Slc6a11 solute carrier family 6 (neurotransmitter transporter, GABA), member 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc6a11provided by MGI
Official Full Name: solute carrier family 6 (neurotransmitter transporter, GABA), member 11provided by MGI
Primary source: MGI:MGI:95630
See related: Ensembl:ENSMUSG00000030307 AllianceGenome:MGI:95630
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GAT4; Gat3; Gabt4; D930045G19Rik; E130202I16Rik
Summary: Predicted to enable gamma-aminobutyric acid:sodium symporter activity and neurotransmitter binding activity. Involved in neurotransmitter uptake. Is active in synapse. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and liver and biliary system. Orthologous to human SLC6A11 (solute carrier family 6 member 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in frontal lobe adult (RPKM 78.6), cerebellum adult (RPKM 49.6) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 E3; 6 52.98 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (114108202..114226847)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (114131241..114249886)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model.
Title: GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model.
glial GAT-3 transporters are downregulated while neuronal GAT-1 function remains normal in dopamine-depleted rodents.
Title: GAT-3 Dysfunction Generates Tonic Inhibition in External Globus Pallidus Neurons in Parkinsonian Rodents.
We propose that enhancing GAT3-mediated uptake dampens tonic inhibition and promotes functional recovery after stroke
Title: GAT3 selective substrate l-isoserine upregulates GAT3 expression and increases functional recovery after a focal ischemic stroke in mice.
the expression of inhibitory neurotransmitter transporters GlyT1, GAT-1, and GAT-3 in inferior colliculus and hippocampus astrocytes, was examined.
Title: Expression of functional inhibitory neurotransmitter transporters GlyT1, GAT-1, and GAT-3 by astrocytes of inferior colliculus and hippocampus.
Development of GABA-removal system and its relationship to development of GABAergic networks studied by examination of changes in GAT-1 and GAT-3 expression and localization in embryonic and postnatal mouse spinal cord
Title: Characteristic development of the GABA-removal system in the mouse spinal cord.
Astrocyte-like cells create a microenvironment in which their uniquely positioned GABA 4 transporters control the degree of GABA(A)R activation and the migration of neuronal precursors.
Title: GABA release and uptake regulate neuronal precursor migration in the postnatal subventricular zone.
When transfected into Xenopus, zinc is a potent inhibitor of GAT4 in the hippocampus.
Title: Zinc inhibition of gamma-aminobutyric acid transporter 4 (GAT4) reveals a link between excitatory and inhibitory neurotransmission.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3)
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc6a11 (e-PCR), detects polymorphism
- UniSTS:547355

Gabt4 (e-PCR), detects polymorphism
- UniSTS:143158

Gabt4 (e-PCR), detects polymorphism
- UniSTS:143159

D6Mit329 (e-PCR), detects polymorphism
- UniSTS:130883

Slc6a11 (e-PCR), detects polymorphism
- UniSTS:525659

D6Mit383 (e-PCR), detects polymorphism
- UniSTS:130935

Slc6a11 (e-PCR), detects polymorphism
- UniSTS:495998

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables amino acid binding	ISO Inferred from Sequence Orthology more info
enables amino acid:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables gamma-aminobutyric acid:sodium:chloride symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables gamma-aminobutyric acid:sodium:chloride symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables gamma-aminobutyric acid:sodium:chloride symporter activity	ISO Inferred from Sequence Orthology more info
enables monocarboxylic acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables symporter activity	IEA Inferred from Electronic Annotation more info
enables taurine:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in amino acid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in monocarboxylic acid transport	ISO Inferred from Sequence Orthology more info
involved_in neurotransmitter transport	ISO Inferred from Sequence Orthology more info
involved_in neurotransmitter uptake	IDA Inferred from Direct Assay more info	PubMed
involved_in neurotransmitter uptake	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter uptake	NAS Non-traceable Author Statement more info	PubMed
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in cell projection	IBA Inferred from Biological aspect of Ancestor more info
located_in cell projection	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: sodium- and chloride-dependent GABA transporter 3

Names: GAT-3; GAT-4; gamma-aminobutyric acid (GABA-A) transporter 4; sodium- and chloride-dependent GABA transporter 4; solute carrier family 6 member 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172890.3 → NP_766478.1 sodium- and chloride-dependent GABA transporter 3

See identical proteins and their annotated locations for NP_766478.1

Status: PROVISIONAL

Source sequence(s)

AC153587, AC155719

Consensus CDS

CCDS39597.1

UniProtKB/Swiss-Prot

P31650, Q8BWA7

UniProtKB/TrEMBL

Q8BKG0

Related

ENSMUSP00000032451.7, ENSMUST00000032451.9

Conserved Domains (1) summary

cd11508
Location:44 → 585

SLC6sbd_GAT3; Na(+)- and Cl(-)-dependent GABA transporter 3; solute-binding domain