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Neu4 sialidase 4 [ Mus musculus (house mouse) ]

Gene ID: 241159, updated on 25-Jan-2022

Summary

Official Symbol
Neu4provided by MGI
Official Full Name
sialidase 4provided by MGI
Primary source
MGI:MGI:2661364
See related
Ensembl:ENSMUSG00000034000 AllianceGenome:MGI:2661364
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9330166I04
Summary
Enables exo-alpha-(2->3)-sialidase activity and exo-alpha-(2->8)-sialidase activity. Involved in ganglioside catabolic process; glycoprotein catabolic process; and negative regulation of neuron projection development. Located in neuron projection and plasma membrane. Is expressed in brain. Orthologous to human NEU4 (neuraminidase 4). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in cortex adult (RPKM 1.5), frontal lobe adult (RPKM 1.4) and 1 other tissue See more
Orthologs
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Genomic context

See Neu4 in Genome Data Viewer
Location:
1; 1 D
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (93948215..93956056)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (94020493..94028334)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (95917070..95924911)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene D-2-hydroxyglutarate dehydrogenase pseudogene Neighboring gene galactose-3-O-sulfotransferase 2C Neighboring gene programmed cell death 1 Neighboring gene predicted gene 7891

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables exo-alpha-(2->3)-sialidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables exo-alpha-(2->3)-sialidase activity ISO
Inferred from Sequence Orthology
more info
 
enables exo-alpha-(2->6)-sialidase activity IEA
Inferred from Electronic Annotation
more info
 
enables exo-alpha-(2->8)-sialidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables exo-alpha-(2->8)-sialidase activity ISO
Inferred from Sequence Orthology
more info
 
enables exo-alpha-sialidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables exo-alpha-sialidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables exo-alpha-sialidase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in organelle inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
sialidase-4
Names
N-acetyl-alpha-neuraminidase 4
neuraminidase 4
NP_001297698.1
NP_776133.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310769.1NP_001297698.1  sialidase-4 isoform 1

    See identical proteins and their annotated locations for NP_001297698.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB510404, BC070438, CB521925
    Consensus CDS
    CCDS78660.1
    UniProtKB/Swiss-Prot
    Q8BZL1
    UniProtKB/TrEMBL
    C5NTX9
    Related
    ENSMUSP00000140127.2, ENSMUST00000190212.7
    Conserved Domains (1) summary
    cd15482
    Location:33473
    Sialidase_non-viral; Non-viral sialidases
  2. NM_173772.3NP_776133.1  sialidase-4 isoform 2

    See identical proteins and their annotated locations for NP_776133.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1, which causes translation initiation at a downstream AUG. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    BC070438
    Consensus CDS
    CCDS15199.1
    UniProtKB/Swiss-Prot
    Q8BZL1
    Related
    ENSMUSP00000051151.7, ENSMUST00000050890.8
    Conserved Domains (1) summary
    cd15482
    Location:10450
    Sialidase_non-viral; Non-viral sialidases

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    93948215..93956056
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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