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Pak5 p21 (RAC1) activated kinase 5 [ Mus musculus (house mouse) ]

Gene ID: 241656, updated on 8-Jul-2021

Summary

Official Symbol
Pak5provided by MGI
Official Full Name
p21 (RAC1) activated kinase 5provided by MGI
Primary source
MGI:MGI:1920334
See related
Ensembl:ENSMUSG00000039913
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pa; Pak7; PAK-5; PAK-7; 2900083L08Rik
Expression
Biased expression in CNS E18 (RPKM 6.8), cortex adult (RPKM 6.4) and 5 other tissues See more
Orthologs
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Genomic context

See Pak5 in Genome Data Viewer
Location:
2; 2 F3
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (135923008..136229899, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (136081088..136387968, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (135906824..136213703, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 26227 Neighboring gene lysosomal-associated membrane protein family, member 5 Neighboring gene predicted gene 14218 Neighboring gene predicted gene, 39942 Neighboring gene ribosomal protein 10 pseudogene Neighboring gene predicted gene, 32546

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC117585, 6430627N20, 2900083L08Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in activation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within learning IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within locomotory behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within memory IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
is_active_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase PAK 5
Names
p21 (RAC1) activated kinase 7
p21 protein (Cdc42/Rac)-activated kinase 7
p21-activated kinase 5
p21-activated kinase 7
serine/threonine-protein kinase PAK 7
NP_001347311.1
NP_001347313.1
NP_766446.2
XP_006499571.1
XP_006499573.1
XP_017173707.1
XP_017173708.1
XP_030107020.1
XP_036017869.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360382.1NP_001347311.1  serine/threonine-protein kinase PAK 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 through 3 encode the same protein.
    Source sequence(s)
    AK079080, AL845354, BB621357
    Consensus CDS
    CCDS16790.1
    Related
    ENSMUSP00000047285.3, ENSMUST00000035264.9
    Conserved Domains (2) summary
    cd06658
    Location:426717
    STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5
    cd01093
    Location:955
    CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
  2. NM_001360384.1NP_001347313.1  serine/threonine-protein kinase PAK 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 through 3 encode the same protein.
    Source sequence(s)
    AL845354, AL928792, BX294446
    Consensus CDS
    CCDS16790.1
    Conserved Domains (2) summary
    cd06658
    Location:426717
    STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5
    cd01093
    Location:955
    CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
  3. NM_172858.2NP_766446.2  serine/threonine-protein kinase PAK 5

    See identical proteins and their annotated locations for NP_766446.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 through 3 encode the same protein.
    Source sequence(s)
    AK032593, AK163530, AL845354, AL928792
    Consensus CDS
    CCDS16790.1
    UniProtKB/Swiss-Prot
    Q8C015
    Related
    ENSMUSP00000076440.4, ENSMUST00000077200.4
    Conserved Domains (2) summary
    cd06658
    Location:426717
    STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5
    cd01093
    Location:955
    CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    135923008..136229899 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499508.5XP_006499571.1  serine/threonine-protein kinase PAK 5 isoform X1

    Conserved Domains (2) summary
    cd06658
    Location:443734
    STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5
    cd01093
    Location:2672
    CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
  2. XM_030251160.2XP_030107020.1  serine/threonine-protein kinase PAK 5 isoform X2

    Conserved Domains (2) summary
    cd06658
    Location:426717
    STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5
    cd01093
    Location:955
    CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
  3. XM_006499510.5XP_006499573.1  serine/threonine-protein kinase PAK 5 isoform X3

    Conserved Domains (2) summary
    cd06658
    Location:181472
    STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5
    cd01093
    Location:2672
    CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
  4. XM_017318219.3XP_017173708.1  serine/threonine-protein kinase PAK 5 isoform X4

    Conserved Domains (2) summary
    cd06658
    Location:164455
    STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5
    cd01093
    Location:955
    CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
  5. XM_036161976.1XP_036017869.1  serine/threonine-protein kinase PAK 5 isoform X2

    Conserved Domains (2) summary
    cd06658
    Location:426717
    STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5
    cd01093
    Location:955
    CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
  6. XM_017318218.1XP_017173707.1  serine/threonine-protein kinase PAK 5 isoform X2

    UniProtKB/Swiss-Prot
    Q8C015
    Conserved Domains (2) summary
    cd06658
    Location:426717
    STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5
    cd01093
    Location:955
    CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
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