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Psg22 pregnancy-specific beta-1-glycoprotein 22 [ Mus musculus (house mouse) ]

Gene ID: 243862, updated on 30-Apr-2024

Summary

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Official Symbol
Psg22provided by MGI
Official Full Name
pregnancy-specific beta-1-glycoprotein 22provided by MGI
Primary source
MGI:MGI:1891354
See related
Ensembl:ENSMUSG00000044903 AllianceGenome:MGI:1891354
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
cea9
Summary
Enables syndecan binding activity. Acts upstream of or within positive regulation of angiogenesis and positive regulation of transforming growth factor beta production. Predicted to be located in extracellular region. Orthologous to human CEACAM4 (CEA cell adhesion molecule 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward placenta adult (RPKM 45.0) See more
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Genomic context

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See Psg22 in Genome Data Viewer
Location:
7 A3; 7 9.26 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (18451976..18461363)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (18718051..18727438)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene pregnancy-specific beta-1-glycoprotein 21 Neighboring gene pregnancy-specific beta-1-glycoprotein 20 Neighboring gene STARR-seq mESC enhancer starr_18172 Neighboring gene STARR-seq mESC enhancer starr_18173 Neighboring gene STARR-seq mESC enhancer starr_18174 Neighboring gene STARR-seq mESC enhancer starr_18175 Neighboring gene predicted gene, 24464 Neighboring gene synaptonemal complex protein 1, pseudogene 1 Neighboring gene pregnancy specific beta-1-glycoprotein 19

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Early expression of pregnancy-specific glycoprotein 22 (PSG22) by trophoblast cells modulates angiogenesis in mice. Blois SM, et al. Biol Reprod, 2012 Jun. PMID 22423048, Free PMC Article
  2. Mouse pregnancy-specific glycoproteins: tissue-specific expression and evidence of association with maternal vasculature. Wynne F, et al. Reproduction, 2006 Apr. PMID 16595723
  3. Effects of Pparγ1 deletion on late-stage murine embryogenesis and cells that undergo endocycle. Nakano T, et al. Dev Biol, 2021 Oct. PMID 34246625
  4. RAD21 cooperates with pluripotency transcription factors in the maintenance of embryonic stem cell identity. Nitzsche A, et al. PLoS One, 2011 May 12. PMID 21589869, Free PMC Article
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. expressed early in pregnancy with the ability to induce the secretion of proangiogenic factors in immune cell types, including uterine dendritic and NK cells
    Title: Early expression of pregnancy-specific glycoprotein 22 (PSG22) by trophoblast cells modulates angiogenesis in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC91102

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables syndecan binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within angiogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of cytokine production IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within female pregnancy IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of macrophage cytokine production IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of angiogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of cytokine production IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of macrophage cytokine production IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transforming growth factor beta production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of transforming growth factor beta production IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
pregnancy-specific glycoprotein 22
Names
carcinoembryonic antigen-related cell adhesion molecule 1 pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004152.3 → NP_001004152.1  pregnancy-specific glycoprotein 22 precursor

    See identical proteins and their annotated locations for NP_001004152.1

    Status: VALIDATED

    Source sequence(s)
    AC149065
    Consensus CDS
    CCDS20876.1
    UniProtKB/Swiss-Prot
    Q66JZ0, Q810J1
    UniProtKB/TrEMBL
    E9Q6J7
    Related
    ENSMUSP00000146795.2, ENSMUST00000208221.2
    Conserved Domains (2) summary
    smart00408
    Location:400 → 461
    IGc2; Immunoglobulin C-2 Type
    cd05774
    Location:36 → 140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    18451976..18461363
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242558.1 → XP_030098418.1  pregnancy-specific glycoprotein 22 isoform X2

    Conserved Domains (1) summary
    cd05774
    Location:75 → 179
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

  2. XM_017322233.1 → XP_017177722.1  pregnancy-specific glycoprotein 22 isoform X1

    Conserved Domains (2) summary
    smart00408
    Location:319 → 380
    IGc2; Immunoglobulin C-2 Type
    cd05774
    Location:75 → 179
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_019175.1: Suppressed sequence

    Description
    NG_019175.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q810J1.2 GenPept UniProtKB/Swiss-Prot:Q810J1

Gene LinkOut

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