Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cyp2a3provided by RGD
Official Full Name: cytochrome P450, family 2, subfamily a, polypeptide 3provided by RGD
Primary source: RGD:2465
See related: Ensembl:ENSRNOG00000068556 AllianceGenome:RGD:2465
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cyp2a3a; RATCYP2A3A
Summary: Predicted to enable heme binding activity and monooxygenase activity. Predicted to be involved in coumarin metabolic process; epoxygenase P450 pathway; and xenobiotic metabolic process. Predicted to act upstream of or within cellular response to cadmium ion; heme metabolic process; and response to stilbenoid. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in nicotine dependence and warfarin resistance. Orthologous to human CYP2A13 (cytochrome P450 family 2 subfamily A member 13); CYP2A6 (cytochrome P450 family 2 subfamily A member 6); and CYP2A7 (cytochrome P450 family 2 subfamily A member 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 289.0), Liver (RPKM 51.2) and 1 other tissue See more
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Genomic context

Location:: 1q21

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (91299584..91307650)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (82171914..82179980)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (83653248..83662118)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CYP2A3 levels in the rat esophagus can be a determinant of its ability to metabolize carcinogen N-nitrosomethylbenzylamine in vivo
Title: Functional role of cytochrome p-450 2a3 in N-nitrosomethylbenzylamine metabolism in rat esophagus.
CYP2a3 trans activation requires NFIA transcription factors
Title: Transcriptional regulation of rat CYP2A3 by nuclear factor 1: identification of a novel NFI-A isoform, and evidence for tissue-selective interaction of NFI with the CYP2A3 promoter in vivo.

Submit: New GeneRIF Correction

General gene information

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Markers

RH127774 (e-PCR)
- UniSTS:211084

Cyp2a4 (e-PCR), detects polymorphism
- UniSTS:462989

D1Wox16 (e-PCR)
- UniSTS:117944

d1mgh28 (e-PCR)
- UniSTS:120252

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables arachidonic acid epoxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aromatase activity	IEA Inferred from Electronic Annotation more info
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	TAS Traceable Author Statement more info	PubMed
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IEA Inferred from Electronic Annotation more info
enables oxygen binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in coumarin metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in epoxygenase P450 pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to stilbenoid	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cytochrome P450 2A3

Names: CYPIIA3; coumarin 7-hydroxylase; cytochrome P450, family 2, subfamily A, polypeptide 3a; cytochrome P450, subfamily IIA (phenobarbital-inducble)/ (cytochrome P450 IIA3)

NP_036674.1

EC 1.14.14.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.