Pak5 p21 (RAC1) activated kinase 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pak5provided by MGI
Official Full Name: p21 (RAC1) activated kinase 5provided by MGI
Primary source: MGI:MGI:1920334
See related: Ensembl:ENSMUSG00000039913 AllianceGenome:MGI:1920334
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pak7; PAK-5; PAK-7; 2900083L08Rik
Summary: Enables protein serine/threonine kinase activity. Acts upstream of or within learning or memory; locomotory behavior; and negative regulation of extrinsic apoptotic signaling pathway. Located in mitochondrion. Is active in synapse. Is expressed in brain. Orthologous to human PAK5 (p21 (RAC1) activated kinase 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E18 (RPKM 6.8), cortex adult (RPKM 6.4) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 F3; 2 67.32 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (135923008..136229899, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (136081088..136387968, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PAK-7 p21-activated kinase 5 knockout mice are more sensitive to the stimulant effects of amphetamine
Title: Differential sensitivity of Pak5, Pak6, and Pak5/Pak6 double-knockout mice to the stimulant effects of amphetamine and exercise-induced alterations in body weight.
functional deficits in PAK5, PAK6 and PAK5/PAK6 knockout mice
Title: Functional deficits in PAK5, PAK6 and PAK5/PAK6 knockout mice.
PAK 5 is involved in formalin-induced inflammatory nociception through regulation of MAPK-induced c-Fos-activation and formalin-specific transient receptor potential-channels.
Title: The p21-activated kinase PAK 5 is involved in formalin-induced nociception through regulation of MAP-kinase signaling and formalin-specific receptors.
These results implicate Pak5 in Pacsin1- and Synaptojanin1-mediated synaptic vesicle trafficking.
Title: Identification of neuronal substrates implicates Pak5 in synaptic vesicle trafficking.
Our results indicate that Pak5 and Pak6 together are not required for viability, but are required for a normal level of locomotion and activity as well as for learning and memory.
Title: Targeted disruption of the Pak5 and Pak6 genes in mice leads to deficits in learning and locomotion.
PAK5 may provide a molecular rationale for late-stage complications in diabetes.
Title: RSK4 and PAK5 are novel candidate genes in diabetic rat kidney and brain.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC230317P1 (e-PCR)
- UniSTS:272184

NoName (e-PCR)
- UniSTS:224962

D2Mit136 (e-PCR), detects polymorphism
- UniSTS:128996

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within learning	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within locomotory behavior	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within memory	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IEP Inferred from Expression Pattern more info	PubMed

General protein information

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Preferred Names: serine/threonine-protein kinase PAK 5

Names: p21 (RAC1) activated kinase 7; p21 protein (Cdc42/Rac)-activated kinase 7; p21-activated kinase 5; p21-activated kinase 7; serine/threonine-protein kinase PAK 7

NP_001347311.1

EC 2.7.11.1

NP_001347313.1

EC 2.7.11.1

NP_766446.2

EC 2.7.11.1

XP_006499571.1

EC 2.7.11.1

XP_006499573.1

EC 2.7.11.1

XP_017173707.1

EC 2.7.11.1

XP_017173708.1

EC 2.7.11.1

XP_030107020.1

EC 2.7.11.1

XP_036017869.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001360382.1 → NP_001347311.1 serine/threonine-protein kinase PAK 5

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1 through 3 encode the same protein.

Source sequence(s)

AK079080, AL845354, BB621357

Consensus CDS

CCDS16790.1

UniProtKB/Swiss-Prot

Q3TQJ7, Q6RWS7, Q8C015

UniProtKB/TrEMBL

Q8BVB0

Related

ENSMUSP00000047285.3, ENSMUST00000035264.9

Conserved Domains (2) summary

cd06658
Location:426 → 717

STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5

cd01093
Location:9 → 55

CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
NM_001360384.1 → NP_001347313.1 serine/threonine-protein kinase PAK 5

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 through 3 encode the same protein.

Source sequence(s)

AL845354, AL928792, BX294446

Consensus CDS

CCDS16790.1

UniProtKB/Swiss-Prot

Q3TQJ7, Q6RWS7, Q8C015

UniProtKB/TrEMBL

Q8BVB0

Conserved Domains (2) summary

cd06658
Location:426 → 717

STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5

cd01093
Location:9 → 55

CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
NM_172858.2 → NP_766446.2 serine/threonine-protein kinase PAK 5

See identical proteins and their annotated locations for NP_766446.2

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 through 3 encode the same protein.

Source sequence(s)

AK032593, AK163530, AL845354, AL928792

Consensus CDS

CCDS16790.1

UniProtKB/Swiss-Prot

Q3TQJ7, Q6RWS7, Q8C015

UniProtKB/TrEMBL

Q8BVB0

Related

ENSMUSP00000076440.4, ENSMUST00000077200.4

Conserved Domains (2) summary

cd06658
Location:426 → 717

STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5

cd01093
Location:9 → 55

CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

135923008..136229899 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006499508.5 → XP_006499571.1 serine/threonine-protein kinase PAK 5 isoform X1

UniProtKB/TrEMBL

Q8BVB0

Conserved Domains (2) summary

cd06658
Location:443 → 734

STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5

cd01093
Location:26 → 72

CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
XM_030251160.2 → XP_030107020.1 serine/threonine-protein kinase PAK 5 isoform X2

UniProtKB/Swiss-Prot

Q3TQJ7, Q6RWS7, Q8C015

UniProtKB/TrEMBL

Q8BVB0

Conserved Domains (2) summary

cd06658
Location:426 → 717

STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5

cd01093
Location:9 → 55

CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
XM_006499510.5 → XP_006499573.1 serine/threonine-protein kinase PAK 5 isoform X3

Conserved Domains (2) summary

cd06658
Location:181 → 472

STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5

cd01093
Location:26 → 72

CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
XM_017318219.3 → XP_017173708.1 serine/threonine-protein kinase PAK 5 isoform X4

Conserved Domains (2) summary

cd06658
Location:164 → 455

STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5

cd01093
Location:9 → 55

CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
XM_036161976.1 → XP_036017869.1 serine/threonine-protein kinase PAK 5 isoform X2

UniProtKB/Swiss-Prot

Q3TQJ7, Q6RWS7, Q8C015

UniProtKB/TrEMBL

Q8BVB0

Conserved Domains (2) summary

cd06658
Location:426 → 717

STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5

cd01093
Location:9 → 55

CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
XM_017318218.1 → XP_017173707.1 serine/threonine-protein kinase PAK 5 isoform X2

UniProtKB/Swiss-Prot

Q3TQJ7, Q6RWS7, Q8C015

UniProtKB/TrEMBL

Q8BVB0

Conserved Domains (2) summary

cd06658
Location:426 → 717

STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5

cd01093
Location:9 → 55

CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...