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Zbtb6 zinc finger and BTB domain containing 6 [ Mus musculus (house mouse) ]

Gene ID: 241322, updated on 5-Mar-2024

Summary

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Official Symbol
Zbtb6provided by MGI
Official Full Name
zinc finger and BTB domain containing 6provided by MGI
Primary source
MGI:MGI:2442998
See related
Ensembl:ENSMUSG00000066798 AllianceGenome:MGI:2442998
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ZID; Zfp482; A830092L04Rik
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in mitochondrion. Predicted to be active in nucleoplasm. Is expressed in several structures, including bladder; nervous system; and retina. Orthologous to human ZBTB6 (zinc finger and BTB domain containing 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 5.5), whole brain E14.5 (RPKM 4.7) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 B; 2 24.19 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (37315512..37320931, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (37425500..37430919, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4441 Neighboring gene STARR-seq mESC enhancer starr_04312 Neighboring gene phosducin-like Neighboring gene STARR-positive B cell enhancer ABC_E7813 Neighboring gene ring finger and CCCH-type zinc finger domains 2 Neighboring gene STARR-seq mESC enhancer starr_04313 Neighboring gene small nucleolar RNA, C/D box 90 Neighboring gene STARR-positive B cell enhancer ABC_E1244 Neighboring gene STARR-positive B cell enhancer ABC_E11130 Neighboring gene STARR-positive B cell enhancer ABC_E4442 Neighboring gene STARR-positive B cell enhancer ABC_E1004 Neighboring gene zinc finger and BTB domain containing 26 Neighboring gene RAB GTPase activating protein 1 Neighboring gene nucleoporin 37 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex. Medeiros de Araújo JA, et al. Development, 2021 Aug 15. PMID 34351428, Free PMC Article
  2. Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun. Gurdziel K, et al. Dev Dyn, 2016 May. PMID 26930384, Free PMC Article
  3. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269
  4. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
  5. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: Zbtb26

Homology

Clone Names

  • MGC41441

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger and BTB domain-containing protein 6
Names
zinc finger protein 482

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_146253.5 → NP_666365.1  zinc finger and BTB domain-containing protein 6

    See identical proteins and their annotated locations for NP_666365.1

    Status: VALIDATED

    Source sequence(s)
    AK050827, AL953890, CF168206
    Consensus CDS
    CCDS16000.1
    UniProtKB/Swiss-Prot
    A2AWA4, Q8BLM4, Q8K088
    Related
    ENSMUSP00000056100.6, ENSMUST00000053098.6
    Conserved Domains (5) summary
    smart00225
    Location:34 → 127
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:327 → 347
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:325 → 347
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:23 → 123
    BTB; BTB/POZ domain
    pfam13465
    Location:339 → 363
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    37315512..37320931 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K088.1 GenPept UniProtKB/Swiss-Prot:Q8K088

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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