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Dbp D-box binding PAR bZIP transcription factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 24309, updated on 30-Sep-2021

Summary

Official Symbol
Dbpprovided by RGD
Official Full Name
D-box binding PAR bZIP transcription factorprovided by RGD
Primary source
RGD:2491
See related
EnsemblRapid:ENSRNOG00000021027
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
The protein encoded by this gene is a member of the Par bZIP transcription factor family and binds to specific sequences in the promoters of several genes, such as albumin, Cyp2a4, and Cyp2a5. The encoded protein can bind DNA as a homo- or heterodimer and is involved in the regulation of some circadian rhythym genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]
Expression
Biased expression in Adrenal (RPKM 456.4), Heart (RPKM 246.8) and 9 other tissues See more
Orthologs
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Genomic context

See Dbp in Genome Data Viewer
Location:
1q22
Exon count:
4
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (96175796..96180745)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (101687896..101692845)

Chromosome 1 - NC_051336.1Genomic Context describing neighboring genes Neighboring gene secretory blood group 1 Neighboring gene netrin 5 Neighboring gene carbonic anhydrase 11 Neighboring gene sphingosine kinase 2 Neighboring gene ribosomal protein L18

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Clone Names

  • MGC105474

Gene Ontology Provided by RGD

Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
D site-binding protein
Names
D site albumin promoter binding protein
D site of albumin promoter (albumin D-box) binding protein
albumin D box-binding protein
albumin D-element-binding protein
d site albumin promoter-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289982.1NP_001276911.1  D site-binding protein isoform 2

    See identical proteins and their annotated locations for NP_001276911.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    JACYVU010000033
    UniProtKB/TrEMBL
    Q6R2I3
    Conserved Domains (1) summary
    cd14695
    Location:154213
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain
  2. NM_001289983.1NP_001276912.1  D site-binding protein isoform 3

    See identical proteins and their annotated locations for NP_001276912.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    JACYVU010000033
    UniProtKB/TrEMBL
    Q6R2I2
    Conserved Domains (1) summary
    cd14695
    Location:117176
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain
  3. NM_012543.3NP_036675.1  D site-binding protein isoform 1

    See identical proteins and their annotated locations for NP_036675.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    JACYVU010000033
    UniProtKB/Swiss-Prot
    P16443
    Related
    ENSRNOP00000028547.2, ENSRNOT00000028546.6
    Conserved Domains (1) summary
    cd14695
    Location:254313
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051336.1 Reference mRatBN7.2 Primary Assembly

    Range
    96175796..96180745
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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