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Rgma repulsive guidance molecule family member A [ Mus musculus (house mouse) ]

Gene ID: 244058, updated on 23-Jun-2021

Summary

Official Symbol
Rgmaprovided by MGI
Official Full Name
repulsive guidance molecule family member Aprovided by MGI
Primary source
MGI:MGI:2679262
See related
Ensembl:ENSMUSG00000070509
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BC059072; C230063O06
Expression
Broad expression in whole brain E14.5 (RPKM 24.7), ovary adult (RPKM 23.2) and 23 other tissues See more
Orthologs
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Genomic context

See Rgma in Genome Data Viewer
Location:
7; 7 D1
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (73025268..73069647)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (73375520..73419899)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (80520406..80564785)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30075 Neighboring gene RIKEN cDNA 4930429H19 gene Neighboring gene RIKEN cDNA A730056A06 gene Neighboring gene predicted gene 44758 Neighboring gene chromodomain helicase DNA binding protein 2 Neighboring gene CRISPRi-validated cis-regulatory element for Chaserr and Chd2 Neighboring gene CHD2 adjacent suppressive regulatory RNA

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC38550, MGC69915

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables coreceptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables coreceptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferrin receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within BMP signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of axon regeneration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of collateral sprouting ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of neuron projection development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of receptor binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neural tube closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of membrane protein ectodomain proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of BMP signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
repulsive guidance molecule A
Names
RGM domain family, member A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177740.5NP_808408.2  repulsive guidance molecule A precursor

    See identical proteins and their annotated locations for NP_808408.2

    Status: VALIDATED

    Source sequence(s)
    BC059072
    Consensus CDS
    CCDS21362.2
    UniProtKB/Swiss-Prot
    Q6PCX7
    Related
    ENSMUSP00000091870.6, ENSMUST00000094312.12
    Conserved Domains (2) summary
    pfam06534
    Location:227410
    RGM_C; Repulsive guidance molecule (RGM) C-terminus
    pfam06535
    Location:48222
    RGM_N; Repulsive guidance molecule (RGM) N-terminus

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    73025268..73069647
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540902.2XP_006540965.1  repulsive guidance molecule A isoform X1

    See identical proteins and their annotated locations for XP_006540965.1

    UniProtKB/Swiss-Prot
    Q6PCX7
    Related
    ENSMUSP00000145758.2, ENSMUST00000139780.3
    Conserved Domains (2) summary
    pfam06534
    Location:211389
    RGM_C; Repulsive guidance molecule (RGM) C-terminus
    pfam06535
    Location:32206
    RGM_N; Repulsive guidance molecule (RGM) N-terminus
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