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Chd2 chromodomain helicase DNA binding protein 2 [ Mus musculus (house mouse) ]

Gene ID: 244059, updated on 23-Jun-2021

Summary

Official Symbol
Chd2provided by MGI
Official Full Name
chromodomain helicase DNA binding protein 2provided by MGI
Primary source
MGI:MGI:2448567
See related
Ensembl:ENSMUSG00000078671
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CHD-2; AI851092; BC029703; 2810013C04Rik; 2810040A01Rik; 5630401D06Rik
Expression
Ubiquitous expression in CNS E11.5 (RPKM 9.7), limb E14.5 (RPKM 9.5) and 28 other tissues See more
Orthologs
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Genomic context

See Chd2 in Genome Data Viewer
Location:
7; 7 D1
Exon count:
39
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (73076400..73191494, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (73426652..73541746, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (80571538..80686632, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930429H19 gene Neighboring gene RIKEN cDNA A730056A06 gene Neighboring gene repulsive guidance molecule family member A Neighboring gene predicted gene 44758 Neighboring gene CRISPRi-validated cis-regulatory element for Chaserr and Chd2 Neighboring gene CHD2 adjacent suppressive regulatory RNA Neighboring gene predicted gene, 30149 Neighboring gene predicted gene, 39036

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleosome-dependent ATPase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
chromodomain-helicase-DNA-binding protein 2
Names
ATP-dependent helicase CHD2
NP_001074814.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081345.2NP_001074814.2  chromodomain-helicase-DNA-binding protein 2

    See identical proteins and their annotated locations for NP_001074814.2

    Status: VALIDATED

    Source sequence(s)
    AC099699, AC154883
    Consensus CDS
    CCDS52274.1
    UniProtKB/Swiss-Prot
    E9PZM4
    Related
    ENSMUSP00000126352.3, ENSMUST00000169922.9
    Conserved Domains (7) summary
    cd00024
    Location:282344
    CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
    cd00046
    Location:503648
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00176
    Location:487768
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:790905
    Helicase_C; Helicase conserved C-terminal domain
    pfam00385
    Location:379447
    Chromo; Chromo (CHRromatin Organization MOdifier) domain
    pfam13907
    Location:14711553
    DUF4208; Domain of unknown function (DUF4208)
    pfam17104
    Location:10421165
    DUF5102; Domain of unknown function (DUF5102)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    73076400..73191494 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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