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Mctp2 multiple C2 domains, transmembrane 2 [ Mus musculus (house mouse) ]

Gene ID: 244049, updated on 5-Mar-2024

Summary

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Official Symbol
Mctp2provided by MGI
Official Full Name
multiple C2 domains, transmembrane 2provided by MGI
Primary source
MGI:MGI:2685335
See related
Ensembl:ENSMUSG00000032776 AllianceGenome:MGI:2685335
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm489
Summary
Predicted to enable calcium ion binding activity. Predicted to be involved in regulation of neurotransmitter secretion. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in synaptic vesicle membrane. Predicted to be integral component of membrane. Orthologous to human MCTP2 (multiple C2 and transmembrane domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 1.2), colon adult (RPKM 0.7) and 20 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 D1; 7 41.23 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (71727575..71956850, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (72077827..72307116, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930441H08 gene Neighboring gene RIKEN cDNA 1700011C11 gene Neighboring gene STARR-seq mESC enhancer starr_19150 Neighboring gene glycine cleavage system protein H (aminomethyl carrier) pseudogene Neighboring gene STARR-seq mESC enhancer starr_19151 Neighboring gene STARR-seq mESC enhancer starr_19152 Neighboring gene predicted gene, 36633 Neighboring gene STARR-seq mESC enhancer starr_19153 Neighboring gene STARR-seq mESC enhancer starr_19154 Neighboring gene predicted gene, 36696 Neighboring gene STARR-seq mESC enhancer starr_19156 Neighboring gene STARR-positive B cell enhancer ABC_E3727 Neighboring gene STARR-seq mESC enhancer starr_19157 Neighboring gene predicted gene, 39035 Neighboring gene STARR-seq mESC enhancer starr_19158 Neighboring gene STARR-seq mESC enhancer starr_19160 Neighboring gene ribosomal protein L17, pseudogene 10 Neighboring gene KAT8 regulatory NSL complex subunit 2, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Effect of expression alteration in flanking genes on phenotypes of St8sia2-deficient mice. Ikegami K, et al. Sci Rep, 2019 Sep 20. PMID 31541165, Free PMC Article
  2. A Role for Sensory end Organ-Derived Signals in Regulating Muscle Spindle Proprioceptor Phenotype. Wu D, et al. J Neurosci, 2019 May 29. PMID 30926747, Free PMC Article
  3. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of neurotransmitter secretion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
multiple C2 and transmembrane domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024703.1 → NP_001019874.1  multiple C2 and transmembrane domain-containing protein 2

    See identical proteins and their annotated locations for NP_001019874.1

    Status: PROVISIONAL

    Source sequence(s)
    BC086658
    Consensus CDS
    CCDS21361.1
    UniProtKB/Swiss-Prot
    Q5RJH2
    Related
    ENSMUSP00000078302.6, ENSMUST00000079323.8
    Conserved Domains (4) summary
    cd04042
    Location:195 → 314
    C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08376
    Location:357 → 469
    C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08377
    Location:509 → 627
    C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    pfam08372
    Location:771 → 824
    PRT_C; Plant phosphoribosyltransferase C-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    71727575..71956850 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242581.2 → XP_030098441.1  multiple C2 and transmembrane domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q5RJH2
    Conserved Domains (4) summary
    cd04042
    Location:195 → 314
    C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08376
    Location:357 → 469
    C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08377
    Location:509 → 627
    C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    pfam08372
    Location:771 → 824
    PRT_C; Plant phosphoribosyltransferase C-terminal

  2. XM_006540899.4 → XP_006540962.1  multiple C2 and transmembrane domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006540962.1

    UniProtKB/Swiss-Prot
    Q5RJH2
    Conserved Domains (4) summary
    cd04042
    Location:195 → 314
    C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08376
    Location:357 → 469
    C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08377
    Location:509 → 627
    C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    pfam08372
    Location:771 → 824
    PRT_C; Plant phosphoribosyltransferase C-terminal

  3. XM_006540901.2 → XP_006540964.1  multiple C2 and transmembrane domain-containing protein 2 isoform X2

    Conserved Domains (4) summary
    cd08376
    Location:170 → 282
    C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08377
    Location:322 → 440
    C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    pfam08372
    Location:584 → 637
    PRT_C; Plant phosphoribosyltransferase C-terminal
    cl14603
    Location:24 → 127
    C2; C2 domain

  4. XM_011250864.1 → XP_011249166.1  multiple C2 and transmembrane domain-containing protein 2 isoform X3

    Conserved Domains (3) summary
    cd08377
    Location:97 → 215
    C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    pfam08372
    Location:359 → 412
    PRT_C; Plant phosphoribosyltransferase C-terminal
    cl14603
    Location:1 → 57
    C2; C2 domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5RJH2.1 GenPept UniProtKB/Swiss-Prot:Q5RJH2

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