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Fancc FA complementation group C [ Rattus norvegicus (Norway rat) ]

Gene ID: 24361, updated on 5-Jun-2021

Summary

Symbol
Fanccprovided by RGD
Full Name
FA complementation group Cprovided by RGD
Primary source
RGD:2593
See related
Ensembl:ENSRNOG00000016889
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Facc
Summary
human homolog is a component of the Fanconi anemia core protein complex, which may play a role in DNA repair [RGD, Feb 2006]
Expression
Biased expression in Kidney (RPKM 46.8), Thymus (RPKM 44.9) and 9 other tissues See more
Orthologs
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Genomic context

See Fancc in Genome Data Viewer
Location:
17p14
Exon count:
21
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (1680660..1822610)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (826512..955703, complement)

Chromosome 17 - NC_051352.1Genomic Context describing neighboring genes Neighboring gene patched 1 Neighboring gene small nucleolar RNA SNORA76 Neighboring gene microRNA 3074 Neighboring gene microRNA 24-1 Neighboring gene microRNA 27b Neighboring gene microRNA 23b Neighboring gene aminopeptidase O Neighboring gene uncharacterized LOC102551048 Neighboring gene fructose-bisphosphatase 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in brain morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within brain morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within gamete generation ISO
Inferred from Sequence Orthology
more info
 
involved_in germ cell development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within germ cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in interstrand cross-link repair IEA
Inferred from Electronic Annotation
more info
 
involved_in myeloid cell homeostasis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within myeloid cell homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in neuronal stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neuronal stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
 
involved_in nucleotide-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nucleotide-excision repair IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within nucleotide-excision repair ISO
Inferred from Sequence Orthology
more info
 
involved_in removal of superoxide radicals IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within removal of superoxide radicals ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of Fanconi anaemia nuclear complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of Fanconi anaemia nuclear complex IEA
Inferred from Electronic Annotation
more info
 
part_of Fanconi anaemia nuclear complex ISO
Inferred from Sequence Orthology
more info
 
part_of Fanconi anaemia nuclear complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
Fanconi anemia group C protein homolog
Names
Fanconi anemia, complementation group C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012557.2NP_036689.2  Fanconi anemia group C protein homolog

    See identical proteins and their annotated locations for NP_036689.2

    Status: PROVISIONAL

    Source sequence(s)
    BC168147
    UniProtKB/TrEMBL
    B4F762
    Related
    ENSRNOP00000022884.4, ENSRNOT00000022884.6
    Conserved Domains (1) summary
    pfam02106
    Location:10554
    Fanconi_C; Fanconi anaemia group C protein

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051352.1 Reference mRatBN7.2 Primary Assembly

    Range
    1680660..1822610
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039095340.1XP_038951268.1  Fanconi anemia group C protein homolog isoform X1

    Conserved Domains (1) summary
    pfam02106
    Location:33577
    Fanconi_C; Fanconi anaemia group C protein
  2. XM_006253489.4XP_006253551.1  Fanconi anemia group C protein homolog isoform X2

    See identical proteins and their annotated locations for XP_006253551.1

    UniProtKB/TrEMBL
    B4F762
    Conserved Domains (1) summary
    pfam02106
    Location:10554
    Fanconi_C; Fanconi anaemia group C protein
  3. XM_008771423.3XP_008769645.1  Fanconi anemia group C protein homolog isoform X4

    Conserved Domains (1) summary
    pfam02106
    Location:1457
    Fanconi_C; Fanconi anaemia group C protein
  4. XM_039095341.1XP_038951269.1  Fanconi anemia group C protein homolog isoform X5

    Conserved Domains (1) summary
    pfam02106
    Location:1379
    Fanconi_C; Fanconi anaemia group C protein
  5. XM_006253488.4XP_006253550.1  Fanconi anemia group C protein homolog isoform X1

    Conserved Domains (1) summary
    pfam02106
    Location:33577
    Fanconi_C; Fanconi anaemia group C protein
  6. XM_006253491.4XP_006253553.1  Fanconi anemia group C protein homolog isoform X3

    Conserved Domains (1) summary
    pfam02106
    Location:24463
    Fanconi_C; Fanconi anaemia group C protein

RNA

  1. XR_005495234.1 RNA Sequence

  2. XR_005495235.1 RNA Sequence

  3. XR_001841732.2 RNA Sequence

  4. XR_005495236.1 RNA Sequence

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