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Lgi4 leucine-rich repeat LGI family, member 4 [ Mus musculus (house mouse) ]

Gene ID: 243914, updated on 21-Apr-2024

Summary

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Official Symbol
Lgi4provided by MGI
Official Full Name
leucine-rich repeat LGI family, member 4provided by MGI
Primary source
MGI:MGI:2180197
See related
Ensembl:ENSMUSG00000036560 AllianceGenome:MGI:2180197
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
clp; Lgil3
Summary
Involved in regulation of myelination. Acts upstream of or within adult locomotory behavior and neurogenesis. Located in extracellular space. Is expressed in several structures, including adipose tissue; alimentary system; nervous system; reproductive system; and sensory organ. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita-1 and childhood absence epilepsy. Orthologous to human LGI4 (leucine rich repeat LGI family member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in stomach adult (RPKM 10.9), bladder adult (RPKM 9.6) and 18 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 B1; 7 19.29 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (30758360..30770347)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (31058909..31070935)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38984 Neighboring gene FXYD domain-containing ion transport regulator 7 Neighboring gene FXYD domain-containing ion transport regulator 1 Neighboring gene FXYD domain-containing ion transport regulator 3 Neighboring gene predicted gene, 53358 Neighboring gene hepsin Neighboring gene STARR-positive B cell enhancer mm9_chr7:31896031-31896332

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Fxyd3 and Lgi4 expression in the adult mouse: a case of endogenous antisense expression. Runkel F, et al. Mamm Genome, 2003 Oct. PMID 14694902
  2. Evidence against altered forms of MAG in the dysmyelinated mouse mutant claw paw. Niemann S, et al. Mamm Genome, 1998 Nov. PMID 9799842
  3. The mouse mutation claw paw: forelimb deformity and delayed myelination throughout the peripheral nervous system. Henry EW, et al. J Hered, 1991 Jul-Aug. PMID 1652607
  4. Regional distribution of the leucine-rich glioma inactivated (LGI) gene family transcripts in the adult mouse brain. Herranz-Pérez V, et al. Brain Res, 2010 Jan 11. PMID 19833108
  5. The effect of the mouse mutation claw paw on myelination and nodal frequency in sciatic nerves. Koszowski AG, et al. J Neurosci, 1998 Aug 1. PMID 9671673, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Our results identify a new mechanism regulating enteric gliogenesis as well as novel functions for Lgi4 regulating the proliferation and maturation of glial lineage cells throughout the peripheral nervous system
    Title: Lgi4 promotes the proliferation and differentiation of glial lineage cells throughout the developing peripheral nervous system.
  2. lGI4 distribution in the vertical limb of the diagonal band and in putative hippocampal interneurons suggests that the function of these genes might be related to the generation of hippocampal theta rhythm.
    Title: Regional distribution of the leucine-rich glioma inactivated (LGI) gene family transcripts in the adult mouse brain.
  3. Fxyd3 and Lgi4 transcripts potentially form double-stranded RNA molecules in many cell types in vivo, which may impact on their respective expression
    Title: Fxyd3 and Lgi4 expression in the adult mouse: a case of endogenous antisense expression.
  4. the abnormalities observed in claw paw mice are attributable to the loss of Lgi4 function
    Title: The claw paw mutation reveals a role for Lgi4 in peripheral nerve development.
Submit: New GeneRIF Correction

Phenotypes

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Associated conditions

Description Tests
claw paw
GeneReviews: Not available

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1) 
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC107385

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within Schwann cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within adult locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within glial cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within glial cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within gliogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within gliogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within myelination IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within myelination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in myelination in peripheral nervous system IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within myelination in peripheral nervous system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neuron maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of myelination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of myelination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
leucine-rich repeat LGI family member 4
Names
LGI1-like protein 3
leucine-rich glioma inactivated protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419302.1 → NP_001406231.1  leucine-rich repeat LGI family member 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC149055, AC158993

  2. NM_144556.3 → NP_653139.2  leucine-rich repeat LGI family member 4 isoform 1 precursor

    See identical proteins and their annotated locations for NP_653139.2

    Status: VALIDATED

    Source sequence(s)
    AC149055, AC158993
    Consensus CDS
    CCDS21124.1
    UniProtKB/Swiss-Prot
    Q8K1S1, Q8K4Y8
    UniProtKB/TrEMBL
    Q3UYI9
    Related
    ENSMUSP00000041579.8, ENSMUST00000039775.9
    Conserved Domains (5) summary
    smart00082
    Location:158 → 206
    LRRCT; Leucine rich repeat C-terminal domain
    sd00031
    Location:54 → 77
    LRR_1; leucine-rich repeat [structural motif]
    pfam03736
    Location:396 → 438
    EPTP; EPTP domain
    pfam12799
    Location:102 → 140
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:76 → 136
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    30758360..30770347
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153096.1 → XP_036008989.1  leucine-rich repeat LGI family member 4 isoform X1

    UniProtKB/TrEMBL
    Q3UYI9
    Conserved Domains (4) summary
    TIGR00864
    Location:131 → 192
    PCC; polycystin cation channel protein
    sd00031
    Location:54 → 77
    LRR_1; leucine-rich repeat [structural motif]
    pfam03736
    Location:394 → 434
    EPTP; EPTP domain
    pfam13855
    Location:76 → 136
    LRR_8; Leucine rich repeat

  2. XM_011250576.4 → XP_011248878.1  leucine-rich repeat LGI family member 4 isoform X4

    Conserved Domains (3) summary
    TIGR00864
    Location:131 → 192
    PCC; polycystin cation channel protein
    sd00031
    Location:54 → 77
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:77 → 136
    LRR_8; Leucine rich repeat

  3. XM_006539958.5 → XP_006540021.2  leucine-rich repeat LGI family member 4 isoform X2

    See identical proteins and their annotated locations for XP_006540021.2

    UniProtKB/TrEMBL
    Q3UYI9
    Conserved Domains (4) summary
    TIGR00864
    Location:70 → 131
    PCC; polycystin cation channel protein
    sd00031
    Location:17 → 40
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:16 → 75
    LRR_8; Leucine rich repeat
    pfam03736
    Location:336 → 376
    EPTP; EPTP domain

  4. XM_036153097.1 → XP_036008990.1  leucine-rich repeat LGI family member 4 isoform X3

    Conserved Domains (1) summary
    pfam03736
    Location:162 → 202
    EPTP; EPTP domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K1S1.1 GenPept UniProtKB/Swiss-Prot:Q8K1S1

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