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Gimap8 GTPase, IMAP family member 8 [ Mus musculus (house mouse) ]

Gene ID: 243374, updated on 11-Apr-2024

Summary

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Official Symbol
Gimap8provided by MGI
Official Full Name
GTPase, IMAP family member 8provided by MGI
Primary source
MGI:MGI:2685303
See related
Ensembl:ENSMUSG00000064262 AllianceGenome:MGI:2685303
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IAN9; Gm457; IMAP8
Summary
This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. The encoded protein is larger than the other gene family members and includes three AIG1 domains (corresponding to the AIG1 protein from Arabidopsis thaliana) whereas other family members have one AIG1 domain. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. [provided by RefSeq, Jul 2008]
Expression
Broad expression in spleen adult (RPKM 7.3), thymus adult (RPKM 6.4) and 16 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 B2.3; 6 23.62 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (48624120..48637809)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (48647186..48660875)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 775 Neighboring gene predicted gene, 38804 Neighboring gene expressed sequence AI854703 Neighboring gene STARR-positive B cell enhancer ABC_E9664 Neighboring gene predicted gene, 44262 Neighboring gene predicted gene, 46958 Neighboring gene GTPase, IMAP family member 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Malaria-suppressible expression of the anti-apoptotic triple GTPase mGIMAP8. Krücken J, et al. J Cell Biochem, 2005 Oct 1. PMID 16088918
  2. Generation and characterisation of mice deficient in the multi-GTPase domain containing protein, GIMAP8. Webb LM, et al. PLoS One, 2014. PMID 25329815, Free PMC Article
  3. IAN family critically regulates survival and development of T lymphocytes. Nitta T, et al. PLoS Biol, 2006 Apr. PMID 16509771, Free PMC Article
  4. Comparative analysis of the human gimap gene cluster encoding a novel GTPase family. Krücken J, et al. Gene, 2004 Oct 27. PMID 15474311
  5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GIMAP8 exerts an anti-apoptotic effect in the immune system and is involved in responses to infections
    Title: Malaria-suppressible expression of the anti-apoptotic triple GTPase mGIMAP8.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within regulation of T cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
GTPase IMAP family member 8
Names
immune-associated nucleotide-binding protein 9
immunity-associated protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077410.1 → NP_001070878.1  GTPase IMAP family member 8 isoform 1

    See identical proteins and their annotated locations for NP_001070878.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longest transcript. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AA289616, AB178029, AK134199, BB033818, BE456621
    Consensus CDS
    CCDS20108.1
    UniProtKB/Swiss-Prot
    Q3UZ12, Q75N62
    Related
    ENSMUSP00000145286.2, ENSMUST00000203083.3
    Conserved Domains (1) summary
    cd01852
    Location:49 → 248
    AIG1; AvrRpt2-Induced Gene 1 (AIG1)

  2. NM_001286629.1 → NP_001273558.1  GTPase IMAP family member 8 isoform 2

    See identical proteins and their annotated locations for NP_001273558.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region resulting in a frameshift and an early stop codon, compared to variant 2. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC154013
    Consensus CDS
    CCDS85043.1
    UniProtKB/TrEMBL
    A0A0R3P9C7
    Related
    ENSMUSP00000077350.5, ENSMUST00000078223.6
    Conserved Domains (1) summary
    cd01852
    Location:49 → 248
    AIG1; AvrRpt2-Induced Gene 1 (AIG1)

  3. NM_212486.2 → NP_997651.1  GTPase IMAP family member 8 isoform 1

    See identical proteins and their annotated locations for NP_997651.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AA289616, AB178029, BB033818, BE456621
    Consensus CDS
    CCDS20108.1
    UniProtKB/Swiss-Prot
    Q3UZ12, Q75N62
    Related
    ENSMUSP00000145255.2, ENSMUST00000203509.2
    Conserved Domains (1) summary
    cd01852
    Location:49 → 248
    AIG1; AvrRpt2-Induced Gene 1 (AIG1)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    48624120..48637809
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506079.3 → XP_006506142.1  GTPase IMAP family member 8 isoform X1

    See identical proteins and their annotated locations for XP_006506142.1

    UniProtKB/TrEMBL
    A0A0R3P9C7
    Conserved Domains (1) summary
    cd01852
    Location:49 → 248
    AIG1; AvrRpt2-Induced Gene 1 (AIG1)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q75N62.1 GenPept UniProtKB/Swiss-Prot:Q75N62

Gene LinkOut

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