Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Atp1a1provided by RGD
Official Full Name: ATPase Na+/K+ transporting subunit alpha 1provided by RGD
Primary source: RGD:2167
See related: Ensembl:ENSRNOG00000030019 AllianceGenome:RGD:2167
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nkaa1b
Summary: Enables several functions, including adenyl ribonucleotide binding activity; alkali metal ion binding activity; and ankyrin binding activity. Involved in several processes, including cellular response to mechanical stimulus; inorganic cation transmembrane transport; and membrane hyperpolarization. Located in several cellular components, including T-tubule; basolateral plasma membrane; and intercalated disc. Part of sodium:potassium-exchanging ATPase complex. Used to study hypertension. Biomarker of hyperhomocysteinemia and sensorineural hearing loss. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2DD. Orthologous to human ATP1A1 (ATPase Na+/K+ transporting subunit alpha 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 7293.3), Heart (RPKM 1410.6) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (191709311..191737414, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (189020722..189048826, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (204003742..204032023, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Evidence That Binding of Cyclic GMP to the Extracellular Domain of NKA (Sodium-Potassium ATPase) Mediates Natriuresis.
Title: Evidence That Binding of Cyclic GMP to the Extracellular Domain of NKA (Sodium-Potassium ATPase) Mediates Natriuresis.
Super-resolution microscopy reveals that Na(+)/K(+)-ATPase signaling protects against glucose-induced apoptosis by deactivating Bad.
Title: Super-resolution microscopy reveals that Na(+)/K(+)-ATPase signaling protects against glucose-induced apoptosis by deactivating Bad.
Mechanism of Na-K-ATPase Inhibition by PGE2 in Intestinal Epithelial Cells.
Title: Mechanism of Na-K-ATPase Inhibition by PGE2 in Intestinal Epithelial Cells.
Chronic Ouabain Prevents Na,K-ATPase Dysfunction and Targets AMPK and IL-6 in Disused Rat Soleus Muscle.
Title: Chronic Ouabain Prevents Na,K-ATPase Dysfunction and Targets AMPK and IL-6 in Disused Rat Soleus Muscle.
Expression of Atp1a1 is lowered in the renal tissue of irradiated rats.
Title: Alteration of renal Na,K-ATPase in rats following the mediastinal γ-irradiation.
These data indicate that as enterocytes mature from crypt-like to villus-like in culture, the functional activity of Na-K-ATPase increases secondary to altered affinity of the alpha1 subunit to extracellular K(+), in order to accommodate the functional preference of the intestinal cell type.
Title: Unique Regulation of Na-K-ATPase during Growth and Maturation of Intestinal Epithelial Cells.
Report structural requirements for the Na-K-ATPase to function as a Src-dependent receptor and provide strong evidence of isoform-specific Src interaction involving the identified key amino acids.
Title: Heterogeneity of signal transduction by Na-K-ATPase α-isoforms: role of Src interaction.
the effects of AdenosylMethionine on redox homeostasis and on the activity of Na(+), K(+)-ATPase in the cerebral cortex of young rats, was studied.
Title: S-Adenosylmethionine Promotes Oxidative Stress and Decreases Na(+), K(+)-ATPase Activity in Cerebral Cortex Supernatants of Adolescent Rats: Implications for the Pathogenesis of S-Adenosylhomocysteine Hydrolase Deficiency.
Higher thick ascending limg Na(+)-K(+)-ATPase activity contributes to relationships between whole body mass-specific metabolic rate and high urine concentrating.
Title: Body mass-specific Na(+)-K(+)-ATPase activity in the medullary thick ascending limb: implications for species-dependent urine concentrating mechanisms.
An antibody against the extracellular DR region (897-911) of Na(+)-K(+)-ATPase subunit alpha 1 disrupted the Na+-K+-ATPase/ROS amplifier and protected cultured cardiomyocytes from ROS-induced injury.
Title: Activation of Na(+)-K(+)-ATPase with DRm217 attenuates oxidative stress-induced myocardial cell injury via closing Na(+)-K(+)-ATPase/Src/Ros amplifier.

Submit: New GeneRIF Correction See all GeneRIFs (106)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D2Mgh11 (e-PCR)
- UniSTS:119581

Atp1a1 (e-PCR), detects polymorphism
- UniSTS:546665

D2Wox26 (e-PCR)
- UniSTS:119238

A001Z44 (e-PCR)
- UniSTS:66284

D2Arb18 (e-PCR), detects polymorphism
- UniSTS:227316

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ADP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase binding	ISO Inferred from Sequence Orthology more info
enables P-type potassium transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables P-type sodium:potassium-exchanging transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables P-type sodium:potassium-exchanging transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables P-type sodium:potassium-exchanging transporter activity	IEA Inferred from Electronic Annotation more info
enables P-type sodium:potassium-exchanging transporter activity	ISO Inferred from Sequence Orthology more info
enables ankyrin binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatase activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol 3-kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables potassium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables potassium ion binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-folding chaperone binding	IDA Inferred from Direct Assay more info	PubMed
enables protein-folding chaperone binding	IEA Inferred from Electronic Annotation more info
enables protein-folding chaperone binding	ISO Inferred from Sequence Orthology more info
enables sodium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables sodium ion binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables sodium ion binding	ISO Inferred from Sequence Orthology more info
enables steroid hormone binding	IEA Inferred from Electronic Annotation more info
enables steroid hormone binding	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cardiac muscle contraction	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to mechanical stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to steroid hormone stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to steroid hormone stimulus	ISO Inferred from Sequence Orthology more info
involved_in energy coupled proton transmembrane transport, against electrochemical gradient	TAS Traceable Author Statement more info	PubMed
involved_in establishment or maintenance of transmembrane electrochemical gradient	IC Inferred by Curator more info	PubMed
involved_in establishment or maintenance of transmembrane electrochemical gradient	IEA Inferred from Electronic Annotation more info
involved_in heart contraction	IEA Inferred from Electronic Annotation more info
acts_upstream_of heart contraction	ISO Inferred from Sequence Orthology more info
involved_in intracellular potassium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular potassium ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular potassium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular sodium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular sodium ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular sodium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in membrane hyperpolarization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane repolarization	IEA Inferred from Electronic Annotation more info
involved_in membrane repolarization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glucocorticoid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of glucocorticoid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of heart contraction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of heart contraction	ISO Inferred from Sequence Orthology more info
involved_in osmosensory signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in osmosensory signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of heart contraction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of heart contraction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of striated muscle contraction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of striated muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in potassium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in potassium ion import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in potassium ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in proton transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of blood pressure	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in regulation of cardiac muscle cell contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of sodium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of the force of heart contraction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of the force of heart contraction	ISO Inferred from Sequence Orthology more info
involved_in relaxation of cardiac muscle	TAS Traceable Author Statement more info	PubMed
involved_in response to glycoside	IEA Inferred from Electronic Annotation more info
NOT involved_in response to glycoside	ISO Inferred from Sequence Orthology more info
involved_in response to glycoside	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in sodium ion export across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion export across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in sodium ion export across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in sodium ion export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in sodium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in T-tubule	IDA Inferred from Direct Assay more info	PubMed
located_in T-tubule	IEA Inferred from Electronic Annotation more info
located_in T-tubule	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in axon	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in caveola	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in intercalated disc	IDA Inferred from Direct Assay more info	PubMed
located_in lateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in melanosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in organelle membrane	IEA Inferred from Electronic Annotation more info
located_in organelle membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
is_active_in sarcolemma	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed
located_in sarcolemma	ISO Inferred from Sequence Orthology more info
part_of sodium:potassium-exchanging ATPase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of sodium:potassium-exchanging ATPase complex	IDA Inferred from Direct Assay more info	PubMed
part_of sodium:potassium-exchanging ATPase complex	IEA Inferred from Electronic Annotation more info
part_of sodium:potassium-exchanging ATPase complex	ISO Inferred from Sequence Orthology more info
located_in sperm flagellum	IEA Inferred from Electronic Annotation more info
located_in sperm flagellum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sodium/potassium-transporting ATPase subunit alpha-1

Names: ATPase, Na+/K+ transporting, alpha 1 polypeptide; ATPase, Na+K+ transporting, alpha 1; Na(+)/K(+) ATPase alpha-1 subunit; sodium pump subunit alpha-1

NP_036636.1

EC 7.2.2.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012504.1 → NP_036636.1 sodium/potassium-transporting ATPase subunit alpha-1 precursor

See identical proteins and their annotated locations for NP_036636.1

Status: VALIDATED

Source sequence(s)

M14511

UniProtKB/Swiss-Prot

P06685, Q64609

UniProtKB/TrEMBL

A0A8I5Y5B0

Related

ENSRNOP00000045650.4, ENSRNOT00000040430.5

Conserved Domains (6) summary

smart00831
Location:40 → 114

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

COG4087
Location:606 → 732

COG4087; Soluble P-type ATPase [General function prediction only]

TIGR01106
Location:29 → 1023

ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit

pfam00122
Location:134 → 365

E1-E2_ATPase; E1-E2 ATPase

pfam00689
Location:799 → 1008

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam13246
Location:427 → 521

Cation_ATPase; Cation transport ATPase (P-type)