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Itga8 integrin alpha 8 [ Mus musculus (house mouse) ]

Gene ID: 241226, updated on 23-Jun-2021

Summary

Official Symbol
Itga8provided by MGI
Official Full Name
integrin alpha 8provided by MGI
Primary source
MGI:MGI:109442
See related
Ensembl:ENSMUSG00000026768
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI447669
Summary
This gene encodes a member of the integrin family of cell surface proteins that mediate cellular interactions with the extracellular matrix and other cells. The encoded protein undergoes proteolytic processing to generate the disulfide-linked heterodimeric alpha subunit which, in turn associates with a beta subunit to form the functional integrin receptor. Mice lacking the encoded protein mostly die after birth due to kidney defects, but some of animals that survive exhibit defects in the sensory hair cells of the inner ear. [provided by RefSeq, Aug 2016]
Expression
Biased expression in lung adult (RPKM 16.4), bladder adult (RPKM 4.7) and 14 other tissues See more
Orthologs
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Genomic context

See Itga8 in Genome Data Viewer
Location:
2 A1; 2 9.12 cM
Exon count:
33
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (12111443..12306796, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (12106632..12301985, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (12028287..12223547, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm30 Neighboring gene karyopherin (importin) alpha 2 pseudogene Neighboring gene RIKEN cDNA E030013I19 gene Neighboring gene MINDY lysine 48 deubiquitinase 3 Neighboring gene predicted gene 13321

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell projection organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within extracellular matrix organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within inner ear morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in kidney development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within metanephros development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within metanephros development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transforming growth factor beta receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in smooth muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
part_of integrin complex IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001309.3NP_001001309.1  integrin alpha-8 preproprotein

    See identical proteins and their annotated locations for NP_001001309.1

    Status: REVIEWED

    Source sequence(s)
    AK033007, AK044910, AK135193, AL845313, BC137793, BQ175493
    Consensus CDS
    CCDS15689.1
    UniProtKB/Swiss-Prot
    A2ARA8
    Related
    ENSMUSP00000028106.5, ENSMUST00000028106.11
    Conserved Domains (3) summary
    smart00191
    Location:382436
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam00357
    Location:10341048
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:482933
    Integrin_alpha2; Integrin alpha

RNA

  1. NR_138462.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AK033007, AK044910, AL845313, BC137793, BQ175493
    Related
    ENSMUST00000172791.8

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    12111443..12306796 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497475.4XP_006497538.1  integrin alpha-8 isoform X1

    Conserved Domains (3) summary
    smart00191
    Location:382436
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam00357
    Location:10511065
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:482933
    Integrin_alpha2; Integrin alpha
  2. XM_006497476.4XP_006497539.1  integrin alpha-8 isoform X2

    Conserved Domains (2) summary
    pfam00357
    Location:592606
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:23474
    Integrin_alpha2; Integrin alpha
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