer
Location:
6 D1; 6 39.65 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (88879238..88889216)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (88902251..88912240)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene 15612 Neighboring gene podocalyxin-like 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:88836578-88836779 Neighboring gene minichromosome maintenance complex component 2 Neighboring gene STARR-positive B cell enhancer ABC_E2794 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:88852049-88852232 Neighboring gene predicted gene, 36268 Neighboring gene STARR-positive B cell enhancer ABC_E2795 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:88889573-88889760 Neighboring gene predicted gene, 53294

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Differential expression of a novel seven transmembrane domain protein in epididymal fat from aged and diabetic mice. Yang H, et al. Endocrinology, 1999 Jun. PMID 10342878
  2. TPRA40/GPR175 regulates early mouse embryogenesis through functional membrane transport by Sjögren's syndrome-associated protein NA14. Aki T, et al. J Cell Physiol, 2008 Oct. PMID 18459117
  3. Identifying new candidate genes for hereditary facial paresis on chromosome 3q21-q22 by RNA in situ hybridization in mouse. van der Zwaag B, et al. Genomics, 2005 Jul. PMID 15953540
  4. Mapping of QTLs for oral alcohol self-administration in B6.C and B6.I quasi-congenic RQI strains. Vadasz C, et al. Neurochem Res, 2007 Jul. PMID 17273929, Free PMC Article
  5. The G protein-coupled receptor repertoires of human and mouse. Vassilatis DK, et al. Proc Natl Acad Sci U S A, 2003 Apr 15. PMID 12679517, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the functional plasma membrane transport of TPRA40 that regulates cell division of mouse embryos is mediated by NA14.
    Title: TPRA40/GPR175 regulates early mouse embryogenesis through functional membrane transport by Sjögren's syndrome-associated protein NA14.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within embryonic cleavage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of mitotic cell cycle phase transition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
transmembrane protein adipocyte-associated 1
Names
G protein-coupled receptor 175
integral membrane protein GPR175
transmembrane domain protein of 40 kDa regulated in adipocytes
transmembrane domain protein regulated in adipocytes 40 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410580.1 → NP_001397509.1  transmembrane protein adipocyte-associated 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC153923

  2. NM_001410581.1 → NP_001397510.1  transmembrane protein adipocyte-associated 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC153923

  3. NM_011906.3 → NP_036036.2  transmembrane protein adipocyte-associated 1 isoform 1

    See identical proteins and their annotated locations for NP_036036.2

    Status: VALIDATED

    Source sequence(s)
    AC153923
    Consensus CDS
    CCDS39555.1
    UniProtKB/Swiss-Prot
    Q80UD9, Q8C240, Q91Z36, Q99MU1, Q9Z112
    Related
    ENSMUSP00000145050.2, ENSMUST00000204765.3
    Conserved Domains (1) summary
    pfam10160
    Location:36 → 309
    Tmemb_40; Predicted membrane protein

RNA

  1. NR_177087.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153923

  2. NR_177088.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153923

  3. NR_177089.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153923

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    88879238..88889216
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036166106.1 → XP_036021999.1  transmembrane protein adipocyte-associated 1 isoform X1

    UniProtKB/Swiss-Prot
    Q80UD9, Q8C240, Q91Z36, Q99MU1, Q9Z112
    Conserved Domains (1) summary
    pfam10160
    Location:36 → 309
    Tmemb_40; Predicted membrane protein

  2. XM_006506063.3 → XP_006506126.1  transmembrane protein adipocyte-associated 1 isoform X1

    See identical proteins and their annotated locations for XP_006506126.1

    UniProtKB/Swiss-Prot
    Q80UD9, Q8C240, Q91Z36, Q99MU1, Q9Z112
    Related
    ENSMUSP00000145168.2, ENSMUST00000203185.3
    Conserved Domains (1) summary
    pfam10160
    Location:36 → 309
    Tmemb_40; Predicted membrane protein

  3. XM_036166107.1 → XP_036022000.1  transmembrane protein adipocyte-associated 1 isoform X1

    UniProtKB/Swiss-Prot
    Q80UD9, Q8C240, Q91Z36, Q99MU1, Q9Z112
    Conserved Domains (1) summary
    pfam10160
    Location:36 → 309
    Tmemb_40; Predicted membrane protein

  4. XM_006506062.3 → XP_006506125.1  transmembrane protein adipocyte-associated 1 isoform X1

    See identical proteins and their annotated locations for XP_006506125.1

    UniProtKB/Swiss-Prot
    Q80UD9, Q8C240, Q91Z36, Q99MU1, Q9Z112
    Conserved Domains (1) summary
    pfam10160
    Location:36 → 309
    Tmemb_40; Predicted membrane protein

  5. XM_006506061.4 → XP_006506124.1  transmembrane protein adipocyte-associated 1 isoform X1

    See identical proteins and their annotated locations for XP_006506124.1

    UniProtKB/Swiss-Prot
    Q80UD9, Q8C240, Q91Z36, Q99MU1, Q9Z112
    Conserved Domains (1) summary
    pfam10160
    Location:36 → 309
    Tmemb_40; Predicted membrane protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99MU1.1 GenPept UniProtKB/Swiss-Prot:Q99MU1

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