Format

Send to:

Choose Destination

Fbp1 fructose-bisphosphatase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24362, updated on 5-Jun-2021

Summary

Official Symbol
Fbp1provided by RGD
Official Full Name
fructose-bisphosphatase 1provided by RGD
Primary source
RGD:2595
See related
Ensembl:ENSRNOG00000017597
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fdp
Summary
catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate in gluconeogenesis [RGD, Feb 2006]
Expression
Biased expression in Kidney (RPKM 3334.2), Liver (RPKM 2280.7) and 1 other tissue See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Fbp1 in Genome Data Viewer
Location:
17p14
Exon count:
8
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (2207271..2230076)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (396175..417480, complement)

Chromosome 17 - NC_051352.1Genomic Context describing neighboring genes Neighboring gene FA complementation group C Neighboring gene microRNA 23b Neighboring gene aminopeptidase O Neighboring gene uncharacterized LOC102551048 Neighboring gene zinc finger protein 431-like Neighboring gene zinc finger protein 431-like Neighboring gene fructose-bisphosphatase 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables AMP binding IEA
Inferred from Electronic Annotation
more info
 
enables AMP binding ISO
Inferred from Sequence Orthology
more info
 
enables AMP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables fructose 1,6-bisphosphate 1-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables fructose 1,6-bisphosphate 1-phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables fructose 1,6-bisphosphate 1-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables fructose 1,6-bisphosphate 1-phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables fructose 1,6-bisphosphate 1-phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables monosaccharide binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to drug IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to drug ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to drug ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to insulin stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to magnesium ion IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to magnesium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to magnesium ion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in fructose 1,6-bisphosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in fructose 6-phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in fructose 6-phosphate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in fructose 6-phosphate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in fructose 6-phosphate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in fructose 6-phosphate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in fructose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in gluconeogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in gluconeogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in gluconeogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in gluconeogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of Ras protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell growth ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of glycolytic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of glycolytic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of glycolytic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of gluconeogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of gluconeogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of gluconeogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in sucrose biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
fructose-1,6-bisphosphatase 1
Names
D-fructose-1,6-bisphosphate 1-phosphohydrolase 1
FBPase 1
Fructose-16- biphosphatase
fructose-1,6- biphosphatase 1
liver FBPase
NP_036690.2
XP_038951270.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012558.3NP_036690.2  fructose-1,6-bisphosphatase 1

    See identical proteins and their annotated locations for NP_036690.2

    Status: VALIDATED

    Source sequence(s)
    BC078894, BC078895
    UniProtKB/Swiss-Prot
    P19112
    Related
    ENSRNOP00000023685.5, ENSRNOT00000023685.6
    Conserved Domains (1) summary
    cd00354
    Location:18332
    FBPase; Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1, ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051352.1 Reference mRatBN7.2 Primary Assembly

    Range
    2207271..2230076
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039095342.1XP_038951270.1  fructose-1,6-bisphosphatase 1 isoform X1

    Conserved Domains (1) summary
    cd00354
    Location:1248
    FBPase; Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1, ...
Support Center