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Pramel12 PRAME like 12 [ Mus musculus (house mouse) ]

Gene ID: 242736, updated on 27-Feb-2024

Summary

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Official Symbol
Pramel12provided by MGI
Official Full Name
PRAME like 12provided by MGI
Primary source
MGI:MGI:2140473
See related
Ensembl:ENSMUSG00000046862 AllianceGenome:MGI:2140473
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pramef8; 4732496O08Rik
Summary
Predicted to enable ubiquitin ligase-substrate adaptor activity. Predicted to be part of Cul2-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to several human genes including PRAMEF1 (PRAME family member 1); PRAMEF10 (PRAME family member 10); and PRAMEF11 (PRAME family member 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 3.7), limb E14.5 (RPKM 3.2) and 28 other tissues See more
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Genomic context

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Location:
4 E1; 4 77.65 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (143137457..143147661)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (143412155..143421091)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene Bacidic (leucine-rich) nuclear phosphoprotein 32 family, member B, pseudogene 1 Neighboring gene PRAME like 1 Neighboring gene STARR-seq mESC enhancer starr_11972 Neighboring gene oogenesin 4 Neighboring gene KH-type splicing regulatory protein pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  2. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
PRAME family member 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355724.1 → NP_001342653.1  PRAME family member 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK029142, BC056931, BQ745938
    Consensus CDS
    CCDS38944.1
    UniProtKB/TrEMBL
    Q8CE24
    Related
    ENSMUSP00000041323.8, ENSMUST00000037356.8
    Conserved Domains (2) summary
    sd00033
    Location:251 → 271
    LRR_RI; leucine-rich repeat [structural motif]
    cl12013
    Location:238 → 338
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  2. NM_172877.3 → NP_766465.1  PRAME family member 8

    See identical proteins and their annotated locations for NP_766465.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK029142, BC056931
    Consensus CDS
    CCDS38944.1
    UniProtKB/TrEMBL
    Q8CE24
    Related
    ENSMUSP00000058676.4, ENSMUST00000059790.11
    Conserved Domains (2) summary
    sd00033
    Location:251 → 271
    LRR_RI; leucine-rich repeat [structural motif]
    cl12013
    Location:238 → 338
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    143137457..143147661
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538857.5 → XP_006538920.1  PRAME family member 8 isoform X1

    See identical proteins and their annotated locations for XP_006538920.1

    UniProtKB/TrEMBL
    Q8CE24
    Conserved Domains (2) summary
    sd00033
    Location:251 → 271
    LRR_RI; leucine-rich repeat [structural motif]
    cl12013
    Location:238 → 338
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
Nucleotide Protein Strain
Heading Accession and Version

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