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FRK fyn related Src family tyrosine kinase [ Homo sapiens (human) ]

Gene ID: 2444, updated on 11-Apr-2024

Summary

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Official Symbol
FRKprovided by HGNC
Official Full Name
fyn related Src family tyrosine kinaseprovided by HGNC
Primary source
HGNC:HGNC:3955
See related
Ensembl:ENSG00000111816 MIM:606573; AllianceGenome:HGNC:3955
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GTK; RAK; PTK5
Summary
The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth. [provided by RefSeq, Jul 2008]
Expression
Broad expression in kidney (RPKM 3.0), duodenum (RPKM 2.8) and 23 other tissues See more
Orthologs
mouse all
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Genomic context

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See FRK in Genome Data Viewer
Location:
6q22.1
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (115931149..116100725, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (117114676..117284719, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (116252312..116382054, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2534 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:116049821-116050322 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:116210349-116211066 Neighboring gene uncharacterized LOC124901385 Neighboring gene NANOG hESC enhancer GRCh37_chr6:116235207-116235708 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24976 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24977 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24978 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_88040 Neighboring gene triosephosphate isomerase 1 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24979 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:116412309-116412554 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:116421676-116422198 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:116422199-116422719 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24980 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_88050 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_88070 Neighboring gene Sharpr-MPRA regulatory region 2872 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_88113 Neighboring gene 5'-nucleotidase domain containing 1 Neighboring gene MPRA-validated peak6050 silencer Neighboring gene collagen type X alpha 1 chain Neighboring gene NIP7 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24981 Neighboring gene TSPY like 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. FRK suppresses human glioma growth by inhibiting ITGB1/FAK signaling. Wang J, et al. Biochem Biophys Res Commun, 2019 Oct 1. PMID 31395336
  2. FRK plays an oncogenic role in non-small cell lung cancer by enhancing the stemness phenotype via induction of metabolic reprogramming. Zhang L, et al. Int J Cancer, 2020 Jan 1. PMID 31251822
  3. Targetable fusions of the FRK tyrosine kinase in ALK-negative anaplastic large cell lymphoma. Hu G, et al. Leukemia, 2018 Feb. PMID 29026208, Free PMC Article
  4. Repression of Fyn-related kinase in breast cancer cells is associated with promoter site-specific CpG methylation. Bagu ET, et al. Oncotarget, 2017 Feb 14. PMID 28077797, Free PMC Article
  5. Fyn-related kinase expression predicts favorable prognosis in patients with cervical cancer and suppresses malignant progression by regulating migration and invasion. Zhang X, et al. Biomed Pharmacother, 2016 Dec. PMID 27665472

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hemifacial microsomia is linked to a rare homozygous variant V162I in FRK and validated in zebrafish.
    Title: Hemifacial microsomia is linked to a rare homozygous variant V162I in FRK and validated in zebrafish.
  2. FRK inhibits glioblastoma progression via phosphorylating YAP and inducing its ubiquitylation and degradation by Siah1.
    Title: FRK inhibits glioblastoma progression via phosphorylating YAP and inducing its ubiquitylation and degradation by Siah1.
  3. GATA6 activated long non-coding RNA PCAT1 maintains stemness of non-small cell lung cancer by mediating FRK.
    Title: GATA6 activated long non-coding RNA PCAT1 maintains stemness of non-small cell lung cancer by mediating FRK.
  4. Recurrent chromosomal rearrangements of ROS1, FRK and IL6 activating JAK/STAT pathway in inflammatory hepatocellular adenomas.
    Title: Recurrent chromosomal rearrangements of ROS1, FRK and IL6 activating JAK/STAT pathway in inflammatory hepatocellular adenomas.
  5. Down-Regulation of miR-2053 Inhibits the Development and Progression of Esophageal Carcinoma by Targeting Fyn-Related Kinase (FRK).
    Title: Down-Regulation of miR-2053 Inhibits the Development and Progression of Esophageal Carcinoma by Targeting Fyn-Related Kinase (FRK).
  6. Furry protein suppresses nuclear localization of yes-associated protein (YAP) by activating NDR kinase and binding to YAP.
    Title: Furry protein suppresses nuclear localization of yes-associated protein (YAP) by activating NDR kinase and binding to YAP.
  7. These results indicate that FRK inhibits human glioma growth via regulating ITGB1/FAK signaling.
    Title: FRK suppresses human glioma growth by inhibiting ITGB1/FAK signaling.
  8. Activated BRK-mediated degradation of SMAD4 is associated with the repression of tumor suppressor gene FRK.
    Title: BRK phosphorylates SMAD4 for proteasomal degradation and inhibits tumor suppressor FRK to control SNAIL, SLUG, and metastatic potential.
  9. TRIM44 promotes cell proliferation by regulating FRK.
    Title: TRIM44 promotes cell proliferation and migration by inhibiting FRK in renal cell carcinoma.
  10. FRK plays an oncogenic role in lung cancer cells via a novel regulation mechanism of enhancing the stemness of H1299 cells by inducing metabolism reprogramming, which finally promotes epithelial-mesenchymal transition and metastasis
    Title: FRK plays an oncogenic role in non-small cell lung cancer by enhancing the stemness phenotype via induction of metabolic reprogramming.
Submit: New GeneRIF Correction See all GeneRIFs (27)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Biological, clinical and population relevance of 95 loci for blood lipids.
EBI GWAS Catalog
Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration.
EBI GWAS Catalog
Discovery and refinement of loci associated with lipid levels.
EBI GWAS Catalog
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine kinase activity EXP
Inferred from Experiment
more info
 PubMed 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in azurophil granule lumen TAS
Traceable Author Statement
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus TAS
Traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in specific granule lumen TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
tyrosine-protein kinase FRK
Names
PTK5 protein tyrosine kinase 5
fyn-related kinase
nuclear tyrosine protein kinase RAK
protein-tyrosine kinase 5
NP_002022.1
XP_005266937.1
XP_005266938.1
XP_011533956.1
XP_011533957.1
XP_011533958.1
XP_016866134.1
XP_047274510.1
XP_047274511.1
XP_054210960.1
XP_054210961.1
XP_054210962.1
XP_054210963.1
XP_054210964.1
XP_054210965.1
XP_054210966.1
XP_054210967.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002031.3 → NP_002022.1  tyrosine-protein kinase FRK

    See identical proteins and their annotated locations for NP_002022.1

    Status: REVIEWED

    Source sequence(s)
    AL021451, AL121963, AL357141
    Consensus CDS
    CCDS5103.1
    UniProtKB/Swiss-Prot
    B4DY49, P42685, Q13128, Q9NTR5
    UniProtKB/TrEMBL
    B2R8C2
    Related
    ENSP00000476145.1, ENST00000606080.2
    Conserved Domains (3) summary
    cd10369
    Location:112 → 207
    SH2_Src_Frk; Src homology 2 (SH2) domain found in the Fyn-related kinase (Frk)
    cd11845
    Location:47 → 104
    SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases
    cd05068
    Location:225 → 494
    PTKc_Frk_like; Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    115931149..116100725 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011535656.3 → XP_011533958.1  tyrosine-protein kinase FRK isoform X2

    Conserved Domains (3) summary
    cd05068
    Location:112 → 381
    PTKc_Frk_like; Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases
    pfam07714
    Location:121 → 374
    Pkinase_Tyr; Protein tyrosine kinase
    cl15255
    Location:3 → 94
    SH2; Src homology 2 (SH2) domain

  2. XM_011535655.3 → XP_011533957.1  tyrosine-protein kinase FRK isoform X1

    See identical proteins and their annotated locations for XP_011533957.1

    UniProtKB/Swiss-Prot
    B4DY49, P42685, Q13128, Q9NTR5
    UniProtKB/TrEMBL
    B2R8C2
    Conserved Domains (3) summary
    cd10369
    Location:112 → 207
    SH2_Src_Frk; Src homology 2 (SH2) domain found in the Fyn-related kinase (Frk)
    cd11845
    Location:47 → 104
    SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases
    cd05068
    Location:225 → 494
    PTKc_Frk_like; Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases

  3. XM_011535654.3 → XP_011533956.1  tyrosine-protein kinase FRK isoform X1

    See identical proteins and their annotated locations for XP_011533956.1

    UniProtKB/Swiss-Prot
    B4DY49, P42685, Q13128, Q9NTR5
    UniProtKB/TrEMBL
    B2R8C2
    Conserved Domains (3) summary
    cd10369
    Location:112 → 207
    SH2_Src_Frk; Src homology 2 (SH2) domain found in the Fyn-related kinase (Frk)
    cd11845
    Location:47 → 104
    SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases
    cd05068
    Location:225 → 494
    PTKc_Frk_like; Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases

  4. XM_047418554.1 → XP_047274510.1  tyrosine-protein kinase FRK isoform X1

    UniProtKB/Swiss-Prot
    B4DY49, P42685, Q13128, Q9NTR5

  5. XM_047418555.1 → XP_047274511.1  tyrosine-protein kinase FRK isoform X1

    UniProtKB/Swiss-Prot
    B4DY49, P42685, Q13128, Q9NTR5

  6. XM_017010645.2 → XP_016866134.1  tyrosine-protein kinase FRK isoform X1

    UniProtKB/Swiss-Prot
    B4DY49, P42685, Q13128, Q9NTR5
    UniProtKB/TrEMBL
    B2R8C2
    Conserved Domains (3) summary
    cd10369
    Location:112 → 207
    SH2_Src_Frk; Src homology 2 (SH2) domain found in the Fyn-related kinase (Frk)
    cd11845
    Location:47 → 104
    SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases
    cd05068
    Location:225 → 494
    PTKc_Frk_like; Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases

  7. XM_005266880.5 → XP_005266937.1  tyrosine-protein kinase FRK isoform X1

    See identical proteins and their annotated locations for XP_005266937.1

    UniProtKB/Swiss-Prot
    B4DY49, P42685, Q13128, Q9NTR5
    UniProtKB/TrEMBL
    B2R8C2
    Conserved Domains (3) summary
    cd10369
    Location:112 → 207
    SH2_Src_Frk; Src homology 2 (SH2) domain found in the Fyn-related kinase (Frk)
    cd11845
    Location:47 → 104
    SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases
    cd05068
    Location:225 → 494
    PTKc_Frk_like; Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases

  8. XM_005266881.3 → XP_005266938.1  tyrosine-protein kinase FRK isoform X1

    See identical proteins and their annotated locations for XP_005266938.1

    UniProtKB/Swiss-Prot
    B4DY49, P42685, Q13128, Q9NTR5
    UniProtKB/TrEMBL
    B2R8C2
    Conserved Domains (3) summary
    cd10369
    Location:112 → 207
    SH2_Src_Frk; Src homology 2 (SH2) domain found in the Fyn-related kinase (Frk)
    cd11845
    Location:47 → 104
    SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases
    cd05068
    Location:225 → 494
    PTKc_Frk_like; Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    117114676..117284719 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054354992.1 → XP_054210967.1  tyrosine-protein kinase FRK isoform X2

  2. XM_054354990.1 → XP_054210965.1  tyrosine-protein kinase FRK isoform X1

    UniProtKB/Swiss-Prot
    B4DY49, P42685, Q13128, Q9NTR5

  3. XM_054354991.1 → XP_054210966.1  tyrosine-protein kinase FRK isoform X1

    UniProtKB/Swiss-Prot
    B4DY49, P42685, Q13128, Q9NTR5

  4. XM_054354986.1 → XP_054210961.1  tyrosine-protein kinase FRK isoform X1

    UniProtKB/Swiss-Prot
    B4DY49, P42685, Q13128, Q9NTR5

  5. XM_054354989.1 → XP_054210964.1  tyrosine-protein kinase FRK isoform X1

    UniProtKB/Swiss-Prot
    B4DY49, P42685, Q13128, Q9NTR5

  6. XM_054354987.1 → XP_054210962.1  tyrosine-protein kinase FRK isoform X1

    UniProtKB/Swiss-Prot
    B4DY49, P42685, Q13128, Q9NTR5

  7. XM_054354985.1 → XP_054210960.1  tyrosine-protein kinase FRK isoform X1

    UniProtKB/Swiss-Prot
    B4DY49, P42685, Q13128, Q9NTR5

  8. XM_054354988.1 → XP_054210963.1  tyrosine-protein kinase FRK isoform X1

    UniProtKB/Swiss-Prot
    B4DY49, P42685, Q13128, Q9NTR5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P42685.1 GenPept UniProtKB/Swiss-Prot:P42685

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