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Cela1 chymotrypsin like elastase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24331, updated on 13-Apr-2024

Summary

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Official Symbol
Cela1provided by RGD
Official Full Name
chymotrypsin like elastase 1provided by RGD
Primary source
RGD:2547
See related
Ensembl:ENSRNOG00000031930 AllianceGenome:RGD:2547
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ela1; ELAI1; RATELAI1
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within several processes, including elastin catabolic process; pancreas development; and regulation of transcription by RNA polymerase II. Predicted to be active in extracellular space. Orthologous to human CELA1 (chymotrypsin like elastase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 4069.6) and Liver (RPKM 1220.4) See more
Orthologs
human mouse all
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Genomic context

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Location:
7q36
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (133651939..133665136, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (131773161..131786300, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (142305337..142318621, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene DAZ associated protein 2 Neighboring gene small cell adhesion glycoprotein Neighboring gene bridging integrator 2 Neighboring gene uncharacterized LOC134479578 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 6 Neighboring gene solute carrier family 4 member 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Elastase involvement in extracellular and intracellular collagen degradation during postpartum involution of the uterus. Ryvnyak VV, et al. Bull Exp Biol Med, 2003 Aug. PMID 14631512
  2. Isolation and characterization of rat pancreatic elastase. Largman C. Biochemistry, 1983 Aug 2. PMID 6555050
  3. Electron-histochemical location of cathepsin D and elastase in the uterus. Ryvnyak VV, et al. Bull Exp Biol Med, 2003 Aug. PMID 14631510
  4. Primary structure of two distinct rat pancreatic preproelastases determined by sequence analysis of the complete cloned messenger ribonucleic acid sequences. MacDonald RJ, et al. Biochemistry, 1982 Mar 16. PMID 6918221
  5. Structure of the two related elastase genes expressed in the rat pancreas. Swift GH, et al. J Biol Chem, 1984 Nov 25. PMID 6094548

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results describe the location of elastase in rat uterus during its postpartum involution.
    Title: Elastase involvement in extracellular and intracellular collagen degradation during postpartum involution of the uterus.
  2. Data show that both cathepsin D and elastase are present in lysosomes of smooth-muscle cells, macrophages, and fibroblasts of the myometrium.
    Title: Electron-histochemical location of cathepsin D and elastase in the uterus.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phospholipid binding IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables serine-type endopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cell chemotaxis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within digestive system development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within elastin catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within exocrine pancreas development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within inflammatory response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within multicellular organism growth ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within pancreas morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in phagocytosis, engulfment IEA
Inferred from Electronic Annotation
more info
  
involved_in plasma membrane tubulation IEA
Inferred from Electronic Annotation
more info
  
involved_in podosome assembly IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within post-embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within tissue remodeling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in phagocytic cup IEA
Inferred from Electronic Annotation
more info
  
located_in podosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
chymotrypsin-like elastase family member 1
Names
chymotrypsin-like elastase family, member 1
elastase 1, pancreatic
elastase-1
NP_036684.1
XP_063119047.1
XP_063119048.1
XP_063119049.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012552.4 → NP_036684.1  chymotrypsin-like elastase family member 1 precursor

    See identical proteins and their annotated locations for NP_036684.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    P00773
    UniProtKB/TrEMBL
    A0A0G2JSI5, A6KCL6
    Related
    ENSRNOP00000006351.4, ENSRNOT00000006351.7
    Conserved Domains (2) summary
    smart00020
    Location:26 → 258
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:27 → 262
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    133651939..133665136 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063262978.1 → XP_063119048.1  chymotrypsin-like elastase family member 1 isoform X2

  2. XM_063262977.1 → XP_063119047.1  chymotrypsin-like elastase family member 1 isoform X1

  3. XM_063262979.1 → XP_063119049.1  chymotrypsin-like elastase family member 1 isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P00773.1 GenPept UniProtKB/Swiss-Prot:P00773

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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Chemical Information
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