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CTC_RS14060 tetanus toxin [ Clostridium tetani E88 ]

Gene ID: 24255210, updated on 14-Aug-2019

Summary

Gene symbol
CTC_RS14060
Gene description
tetanus toxin
Locus tag
CTC_RS14060
Gene type
protein coding
Organism
Clostridium tetani E88 (strain: Massachusetts, substrain: E88)
Lineage
Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae; Clostridium
Old locus tag
pE88_60

Genomic context

Location:
plasmid: pE88
Sequence:
NC_004565.1 (68640..72587, complement)

NC_004565.1Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene transcriptional regulator BotR, P-21 Neighboring gene hypothetical protein

Pathways from BioSystems

  • Disease, organism-specific biosystem (from REACTOME)
    Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
  • Infectious disease, organism-specific biosystem (from REACTOME)
    Infectious disease, organism-specific biosystem
    Infectious disease
  • Neurotoxicity of clostridium toxins, organism-specific biosystem (from REACTOME)
    Neurotoxicity of clostridium toxins, organism-specific biosystemClostridial neurotoxins, when taken up by human neurons, block synaptic transmission by cleaving proteins required for the fusion of synaptic vesicles with the plasma membrane. They are remarkably ef...
  • Toxicity of tetanus toxin (TeNT), organism-specific biosystem (from REACTOME)
    Toxicity of tetanus toxin (TeNT), organism-specific biosystemTetanus toxin (TeNT), a disulfide-bonded heavy chain (HC) - light chain (LC) dimer, is secreted from bacteria growing in an infected wound directly into the circulation. Circulating toxin molecules a...
  • Uptake and actions of bacterial toxins, organism-specific biosystem (from REACTOME)
    Uptake and actions of bacterial toxins, organism-specific biosystemThe toxic effects of many bacteria on their human hosts are mediated by proteins released from the bacteria that enter human cells and disrupt critical cellular functions (Henkel et al. 2010). All of...

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004565.1 Reference assembly

    Range
    68640..72587 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. WP_011100836.1 Peptide Sequence

    See identical proteins and their annotated locations for WP_011100836.1

    UniProtKB/Swiss-Prot
    P04958
    Conserved Domains (4) summary
    pfam07951
    Location:11051314
    Toxin_R_bind_C; Clostridium neurotoxin, C-terminal receptor binding
    pfam01742
    Location:3419
    Peptidase_M27; Clostridial neurotoxin zinc protease
    pfam07952
    Location:559880
    Toxin_trans; Clostridium neurotoxin, Translocation domain
    pfam07953
    Location:8931096
    Toxin_R_bind_N; Clostridium neurotoxin, N-terminal receptor binding
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